Collection
Advanced Non-viral Delivery Systems in Tissue Engineering
- Submission status
- Open
- Open for submission from
- 09 January 2023
- Submission deadline
- Ongoing
Tissue engineering is the process of modulating the biological function of target cells and/or tissues. From this point of view, the use of small molecule drugs, biomacromolecules, and stem cells as external mediator effectors is particularly promising, as their chemical composition and bioactivity can be well-customized prior to use to fulfill both the modulation function and safety profile, and thus have greatly promoted the development of tissue engineering. However, a common dilemma of these external mediators is that direct administration of these highly bioactive small molecules, biomacromolecules, and stem cells either systemically or topically usually results in a relatively low effect in the target tissues due to the presence of multiple systemic and intracellular biological barriers. In this regard, the use of delivery systems is dispensable to effectively overcome the various biological barriers to improve the bioavailability and therapeutic efficiency of small molecule drugs, biomacromolecules, and stem cells.
Viral delivery systems, while more efficient, also pose potential safety risks. In contrast, non-viral delivery systems have their own advantageous properties, such as ease of synthesis, high flexibility in chemical composition, and biological functions, although different design principles are required for each of small molecule drugs, biomacromolecules, and stem cells. Advances in materials science, chemistry, biotechnology, and even engineering have greatly promoted the development of non-viral delivery systems. In conjunction with the increasing understanding of histogenesis and pathogenesis, exciting and encouraging results have been achieved in both research and clinical applications of non-viral delivery systems. Meanwhile, new challenges have emerged in the translation of the non-viral delivery systems from the laboratory to the clinic. This collection is intended to present both the exciting new results in experiments and a summary of recent progress in the development of non-viral delivery systems for small molecules, biomacromolecules, and stem cells for tissue engineering. It is anticipated that new trends can be derived from the research conducted to illuminate the potential opportunities for further development of clinically viable non-viral delivery systems to accelerate translation.
Potential topics include, but are not limited to:
1) Lipids and lipid nanoparticles for delivery of small molecule drug, DNA or RNA
2) Polymers for delivery of small molecule drug, DNA or RNA
3) Natural or synthetic polymers for stem cell encapsulation
4) Strategies for the preparation of biomaterials
5) Formulation of delivery systems for small molecule drug, DNA or RNA
Editors
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Dezhong Zhou
School of Chemical Engineering and Technology, Xi’an Jiaotong University, Xi’an 710049, Shaanxi, PR China
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Wenxin Wang
Charles Institute of Dermatology, School of Medicine and Medical Science, University College Dublin, Dublin 4, Ireland
Articles (47 in this collection)
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A multifunctional composite scaffold responds to microenvironment and guides osteogenesis for the repair of infected bone defects
Authors (first, second and last of 7)
- Jiajia Sun
- Haidi Zhu
- Huilin Yang
- Content type: Research
- Open Access
- Published: 19 September 2024
- Article: 577
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Brain-on-a-chip: an emerging platform for studying the nanotechnology-biology interface for neurodegenerative disorders
Authors
- Raquel O. Rodrigues
- Su-Ryon Shin
- Manuel Bañobre-López
- Content type: Review
- Open Access
- Published: 18 September 2024
- Article: 573
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Role of size, surface charge, and PEGylated lipids of lipid nanoparticles (LNPs) on intramuscular delivery of mRNA
Authors (first, second and last of 10)
- Weiwen Kong
- Yuning Wei
- Jianping Qi
- Content type: Research
- Open Access
- Published: 11 September 2024
- Article: 553
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Hyaluronic acid-coated polypeptide nanogel enhances specific distribution and therapy of tacrolimus in rheumatoid arthritis
Authors (first, second and last of 9)
- Yuhuan Li
- Xin Wang
- Modi Yang
- Content type: Research
- Open Access
- Published: 06 September 2024
- Article: 547
