Abstract
Rates of postoperative bacterial infections are high in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) (1,2). These data suggest that host defence mechanisms may be impaired in the postoperative period. The purpose of this study is a reappraisal of the postoperative immune status in these patients since several investigations have reported its deficiency (3–5) while others found it normal (6,7).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Goodman, J.S., W., Schaffner, H.A., Collins, E.J., Battersby, M.G., Koenig, Infection after cardiovascular surgery: clinical study involving examination of antimicrobial prophylaxis. N. Engl. J. Med. 278: 117 (1968).
Iribarren, C.O.I., S., Ekeström, The causes of death after open heart surgery. J. thorac. cardiovasc. Surg. 47: 725 (1964).
Bowers, T.K., J., O’Flaherty, R.L., Simmons, H.S., Jacobs, Postsurgical granulocyte dysfunction: studies in healthy kidney donors. J. Lab. clin. Med. 90: 720 (1977).
Lundström, M., P., Olsson, P., Unger, S.,Ekeström, Effect of extracorporeal circulation on hematonoiesis and phagocytosis. J. cardiovasc. Surg. 4: 664 (1963).
Silva, J. Jr., H., Hoedsema, F.R. Jr., Fekety, Transient defects in phagocytosis functions during cardiopulmonary bypass. J. thorac. cardiovasc. Surg. 67: 175 (1974).
Kaplan, E.L., A.R., Castaneda, E.M., Ayoub, P.G., Quie, Effects of cardiopulmonary bypass on the phagocytic and bactericidal capacities of polymorphonuclear leukocytes. Circulation 37 (Suppl.II): 158 (1968).
Ros, A., M.E. Reverdy, J. Fleurette, P. Mikaeloff, Activité phagocytaire et bactéricide des polynucléaires sanguins chez des malades cardiaques opérés sous circulation extracorporelle. Nouv. Presse méd. 5:1490 (1976).
Kabat, E.A., M.M. Mayer, Experimental immunochemistry. 2nd Ed., Ch.C., Thomas, Springfield, pp 135–139 (1964).
Hakim, J., E. Cramer, P. Eoivin, H. Troube, J. Boucherot, Quantitative iodination of human blood polymorphonuclear leukocytes. Euroo. J. clin. Invest. 5:215 (1975).
Feliu, E., M.A. Gougerot, J. Hakim, E. Cramer, C. Auclair, B. Rueff, P. Boivin, Blood nolymornhonuclear dysfunction in patients with alcoholic cirrhosis. Europ. J. clin. Invest. 7:571 (1977).
Cramer, E., C. Auclair, J. Hakim, E. Feliu, J. Boucherot, H. Troube, J.F. Bernard, E. Bergogne, P. Boivin, Metabolic activity of ohagocytosing granulocytes in chronic granulocytic leukemia: ultrastructural observation of a degranulation defect. Blood 50:93 (1977).
Hairston, P., J.P. Manos, C.D. Graber, W.H.Jr. Lee, Depression of immunological surveillance by pump-oxygenation perfusion. J. surg. Res. 9:587 (1969).
Cohnen, G., Changes in immunoglobulin levels after surgical trauma. J. Trauma. 12:249 (1972).
Fuller, J.M., J.W. Keyser, Serum immunoglobulins after surgical operation. Clin. Chem. 21:667 (1975).
Gierhake, F.W., K. Ebert, P. Hagen, N. Papastravrou, L. Rickmeyer, R. Stocker, H.U. Valk, K. Zimmermann, Gerinnugsphysiologische und immunologische Moglichkeiten und Perspektiven zur Prophylaxe postoperativer Wundheilungsstorungen und Infektionen. Zbl. Chir. 100: 797 (1975).
Klein, W., G. Klein, Verhalten der Immunoglobuline IgA, IgG und IgM nach operativen Eingriffen am Herzen. Wien. med. Wschr., 120:298 (1970).
Lackner, F., Untersuchung von Parametern der zellulären und humoralen Abwehr gegen bakterielle. Infektion während Herzoperationen mit der Hrzlungmaschine. Acta Chir. austr. 16 (Suppl.):1 (1975).
Parker, D.J., J.W. Cantrell, R.B. Karp, R.M. Stroud, S.B. Digerness, Changes in serum complement and immunoglobulins following cardiopulmonary bypass. Surgery 71:824 (1972).
Vermesse, G., D. Camus, P. Wattre, A. Capron, C. Gautier-Benoit, Modifications immunitaires dans les suites opératoires immédiates. Nouv. Presse méd. 7:529 (1978).
Brinsfield, D.E., M.A. Hoof, R.B. Geering, Hematological changes in long-term perfusion. J. anol. Physiol. 17:531 (1962).
Lee, W.H.Jr., D. Krumhaar, E.W. Fonkalsrud, O.A. Schjeide, J.V.Jr. Maloney, Denaturation of plasma proteins as a cause of morbidity and death after intracardiac operations. Surgery 50:29 (1961).
Hakim, J., E. Cramer, C. Auclair, M.A. Gougerot, E. Feliu, P. Boivin, Acquired functional defect of human blood polymorohonuclear. In: Movement, metabolism and bactericidal mechanisms of phagocytes, Rossi, F., Patriarca, P.L., D. Romeo, Eds, Piccin Medical Books, Padua-London, pp 375–383 (1977).
Hakim, J., E. Cramer, M.A. Gougerot, Le polynucléaire neutrophile: système de défense de l’organisme. In: Le sang en anésthésie et réanimation, Conseiller, C., J.M. Desmonts, Eds, Arnette, Paris, pp 507–570 (1976).
Stossel, T.P., Phagocytosis (3 parts). New Engl. J. Med. 290:717,774,833 (1974).
Gallin, J.I., S.M. Wolff, Leukocyte chemotaxis: physiological considerations and abnormalities. Clin. Haemat. 4:567 (1975).
Stossel, T.P., Phagocytosis: a recognition and ingestion. Semin. Hemat. 12:83 (1975).
Klebanoff, S.J., Intraleukocytic microbicidal defects. Annu. Rev. Med. 22:39 (1971).
Babior, B.M., Oxygen-dependent microbial killing by phagocytes (firts of two parts). New Engl. J. Med. 298: 659 (1978).
Klebanoff, S.J., Antimicrobial mechanisms in neutroo_hilic polymorphonuclear leukocytes. Semin. Hemat. 12:117 (1975).
Klebanoff, S.J., C.B. Hamon, Role of myeloneroxidasemediated antimicrobial systems in intact leukocytes. J. Reticuloendothel. Soc. 12:170 (1972).
Bröte, L., O. Stendahl, The function of polymornhonuclear leukocytes after surgical trauma. Acta chir. scand, 141:565 (1975).
Park, B.H., S.M. Fikrig, E.M. Smithwick, Infection and nitroblue-tetrazolium reduction by neutrophils. A diagnostic aid. Lancet 2:532 (1968).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1979 ECSC, EEC, EAEC, Brussels-Luxembourg
About this chapter
Cite this chapter
Hakim, J., Gougerot-Pocidalo, MA., Lecompte, Y. (1979). Effects of Cardiac Surgery and Cardio-Pulmonary Bypass on Human Immune System. In: Schmid-Schönbein, H., Teitel, P. (eds) Basic Aspects of Blood Trauma. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-9337-2_16
Download citation
DOI: https://doi.org/10.1007/978-94-009-9337-2_16
Publisher Name: Springer, Dordrecht
Print ISBN: 978-90-247-2279-2
Online ISBN: 978-94-009-9337-2
eBook Packages: Springer Book Archive