Novel Biomarkers and Cellular Mechanisms in Breast Cancer: Insights from In Vitro and In Vivo Single-Cell Studies

Breast cancer research has significantly advanced in understanding cellular mechanisms and identifying crucial biomarkers for diagnosis, prognosis, and treatment. Further exploration is necessary to delve into the complexities of breast cancer progression, metastasis, and treatment responses. This collection will showcase pioneering research utilizing single-cell transcriptomics to reveal novel biomarkers and elucidate cellular mechanisms underpinning breast cancer progression and treatment responses. The studies will encompass both in vitro and in vivo research, focusing on metabolic and immunological heterogeneity within the tumour microenvironment. Additionally, it seeks to explore how these insights can be translated into potential therapeutic targets and predictive markers for the efficacy of immunotherapy and chemotherapy, thereby bridging the gap between laboratory findings and clinical strategies. The collection scope includes, but is not limited to, the following topics: •     Biomarker identification and validation •     Tumour heterogeneity in breast cancer •     Signalling pathways and molecular mechanisms •     In vitro and in vivo models for breast cancer research •     Single-cell analysis and its implications •     Therapeutic targets and personalized medicine.