Skip to main content

Histopathological Image Classification Using Deep Neural Networks with Fine-Tuning

  • Conference paper
  • First Online:
Data Engineering and Intelligent Computing

Part of the book series: Advances in Intelligent Systems and Computing ((AISC,volume 1407))

Abstract

The role of deep learning is predominant in classifying medical images. Histopathological image classification involves classifying tumor and cancer tissue subtypes, but it has many challenges like complexity of image, labeled data availability. Overcoming these challenges and accurately classifying the images require better approach than traditional one. In this work, we use fine-tuning-based deep neural network in classifying the histopathological image into eight different classes. The obtained results are compared with different other CNN and machine learning models. In addition, we trained a model using early stopping function which monitors the validation accuracy during training and prevents overfit, which makes the model work trained efficiently. This approach is tested on colorectal cancer histology image dataset which contains 5000 labeled images belonging to eight different classes. In our result, fine-tuning with early stopping performed better than other methods with accuracy of 91.2%.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. https://www.cnbc.com/2018/02/22/medical-errors-third-leading-cause-of-death-in-america.html

  2. Key Statistics for Colorectal Cancer, https://www.cancer.org/cancer/colon-rectal-cancer/about/key-statistics.html

  3. M. Ganz et al., Automatic segmentation of polyps in colonoscopic narrow-band imaging data. IEEE Trans. Biomed. Eng. 59(8), 2144–2151(2012). (440,000 death)

    Google Scholar 

  4. How Telemedicine Answers Global Pathology Demands, 2018, https://proscia.com/blog/2015/07/14/global-crisis-digitalsolution

  5. https://www.expresshealthcare.in/lab-diagnostics/illegal-path-labs-indias-open-secret/413141/

  6. H. Mittal et al., Classification of Histopathological Images Through Bag-of-Visual-Words and Gravitational Search Algorithm, LNSCPS (Springer, 2019), p. 231–241.

    Google Scholar 

  7. S. Pang et al., A novel fused convolutional neural network for biomedical image classification. Med. Biol. Eng. Comput. 57(1), 107–121 (2018)

    Article  Google Scholar 

  8. Y. Zhang et al., Breast cancer diagnosis from biopsy images with highly reliable random subspace classifier ensembles. Springer MVA 24, 1405–1420 (2013)

    Google Scholar 

  9. H. Asri et al., Using machine learning algorithms for breast cancer risk prediction and diagnosis. Elsevier PCS 83, 1064–1069 (2016)

    Google Scholar 

  10. V. Rachapudi et al., Improved Convolutional Neural Network Based Histopathological Image Classification (Springer E.I. 2020).

    Google Scholar 

  11. Kermany et al., Identifying medical diagnoses and treatable diseases by image-based deep learning. Cell 172, 1122–1131 (2018).

    Google Scholar 

  12. R. Pal et al., Enhanced bag of features using alexnet and improved biogeography-based optimization for histopathological image analysis, in Proceedings of IC3 (IEEE, 2018), p 1–6.

    Google Scholar 

  13. Neural Network Early Stopping, https://chrisalbon.com/deep_learning/keras/neural_network_early_stopping/

  14. Yao et al., On early stopping in gradient descent learning. Constr. Approx. 26(2), 289–315 (2007).

    Google Scholar 

  15. Fine-tuning convolutional neural network on own data using keras tensorflow https://cv-tricks.com/keras/fine-tuning-tensorflow/

  16. J.N. Kather et al., Multi-class texture analysis in colorectal cancer histology. Sci. Rep. 6, 27988 (2016)

    Article  Google Scholar 

  17. Dropout Neural Network Layer In Keras Explained https://towardsdatascience.com/machine-learning-part-20-dropout-keras-layers-explained-8c9f6dc4c9ab

  18. Further going on CNN, https://classroom.udacity.com/courses/ud187/lessons/1771027d-8685-496f-8891-d7786efb71e1/concepts/db0b93a6-402d-4f13-8869-cf5fc1fe89ad

  19. J.D.J. Deng et al., ImageNet: a large-scale hierarchical image database, in Proceedings of IEEE ICCVPR, 2009, p. 2–9.

    Google Scholar 

  20. Transfer learning, https://classroom.udacity.com/courses/ud187/lessons/a915f824-ce4a-4f5e-9897-a78ccbff313d/concepts/7fd8f8d5-979a-44ac-8ead-6c19a359f767

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to A. S. Vidyun .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Vidyun, A.S., Srinivasa Rao, B., Harikiran, J. (2021). Histopathological Image Classification Using Deep Neural Networks with Fine-Tuning. In: Bhateja, V., Satapathy, S.C., Travieso-González, C.M., Aradhya, V.N.M. (eds) Data Engineering and Intelligent Computing. Advances in Intelligent Systems and Computing, vol 1407. Springer, Singapore. https://doi.org/10.1007/978-981-16-0171-2_17

Download citation

Publish with us

Policies and ethics