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COX-2 expression and inhibition in human monocytes

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Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors

Abstract

The conversion of arachidonic acid to prostaglandin (PG) H2 is catalysed by PG-endoperoxide synthase (PGHS) which exhibits both cyclooxygenase (COX) and peroxidase activities1. PGH2 is further metabolized by other enzymes to various prostanoids (PGs, prostacyclin and thromboxane A2). Two isozymes of PGHS exist, referred to as PGHS-1 and PGHS-2 or COX-1 and COX-22. COX-1 is a constitutive enzyme present in almost all cell types3, and is the major isoform found in gastrointestinal tissue4. Prostanoid production by COX-1 is involved in physiological functions such as vascular homeostasis, control of kidney function and gastric cytoprotection2. COX-2 is induced in a more restricted, cell-specific fashion by mitogenic and inflammatory stimuli5–12.

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Authors
  1. C. Patrono
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  2. P. Patrignani
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  3. M. R. Panara
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  4. F. Cipollone
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  5. G. Santini
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  6. M. G. Sciulli
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  7. M. T. Rotondo
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  8. R. Padovano
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  9. M. Di Giamberardino
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Editor information

Editors and Affiliations

  1. The William Harvey Research Institute, Saint Bartholomew’s Hospital Medical College, London, UK

    John Vane , Jack Botting  & Regina Botting ,  & 

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© 1996 Kluwer Academic Publishers and William Harvey Press

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Patrono, C. et al. (1996). COX-2 expression and inhibition in human monocytes. In: Vane, J., Botting, J., Botting, R. (eds) Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9029-2_7

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  • DOI: https://doi.org/10.1007/978-94-010-9029-2_7

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-9031-5

  • Online ISBN: 978-94-010-9029-2

  • eBook Packages: Springer Book Archive

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