Abstract
Using mice, we found that oral administration of Bifidobacterium breve YIT4064 (B. breve) activated the humoral immune system, augmented anti-rotavirus IgA production or anti-influenza virus (IFV) IgG production and protected against rotavirus infection or influenza infection, respectively. Furthermore, when the B. breve was given to infants from an infant home, there was a significant reduction of the frequency of rotavirus shedding in stool samples during the administration of the bacteria. It was also found, again using mice, that oral administration of Lactobacillus casei strain Shirota (LcS) stimulated type 1 helper T (Thl) cells, activated the cellular immune system and inhibited incidence of tumors and IgE production. These results demonstrated that these two strains of lactic acid bacteria modulated the different immune systems each in its own way and prevented against various diseases.
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References
Agerbaek M, Gerdes LU & Richelsen B (1995) Hypocholesterolaemic effect of a new fermented milk product in healthy middle-aged men. Eur. J. Clin. Nutr. 49: 346–352
Araki T, Shinozaki T, Irie Y & Miyazawa Y (1999) Trial of oral administration of Bifidobacterium breve for the prevention of rotavirus infection. J. Jpn. Assoc. Infect. Dis. 73; 305–310
Aso Y, Akaza H, Kotake T, Tsukamoto T, Imai K, Naito S & the BLP Study Group (1995) Preventive effect of Lactobacillus casei preparation on the recurrence of superficial bladder cancer in a double-blind trial. Eur. Urol. 27: 104–109
Duffy LD, Zielezny MA, Riepenhoff-Talty M, Dryja D, Sayahtaheri-Altaie S, Griffiths E, Ruffin D, Barrett H, Rossman J & Ogra PL (1994) Effectiveness of Bifidobacterium bifldum in mediating the clinical course of murine rotavirus diarrhea. Pediatr. Res. 35: 690–695
Fukushima Y, Kawata Y, Hara H, Terada A & Mitsuoka T (1998) Effect of a probiotic formula on intestinal immunoglobulin A production in healthy children. Int. J. Food Microbiol. 42: 39–44
Gilliland SE (1990) Health and nutritional benefits from lactic acid bacteria. FEMS Microbiol. Rev. 87: 175–188
Goldin BR (1998) Health benefits of probiotics. Br. J. Nutr. 80: S203–5207
Kato I, Endo K & Yokokura T (1994) Effects of oral administration of Lactobacillus casei on anti-tumour responses induced by tumour resection in mice. Int.. Immunopharmacol. 16: 29–36
Majamaa H, Isolauri E, Saxelin M & Vesikari T (1995) Lactic acid bacteria in the treatment of acute rotavirus gastroenteritis. Pediatr. Gastroenterol. Nutr. 20: 333–338
Matsuzaki T, Yamazaki R, Hashimoto S, & Yokokura T (1998) The effect of oral feeding of Lactobacillus casei strain Shirota on immunoglobulin E production in mice. J. Dairy Sci. 81: 48–53
Metchnikoff E (1908) The prolongation of life. G.P. Putnam, 4
Mitsuoka T & Kaneuchi C (1977) Ecology of bifidobacteria. Am. J. Clin. Nutr. 30: 1799–1810
Perdigon G, Alvarez S, Rachid M, Aguero G & Gobbato N (1995) Symposium: Probiotic bacteria for humans: clinical systems for evaluation of effectiveness. J. Dairy Sci. 78: 1597–1606
Perdigon G, Valdez JC & Rachid M (1998) Antitumor activity of yogurt: study of possible immune mechanisms. J. Dairy Res. 65: 129–138
Poupard JA, Husain I & Norrits RF (1973) Biology and bifidobacteria. Bacteriol. Rev. 37: 136–165
Pouwels PH, Leer RJ & Boersma JA (1996) The potential of Lactobacillus as a carrier for oral immunization: development and preliminary characterization of vector systems for targeted delivery of antigens. J. Biotechnol. 44: 183–192
Saavedra M, Bauman NA, Oung I, Perman A & Yolken RH (1994) Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhoea and shedding of rotavirus. 344: 1046–1049
Salminen S, Deighton MA, Benno Y. & Gorbach SL (1998) Lactic acid bacteria in health and disease. Lactic acid bacteria. Marcel Dekker, Inc. 211–253
Shida K, Makino K. Morishita A, Takamizawa K, Hachimura S, Ametani A, Sato T, Kumagai Y, Habu S & Kaminogawa S (1998) Lactobacillus casei inhibits antigen-induced IgE secretion though regulation of cytokine production in mutine splenocyte cultures. Int. Arch. Allergy Immunol. I I: 278–287
Takahashi M, Iwata S, Yamazaki N & Fujiwara H (1991) Phagocytosis of the lactic acid bacteria by M cells in the rabbit Peyer’s patches. J. Clin. Electron. Microsopy. 24: 5–6
Trapp CL, Chang CC, Halpern GM, Keen CL & Gershwin ME (1993) The influence of chronic yogurt consumption on populations of young and elderly adults. Int. J. Immunotherapy IX (1): 53–63
Yamazaki S. Kamimura H, Momose H, Kawashima T & Ueda K (1982) Protective effect of Bifidobacterium monoassociation against lethal activity in Escherichia coll. Bifidobacteria Micro-flora. 1: 55–59
Yasui H & Ohwaki M (1991) IgA production and intestinal micro-flora: augmentation of IgA production by Bifidobacterium breve. Jpn. Clin. Microscopy. 24: 426–430
Yasui H, Nagaoka N, Mike A, Hayakawa K & Ohwaki M (1992) Detection of Bifidobacterium strains that induce large quantities of IgA. Microb. Ecol. Health Dis. 5: 155–162
Yasui H, Nagaoka N & Hayakawa K (1994) Augmentation of anti-influenza virus hemagglutinin antibody production by Peyer’s patch cells with Bifidobacterium breve YIT4064. Clin. Diagn. Lab. Immunol. 1: 244–246
Yasui H, Kiyoshima J & Ushijima H (1995) Passive protection against rotavirus-induced diarrhea of mouse pups born to and nursed by dams fed Bifidobacterium breve YIT4064. J. Infect Dis. 172: 403–409
Yasui H, Kiyosima J, Hori T & Shida K (1999) Protection against influenza virus infection of mice fed Bifidobacterium breve YIT4064. Clin. Diagn. Lab. Immunol. 6: 186–192
Yokokura T (1994) Anti-tumor and immuno-stimulating activities of Lactobacillus casei. Jpn. J. Dairy and Food Science. 43: 141150
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© 1999 Springer Science+Business Media Dordrecht
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Yasui, H., Shida, K., Matsuzaki, T., Yokokura, T. (1999). Immunomodulatory function of lactic acid bacteria. In: Konings, W.N., Kuipers, O.P., In ’t Veld, J.H.J.H. (eds) Lactic Acid Bacteria: Genetics, Metabolism and Applications. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-2027-4_24
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DOI: https://doi.org/10.1007/978-94-017-2027-4_24
Publisher Name: Springer, Dordrecht
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