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Solution Conformations of Purine(ß)Nucleosides and Analogs

  • Conference paper
Nuclear Magnetic Resonance Spectroscopy in Molecular Biology

Part of the book series: The Jerusalem Symposia on Quantum Chemistry and Biochemistry ((JSQC,volume 11))

Abstract

The purinenucleosides and their natural or synthetic analogs are a class of compounds with a broad spectrum of physiological effects. Modification of a single side group at the base or ribose moiety can produce substances with antibiotic, antiviral, or antitumor activity. The biological activity of these analogs can only in part be explained through their different behaviour in the complex purinenucleoside metabolism (1,2). The study of the solution conformations of these derivatives could reveal purely sterical arguments for various modes of biological action of these substances, and might in addition help to understand the complex behaviour of the purinenucleosides in preparative chemistry (3). By application of the rich choice of CW and FTNMR-techniques to this class of compounds the preferred solution conformations can be derived.

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References

  1. A. Bloch, Ann.N.Y.Acad.Sci. Vol. 255, 1975

    Google Scholar 

  2. R.J. Suhadolnik, Nukleoside Antibiotics, Wiley Intersience N.Y., 1970

    Google Scholar 

  3. A. Williamson ed., Chemistry of Nucleic Acids Components Nucleic Acid Research, Spec.Publ.Nr. 1, 1975

    Google Scholar 

  4. P.O.P. Ts’o, Basic Principles in Nucleic Acid Chemistry, Vol. 1, 526, 1974

    Google Scholar 

  5. H.-D. Lüdemann, O. Röder, E. Westhof, E.V. Goldammer, A. Müller, Biophys.Struct.Mechanism 1, 121, 1975

    Article  Google Scholar 

  6. H.-D. Lüdemann, E. Westhof, O. Röder, Europ.J.Biochem. 49, 143, 1974

    Article  Google Scholar 

  7. H. Plach, E. Westhof, H.-D. Lüdemann, R. Mengel, Europ.J.Biochem. 80, 295, 1977

    Article  CAS  Google Scholar 

  8. J.P. Davis, P.A. Hart, Tetrahedron, Vol. 28, 2883, 1972

    Article  CAS  Google Scholar 

  9. H.-D. Lüdemann, E.V. Goldammer, Zeitschrift für Naturforschung 28c, 361, 1973

    Google Scholar 

  10. C. Altona, M. Sundaralingam, J.Amer.Chem.Soc. 94, 8205, 1972

    Article  CAS  Google Scholar 

  11. C. Altona, M. Sundaralingam, J.Amer.Chem.Soc. 95, 2333, 1973

    Article  CAS  Google Scholar 

  12. F.E. Hruska, The Jerusalem Symposia on Quantum and Biochemistry, Vol. V, 345 (E.D. Bergmann, B. Pullman eds.) 1973

    Google Scholar 

  13. C. Chachaty, G. Langlet, FEBS Letters, 68, 181, 1976

    Article  CAS  Google Scholar 

  14. K. Akasaka, T. Imoto, S. Shibata, H. Hatano, J.Magn.Res. 18, 328, 1975

    CAS  Google Scholar 

  15. D.B. Davis, studia biophysica, 55, 29, 1976

    Google Scholar 

  16. L.M. Rhodes, P.R. Schimmel, Biochem. 10, 4426, 1971

    Article  CAS  Google Scholar 

  17. O. Röder, H.-D. Lüdemann, E.V. Goldammer, Europ.J.Biochem. 53, 517, 1975

    Article  Google Scholar 

  18. D.E. Woessner, J.Chem.Phys. 36, 1, 1962

    Article  CAS  Google Scholar 

  19. A. Allerhand, R. Komorski, J.Amer.Chem.Soc. 95, 8228, 1973

    Article  CAS  Google Scholar 

  20. H. Plach, Dr.-Thesis, Universität Regensburg, 1978

    Google Scholar 

  21. E. Westhof, O. Röder, I. Croneiss, H.-D. Lüdemann, Zeitschrift für Naturforschung 30c, 131, 1974

    Google Scholar 

  22. H.-D. Lüdemann, E. Westhof, I. Cuno, Zeitschrift für Naturforschung 31c, 135, 1976

    Google Scholar 

  23. H.-D. Lüdemann, E. Westhof, Zeitschrift für Naturforschung 32c, 528, 1977

    Google Scholar 

  24. H.-D. Lüdemann, H. Plach, E. Westhof, L.B. Townsend, to be published

    Google Scholar 

  25. E. Westhof, H. Plach, I. Cuno, H.-D. Lüdemann, Nucleic Acid Research 4, 939, 1977

    Article  CAS  Google Scholar 

  26. K.N. Slessor, A.S. Tracey, Carbohydrate Res. 27, 407, 1973

    Article  CAS  Google Scholar 

  27. H.-D. Lüdemann, R. Mengel to be published

    Google Scholar 

  28. R.G.S. Ritchie, A.S. Perlin, Carbohydrate Res. 55, 121, 1977

    Article  CAS  Google Scholar 

  29. M. Sundaralingam, The Jerusalem Symposia on Quantum Chemistry and Biochemistry, Vol. V, 417 (E.D. Bergmann and B. Pullman eds.), 1973

    Google Scholar 

  30. S.S. Tavale, H.M. Sobell, J.Mol.Biol. 48, 109, 1970

    Article  CAS  Google Scholar 

  31. F.E. Evans, R.H. Sarma, J.Biol.Chem. 249, 4754, 1974

    CAS  Google Scholar 

  32. C. Chachaty, T. Zemb, G. Langlet, Tran-Dinh Son, H. Buc, M. Morange, Europ.J.Biochem. 62, 45, 1976

    Article  CAS  Google Scholar 

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Author information

Author notes

  1. E. Westhof

    Present address: Department of Biochemistry, University of Wisconsin, Madison, 53706, USA

Authors and Affiliations

  1. Institut für Biophysik und Physikalische Biochemie, Universität Regensburg, Postfach 397, D-8400, Regensburg, Germany

    H.-D. Lüdemann & E. Westhof

Authors
  1. H.-D. Lüdemann
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  2. E. Westhof
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Editor information

Editors and Affiliations

  1. Institut de Biologie Physico-Chimique (Fondation Edmond de Rothschild), Université Pierre et Marie Curie (Paris VI), Paris, France

    Bernard Pullman

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© 1978 D. Reidel Publishing Company, Dordrecht, Holland

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Lüdemann, HD., Westhof, E. (1978). Solution Conformations of Purine(ß)Nucleosides and Analogs. In: Pullman, B. (eds) Nuclear Magnetic Resonance Spectroscopy in Molecular Biology. The Jerusalem Symposia on Quantum Chemistry and Biochemistry, vol 11. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-9882-7_4

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  • DOI: https://doi.org/10.1007/978-94-009-9882-7_4

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-9884-1

  • Online ISBN: 978-94-009-9882-7

  • eBook Packages: Springer Book Archive

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