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Stem cell recruitment polypeptide hydrogel microcarriers with exosome delivery for osteoarthritis treatment
Authors (first, second and last of 5)
- Lei Yang
- Wenzhao Li
- Luoran Shang
- Content type: Research
- Open Access
- Published: 27 August 2024
- Article: 512
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Alkaline phosphatase-activated prodrug system based on a bifunctional CuO NP tandem nanoenzyme for on-demand bacterial inactivation and wound disinfection
Authors (first, second and last of 9)
- Quan-Quan Zhuang
- Zhi-Shan Zhang
- Wei Chen
- Content type: Research
- Open Access
- Published: 13 August 2024
- Article: 485
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A multifunctional injectable, self-healing, and adhesive hydrogel-based wound dressing stimulated diabetic wound healing with combined reactive oxygen species scavenging, hyperglycemia reducing, and bacteria-killing abilities
Authors (first, second and last of 14)
- Rong Chen
- Pinkai Wang
- Hao Cheng
- Content type: Research
- Open Access
- Published: 27 July 2024
- Article: 444
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Adipose-derived stem cell exosomes loaded with icariin alleviates rheumatoid arthritis by modulating macrophage polarization in rats
Authors (first, second and last of 11)
- Qiqi Yan
- Haixia Liu
- Zhiguo Zhang
- Content type: Research
- Open Access
- Published: 18 July 2024
- Article: 423
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Reactive oxygen species/glutathione dual sensitive nanoparticles with encapsulation of miR155 and curcumin for synergized cancer immunotherapy
Authors (first, second and last of 8)
- Kangkang Li
- Juan Wang
- Xuehong Chen
- Content type: Research
- Open Access
- Published: 08 July 2024
- Article: 400
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Targeting delivery of miR-146a via IMTP modified milk exosomes exerted cardioprotective effects by inhibiting NF-κB signaling pathway after myocardial ischemia-reperfusion injury
Authors (first, second and last of 10)
- Wan-ting Meng
- Jing Zhu
- Guang Ji
- Content type: Research
- Open Access
- Published: 01 July 2024
- Article: 382
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Cartilage progenitor cells derived extracellular vesicles-based cell-free strategy for osteoarthritis treatment by efficient inflammation inhibition and extracellular matrix homeostasis restoration
Authors (first, second and last of 8)
- Kai Feng
- Feng Wang
- Qinglin Kang
- Content type: Research
- Open Access
- Published: 19 June 2024
- Article: 345
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Exosomes target HBV-host interactions to remodel the hepatic immune microenvironment
Authors
- Xiaojing Wu
- Junqi Niu
- Ying Shi
- Content type: Review
- Open Access
- Published: 05 June 2024
- Article: 315
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Chondroitin sulfate-modified tragacanth gum–gelatin composite nanocapsules loaded with curcumin nanocrystals for the treatment of arthritis
Authors (first, second and last of 12)
- Junpeng Sun
- Jiaqun Du
- Chao Wu
- Content type: Research
- Open Access
- Published: 20 May 2024
- Article: 270
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Microneedles loaded with cerium-manganese oxide nanoparticles for targeting macrophages in the treatment of rheumatoid arthritis
Authors (first, second and last of 12)
- Tian Xia
- Yuting Zhu
- Zhen Wang
- Content type: Research
- Open Access
- Published: 11 March 2024
- Article: 103
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EphA2-specific microvesicles derived from tumor cells facilitate the targeted delivery of chemotherapeutic drugs for osteosarcoma therapy
Authors (first, second and last of 6)
- Zhenggang Wang
- Zhiyi He
- Wentao Zhu
- Content type: Research
- Open Access
- Published: 03 March 2024
- Article: 89
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Macrophage membrane (MMs) camouflaged near-infrared (NIR) responsive bone defect area targeting nanocarrier delivery system (BTNDS) for rapid repair: promoting osteogenesis via phototherapy and modulating immunity
Authors (first, second and last of 10)
- Peng Xue
- Zhiyong Chang
- Bin Du
- Content type: Research
- Open Access
- Published: 01 March 2024
- Article: 87
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Recent progress of non-linear topological structure polymers: synthesis, and gene delivery
Authors (first, second and last of 11)
- Chenfei Wang
- Wei He
- Ming Li
- Content type: Review
- Open Access
- Published: 27 January 2024
- Article: 40
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Bimodal DNA self-origami material with nucleic acid function enhancement
