Abstract
The determination of the relation between administered dose and clinical outcome is one of the most important tasks in the development of a new drug. The ultimate goal of human pharmacology is thus to create an understanding of the events occurring from the moment of administration, via adsorption of the drug, distribution in different organs, metabolism and excretion, responses in target organs and biochemical effector systems to the effects of the whole organism and to clinical outcome. Usually this information is obscured by limitations of the present in vivo measurement techniques which in humans is primarily limited to evaluations of plasma pharmacokinetics. The important intermediate steps in the chain of events from administration to clinical outcome have to be deduced from models by analysing plasma pharmacokinetics, combined with extrapolations from animal experiments.
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Långström, B., Bergström, M., Hartvig, P., Valind, S., Watanabe, Y. (1995). Is PET a Tool for Drug Evaluation?. In: Comar, D. (eds) PET for Drug Development and Evaluation. Developments in Nuclear Medicine, vol 26. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0429-6_3
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DOI: https://doi.org/10.1007/978-94-011-0429-6_3
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