Collection
60 years of metformin use: a glance at the past and a look to the future
- Submission status
- Closed
To mark the 60th anniversary of the first clinical use of metformin for diabetes, Diabetologia has commissioned a series of articles on the many evolving (and controversial) aspects of metformin use. To begin, a historical overview is provided by Clifford Bailey, followed by an outline of the mechanisms of action by Rena et al. Sanchez-Rangel and Inzucchi go on to present data for the efficacy and safety of metformin in type 2 diabetes, for which it is the first-line therapy. In contrast, Livingstone and colleagues discuss its use in type 1 diabetes and Aroda et al present findings for its potential use for diabetes prevention. Griffin et al investigate the association between metformin and cardiovascular disease risk by conducting a meta-analysis, whilst Sam and Ehrmann and Lindsay and Loeken discuss its use in polycystic ovary syndrome and pregnancy, respectively. Metformin therapy in the ageing population is reviewed by Valencia et al, and Michael Pollak confers the non-glycaemic effects of metformin, suggesting a role for the human microbiota/gut metabolome and the immune system. Another emerging area of interest, the impact of metformin on cancer incidence and mortality, is covered by Heckman-Stoddard et al. Finally, to address the heterogeneity in response to metformin therapy, Jose Florez advises how a personalised approach may be achieved using genetic studies. In summary, this review series demonstrates how metformin shows promise in many conditions, but how long can this drug remain at the top spot?
Articles (13 in this collection)
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The pharmacogenetics of metformin
Authors
- Jose C. Florez
- Content type: Review
- Published: 03 August 2017
- Pages: 1648 - 1655
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60 years of metformin use: a glance at the past and a look to the future
Authors
- Sally M. Marshall
- Content type: Editorial
- Published: 03 August 2017
- Pages: 1561 - 1565
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Metformin: historical overview
Authors
- Clifford J. Bailey
- Content type: Commentary
- Published: 03 August 2017
- Pages: 1566 - 1576
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The mechanisms of action of metformin
Authors
- Graham Rena
- D. Grahame Hardie
- Ewan R. Pearson
- Content type: Review
- Open Access
- Published: 03 August 2017
- Pages: 1577 - 1585
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Repurposing metformin for the prevention of cancer and cancer recurrence
Authors (first, second and last of 4)
- Brandy M. Heckman-Stoddard
- Andrea DeCensi
- Leslie G. Ford
- Content type: Review
- Published: 03 August 2017
- Pages: 1639 - 1647
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A new perspective on metformin therapy in type 1 diabetes
Authors (first, second and last of 4)
- Rachel Livingstone
- James G. Boyle
- on behalf of The REMOVAL Study Team
- Content type: Review
- Open Access
- Published: 02 August 2017
- Pages: 1594 - 1600
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The effects of metformin on gut microbiota and the immune system as research frontiers
Authors
- Michael Pollak
- Content type: Review
- Published: 02 August 2017
- Pages: 1662 - 1667
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Metformin for diabetes prevention: insights gained from the Diabetes Prevention Program/Diabetes Prevention Program Outcomes Study
Authors (first, second and last of 14)
- Vanita R. Aroda
- William C. Knowler
- for the Diabetes Prevention Program Research Group
- Content type: Review
- Published: 02 August 2017
- Pages: 1601 - 1611
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Metformin use in pregnancy: promises and uncertainties
Authors
- Robert S. Lindsay
- Mary R. Loeken
- Content type: Review
- Open Access
- Published: 02 August 2017
- Pages: 1612 - 1619
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Metformin and ageing: improving ageing outcomes beyond glycaemic control
Authors (first, second and last of 4)
- Willy Marcos Valencia
- Ana Palacio
- Hermes Florez
- Content type: Review
- Published: 02 August 2017
- Pages: 1630 - 1638
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Impact of metformin on cardiovascular disease: a meta-analysis of randomised trials among people with type 2 diabetes
Authors
- Simon J. Griffin
- James K. Leaver
- Greg J. Irving
- Content type: Review
- Open Access
- Published: 02 August 2017
- Pages: 1620 - 1629
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Metformin: clinical use in type 2 diabetes
Authors
- Elizabeth Sanchez-Rangel
- Silvio E. Inzucchi
- Content type: Review
- Published: 02 August 2017
- Pages: 1586 - 1593