Generalizability of polygenic prediction models: how is the R2 defined on test data?
Authors (first, second and last of 5)
Collection
Generalisation of Genomic Findings and Applications of Polygenic Risk Scores
A multitude of genetic markers have been produced by large genomic datasets and unprecedented computational methods. Polygenic Risk Scores (PRS) encompass many markers to ascertain an individual's combined score for a particular trait. Numerous studies demonstrate that PRS could be a promising tool to estimate genetic risk for a range of common diseases of public health significance.
Articles (9 in this collection)
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Identification of diagnostic model in heart failure with myocardial fibrosis and conduction block by integrated gene co-expression network analysis
Authors (first, second and last of 6)
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MPZL2—a common autosomal recessive deafness gene related to moderate sensorineural hearing loss in the Chinese population
Authors (first, second and last of 10)
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Novel pathogenic variant in MED12 causing non-syndromic dilated cardiomyopathy
Authors (first, second and last of 5)
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Polygenic risk for triglyceride levels in the presence of a high impact rare variant
Authors (first, second and last of 10)
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The association between basal metabolic rate and osteoarthritis: a Mendelian randomization study
Authors (first, second and last of 10)
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Assessing the performance of European-derived cardiometabolic polygenic risk scores in South-Asians and their interplay with family history
Authors (first, second and last of 6)