Authors (first, second and last of 12)
- Songlin He
- Haotian Deng
- Quanyi Guo
- Content type: Research
- Open Access
- Published: 26 January 2024
- Article: 39
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Antifungal activity of copper oxide nanoparticles derived from Zizyphus spina leaf extract against Fusarium root rot disease in tomato plants
Authors (first, second and last of 6)
- Sozan E. El-Abeid
- Mohamed A. Mosa
- Maha S. A. Haridy
- Content type: Research
- Open Access
- Published: 12 January 2024
- Article: 28
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Recent trends in preparation and biomedical applications of iron oxide nanoparticles
Authors (first, second and last of 13)
- Yu Qing Meng
- Ya Nan Shi
- Ji Gang Wang
- Content type: Review
- Open Access
- Published: 08 January 2024
- Article: 24
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Encapsulation and assessment of therapeutic cargo in engineered exosomes: a systematic review
Authors (first, second and last of 6)
- Zhen Chen
- Min Xiong
- Lin Zhang
- Content type: Review
- Open Access
- Published: 03 January 2024
- Article: 18
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Exosome-based engineering strategies for the diagnosis and treatment of oral and maxillofacial diseases
Authors (first, second and last of 11)
- Jianing Ren
- Xuan Jing
- Xiuping Wu
- Content type: Review
- Open Access
- Published: 21 December 2023
- Article: 501
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Potential therapeutic effects of milk-derived exosomes on intestinal diseases
Authors (first, second and last of 9)
- Zhifu Cui
- Felix Kwame Amevor
- Lingbin Liu
- Content type: Review
- Open Access
- Published: 20 December 2023
- Article: 496
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Ultrasound-targeted microbubble destruction promotes PDGF-primed bone mesenchymal stem cell transplantation for myocardial protection in acute Myocardial Infarction in rats
Authors (first, second and last of 14)
- Zhenxing Sun
- Yu Cai
- Xiangming Zhu
- Content type: Research
- Open Access
- Published: 15 December 2023
- Article: 481
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Nanogels with covalently bound and releasable trehalose for autophagy stimulation in atherosclerosis
Authors (first, second and last of 8)
- Yuan Zhong
- Ali Maruf
- Wei Wu
- Content type: Research
- Open Access
- Published: 08 December 2023
- Article: 472
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Plant-derived nanovesicles: harnessing nature's power for tissue protection and repair
Authors (first, second and last of 10)
- Xiaohang Chen
- Xiaojie Xing
- Dali Zheng
- Content type: Review
- Open Access
- Published: 24 November 2023
- Article: 445
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Microvesicles-hydrogel breaks the cycle of cellular senescence by improving mitochondrial function to treat osteoarthritis
Authors (first, second and last of 11)
- Senrui Liu
- Shengwen Cheng
- Wei Huang
- Content type: Research
- Open Access
- Published: 15 November 2023
- Article: 429
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Magnetic vagus nerve stimulation alleviates myocardial ischemia-reperfusion injury by the inhibition of pyroptosis through the M2AChR/OGDHL/ROS axis in rats
Authors (first, second and last of 11)
- Yao Lu
- Kaiyan Chen
- Fengxiang Zhang
- Content type: Research
- Open Access
- Published: 14 November 2023
- Article: 421
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Superior TRAIL gene expression and cancer cell apoptosis mediated by highly branched-linear poly(β-amino ester)s
Authors (first, second and last of 9)
- Yitong Zhao
- Tao Bo
- Si Zhang
- Content type: Research
- Open Access
- Published: 28 October 2023
- Article: 394
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Engineering siRNA therapeutics: challenges and strategies
Authors (first, second and last of 6)
- Syed Saqib Ali Zaidi
- Faria Fatima
- Shuai Liu
- Content type: Review
- Open Access
- Published: 18 October 2023
- Article: 381
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Exploring the translational potential of PLGA nanoparticles for intra-articular rapamycin delivery in osteoarthritis therapy
Authors (first, second and last of 10)
- Jian-Chao Ma
- Tingting Luo
- Zhong-Kai Cui
- Content type: Research
- Open Access
- Published: 04 October 2023
- Article: 361
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Bone-targeting exosome nanoparticles activate Keap1 / Nrf2 / GPX4 signaling pathway to induce ferroptosis in osteosarcoma cells
Authors (first, second and last of 12)
- Wenkai Chen
- Zongguang Li
- Guangrong Ji
- Content type: Research
