We are pleased to present this special issue on Health Behavior in the Information Age. Health behavior is a primary contributor to health outcomes at all levels (i.e., primary, secondary, tertiary, quaternary) of care. It has been estimated that 40% of the determinants of health are due to our behaviors, with the remaining determinants being related to genetics (30%), social circumstances (15%), environmental exposures (5%), and access to quality medical care (10%) [1]. As such, better understanding of health behaviors and methods for measuring and/or influencing them hold great potential for enhancing human health and well-being.