This special issue of Tropical Medicine and Health has been produced and published to record and celebrate the successes of PacELF - the Pacific Programme for the Elimination of Lymphatic Filariasis. PacELF was designed as a regional programme driven by the 22 island countries and territories in the Pacific for the sole purpose of eliminating lymphatic filariasis (LF). These countries have a wide range of transmission intensity and mosquito vectors. The main strategy for achieving this goal is annual mass drug administration (MDA) using diethylcarbamazine (DEC) with albendazole to stop transmission, together with clinical management of infections to minimize progression of pathology in individuals already infected.