- Open Access
- Published: 30 September 2023
- Article: 355
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Multifunctional CaCO3@Cur@QTX125@HA nanoparticles for effectively inhibiting growth of colorectal cancer cells
Authors (first, second and last of 10)
- Shengyun Hu
- Kunkun Xia
- Zhiyong Zhang
- Content type: Research
- Open Access
- Published: 29 September 2023
- Article: 353
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Multi-functional conductive hydrogels based on heparin–polydopamine complex reduced graphene oxide for epidermal sensing and chronic wound healing
Authors (first, second and last of 5)
- Yiyong Dou
- Yuwei Zhang
- Hong Zhang
- Content type: Research
- Open Access
- Published: 23 September 2023
- Article: 343
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Designing a microbial fermentation-functionalized alginate microsphere for targeted release of 5-ASA using nano dietary fiber carrier for inflammatory bowel disease treatment
Authors (first, second and last of 14)
- Lei Qiu
- Renbin Shen
- Qiang Yu
- Content type: Research
- Open Access
- Published: 23 September 2023
- Article: 344
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Engineering exosomes derived from subcutaneous fat MSCs specially promote cartilage repair as miR-199a-3p delivery vehicles in Osteoarthritis
Authors (first, second and last of 11)
- Shu Zhao
- Guanghui Xiu
- Jun Xu
- Content type: Research
- Open Access
- Published: 22 September 2023
- Article: 341
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Targeted therapy using engineered extracellular vesicles: principles and strategies for membrane modification
Authors (first, second and last of 4)
- Qisong Liu
- Defeng Li
- Yujie Liang
- Content type: Review
- Open Access
- Published: 16 September 2023
- Article: 334
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Polyurethane-based nanofibrous mat containing porphyrin with photosensitivity and bactericidal properties can promote cutaneous tissue healing in rats
Authors (first, second and last of 11)
- Solmaz Saghebasl
- Hassan Amini
- Reza Rahbarghazi
- Content type: Research
- Open Access
- Published: 04 September 2023
- Article: 313
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A swift expanding trend of extracellular vesicles in spinal cord injury research: a bibliometric analysis
Authors (first, second and last of 8)
- Fan Zhiguo
- Wu Ji
- Xiao Zhai
- Content type: Review
- Open Access
- Published: 23 August 2023
- Article: 289
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The current status of stimuli-responsive nanotechnologies on orthopedic titanium implant surfaces
Authors (first, second and last of 7)
- Jingyuan Han
- Qianli Ma
- Jing Wang
- Content type: Review
- Open Access
- Published: 19 August 2023
- Article: 277
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Emerging non-viral vectors for gene delivery
Authors (first, second and last of 9)
- Chenfei Wang
- Chaolan Pan
- Ming Li
- Content type: Review
- Open Access
- Published: 17 August 2023
- Article: 272
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Nano drug delivery systems: a promising approach to scar prevention and treatment
Authors (first, second and last of 6)
- Jia-Ying Ding
- Lu Sun
- Yan-Wei Xiang
- Content type: Review
- Open Access
- Published: 11 August 2023
- Article: 268
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Black phosphorus quantum dots camouflaged with platelet-osteosarcoma hybrid membrane and doxorubicin for combined therapy of osteosarcoma
Authors (first, second and last of 8)
- Yanlong Xu
- Longhai Du
- Zuochong Yu
- Content type: Research
- Open Access
- Published: 28 July 2023
- Article: 243
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Biomimetic hypoxia-triggered RNAi nanomedicine for synergistically mediating chemo/radiotherapy of glioblastoma
Authors (first, second and last of 12)
- Zhen Wang
- Xiang-long Tang
- Hong-yi Liu
- Content type: Methodology
- Open Access
- Published: 05 July 2023
- Article: 210
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Yunnan Baiyao-loaded multifunctional microneedle patches for rapid hemostasis and cutaneous wound healing
Authors (first, second and last of 5)
- Jie Yang
- Xiaocheng Wang
- Yuanjin Zhao
- Content type: Research
- Open Access
- Published: 06 June 2023
- Article: 178
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Genetically engineered CXCR4-modified exosomes for delivery of miR-126 mimics to macrophages alleviate periodontitis
Authors (first, second and last of 9)
- Haotian Luo
- Danying Chen
- Chen Zhou
- Content type: Research
- Open Access
- Published: 30 March 2023
- Article: 116