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Interaction of Lisuride with dopaminergic receptors

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PET for Drug Development and Evaluation

Part of the book series: Developments in Nuclear Medicine ((DNUM,volume 26))

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Abstract

The dopaminergic system was the first neurotransmission system in which it was possible to image receptors, neurotransmitter and neurotransmitter reuptake systems.

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References

  • Arnett CD, Wolf AP, Shiue CY, Fowler JS, MacGregor RR, Christman DR,Smith MR. Improve delineation of human dopamine receptors using(18F)-N-methylspiroperidol and PET. J Nucl Med 1986;27:1878–1882.

    PubMed  CAS  Google Scholar 

  • Delforge J, Loc’h C, Hantraye P, Stulzaft O, Khalili-Varasteh M, Mazière M, Syrota A, Mazière B. Kinetic analysis of central [76Br]bromolisuridebinding to dopamine D2 receptors studied by PET. J Cereb Blood Flow Metab 1991;11:914–925.

    Article  PubMed  CAS  Google Scholar 

  • Farde L, Ehrin E, Eriksson L, Greitz T, Hall H, Hedstrom CG, Litton JE, Sedvall G. Substituted benzamides as ligands for visualization of dopamine receptor binding in the human brain by positron emission tomography. Proc Natl Acad Sci USA 1985;82:3863–3867.

    Article  PubMed  CAS  Google Scholar 

  • Farde L, Wiesel FA, Stone-Elander S. Halldin C, Nordström A-L, Hall H. Sedvall G. D2 dopamine receptors in neuroleptic-naive schizophrenic patients. Arch Gen Psychiatry 1990;47:213–219.

    Article  PubMed  CAS  Google Scholar 

  • Farde L, Nordström A-L, Wiesel FA, Pauli S, Halldin C, Sedvall G. Positron emission tomographic analysis of Central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine.relation to extrapyramidal side effects. Arch Gen Psychiatry 1992;49:538–544.

    Article  PubMed  CAS  Google Scholar 

  • Fink H, Morgenstern R, Ott T. 2-Bromolisuride, an Ergot derivative, with dopamine antagonistic and serotonin agonistic properties. Pharmacol. Biochem Behavior 1991;38:321–325.

    Article  CAS  Google Scholar 

  • Friedman AM. Huang CC, Kulmala HA, Dinerstein R, Navone J, Brundsen B. Gawlas D, Cooper M. The use of radiobrominated p- bromospiroperidol for gamma-ray imaging of dopamine receptors. Int J Nucl Med Biol 1982;9:57–61.

    Article  PubMed  CAS  Google Scholar 

  • Frost JJ, Smith AC, Kuhar MJ, Dannals RF, Wagner HN. In vivo binding of 3 H-N-melhylspiperone to dopamine and serotonin receptors. Life Sci 1987;40:987-995.

    Article  PubMed  CAS  Google Scholar 

  • Hartley EJ, Seeman P. The effect of varying (3H)spiperone concentration on its binding parameters. Life Sci 1978;23:513.

    Article  PubMed  CAS  Google Scholar 

  • Horowski R. Wachtel H. Direct dopaminergic action of lisuride hydrogenomaleate, an ergot derivative, in mice. Eur J Pharmacol 1976;36:373–383.

    Article  PubMed  CAS  Google Scholar 

  • Loc’h C, Mazière B. NCA synthesis of radiohalogenated denvatives of lisuride. J Label Compound Radiopharm 1989;26: 100–101.

    Article  Google Scholar 

  • Martinot JL, Paillère-Martinot ML, Loc’h C, Peron-Magnan P, Mazoyer B, Lecrubier Y, Hardy P, Beaufils B, Allilaire JF, Maziere B, Slama MF, Syrota A. Central D2 receptor blockade and antipsychotic effects of neuroleptics. Preliminary study with positron emission tomography. Psychiatry and Psychobiology. 1990;5:231-240.

    Google Scholar 

  • Mazière B. Loc’h C, Hantraye P. Guillon R. Duquesnoy N. Soussaline F. Naquet R. Comar D, Maziere M. 76Br-bromospiroperidol: a new tool for quantitative in vivo imaging of neuroleptic receptors. Life Sci 1984;35:1349–1356.

    Article  PubMed  Google Scholar 

  • Mazière B, Loc h C, Stulzaft O, Hantraye P, Ottaviani M, Comar D, Maziere M. [76Br]Bromolisuride: a new tool for quantitative in vivo imaging of D2 dopamine receptors. Eur J Pharmacol 1986;127:239–247.

    Article  PubMed  Google Scholar 

  • Wachtel HW, Kehr W, Sauer G. Central antidopaminergie properties of 2-bromolisuride, an analogue of the ergot dopamine agonist lisuride. Life Sci 1983;33:2583–2597.

    Article  PubMed  CAS  Google Scholar 

  • Wagner HN, Burns HD, Dannals RF, Wong DF, Langstrom B. Duelfer T, Frost JJ, Ravert HT, Links JM, Rosenbloom SB, Lukas SE, Kramer AV. Kuhar MJ. Imaging dopamine receptors in the human brain by positron emission tomography. Science 1983;221: 1264– 1266.

    Article  PubMed  CAS  Google Scholar 

  • Zikan V, Semonsky M. Mutterkorn-alkaloide:31 Mitt.: Ein Betrag zur Herstellung von N-(D-6-Methyl-8-lsoergolenyl)-N´,N´-Diärthylharnstoff. Pharmazie, 1968; 23:147–148.

    CAS  Google Scholar 

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© 1995 Springer Science+Business Media Dordrecht

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Mazière, B., Horowski, R. (1995). Interaction of Lisuride with dopaminergic receptors. In: Comar, D. (eds) PET for Drug Development and Evaluation. Developments in Nuclear Medicine, vol 26. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0429-6_18

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  • DOI: https://doi.org/10.1007/978-94-011-0429-6_18

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4191-1

  • Online ISBN: 978-94-011-0429-6

  • eBook Packages: Springer Book Archive

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