Collection
Pharmacogenomics Beyond Single Common Genetic Variants
- Submission status
- Closed
In this Collection, we invite original research articles, case reports, meta-analyses, and reviews that focus on associations between genetic variability with drug metabolism, response or toxicity. We particularly welcome reports that identify combinatorial variant effects in cis or trans, epigenetic variations, regulation of gene expression by non-coding RNAs as well as polygenic models for drug response and safety predictions. Pharmacogenetic and -genomic studies of both the germline and somatic genome will be considered. The Collection is furthermore open to implementation studies that demonstrate feasibility or outcomes of point-of-care genetic profiling.
Articles (8 in this collection)
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Pharmacogenetics in Italy: current landscape and future prospects
Authors (first, second and last of 13)
- Matteo Floris
- Antonino Moschella
- Monica Miozzo
- Content type: Perspective
- Open Access
- Published: 10 July 2024
- Article: 78
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Association of lipid-lowering drugs with risk of sarcopenia: a drug target mendelian randomization study and meta-analysis
Authors (first, second and last of 7)
- Jiaxin Li
- Chenyang Zang
- Luo Zhou
- Content type: Research
- Open Access
- Published: 03 July 2024
- Article: 76
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Trace amine associated receptor 1: predicted effects of single nucleotide variants on structure-function in geographically diverse populations
Authors (first, second and last of 6)
- Britto Shajan
- Shashikanth Marri
- Pramod C. Nair
- Content type: Research
- Open Access
- Published: 11 June 2024
- Article: 61
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Prioritization of therapeutic targets for cancers using integrative multi-omics analysis
Authors (first, second and last of 11)
- Xin Jin
- Yunyun Mei
- Lu Wang
- Content type: Research
- Open Access
- Published: 24 April 2024
- Article: 42
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Meta-analysis of the global distribution of clinically relevant CYP2C8 alleles and their inferred functional consequences
Authors (first, second and last of 6)
- Mahamadou D. Camara
- Yitian Zhou
- Volker M. Lauschke
- Content type: Research
- Open Access
- Published: 22 April 2024
- Article: 40
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Large-scale next generation sequencing based analysis of SLCO1B1 pharmacogenetics variants in the Saudi population
Authors (first, second and last of 6)
- Ewa Goljan
- Mohammed Abouelhoda
- Dorota Monies
- Content type: Research
- Open Access
- Published: 25 March 2024
- Article: 30
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The burden of rare variants in DPYS gene is a novel predictor of the risk of developing severe fluoropyrimidine-related toxicity
Authors (first, second and last of 10)
- Elena De Mattia
- Jerry Polesel
- Erika Cecchin
- Content type: Research
- Open Access
- Published: 09 November 2023
- Article: 99