Abstract
The pioneering work on TRH [1–4] inspired the staff of the Institute for Biomedical Research of the University of Texas at Austin to isolate concentrates of LHRH from tissue and conduct chemical and enzymic inactivation experiments toward determining certain amino acids in LHRH. These studies [5] resulted in the crucial conclusion that LHRH is a decapeptide rather than a nonapeptide [6]. These inactivation experiments not only provided accurate structural information, but were the basis for the synthesis of <Glu-Tyr-Arg-Trp-NH2 [7]. the first reported synthetic LHRH agonist. These early successes on TRH and LliRH were the basis for K. Folkers and C. Bowers to join in the transition to antagonists of LHRH.
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Folkers, K. et al. (1987). Specificity of Design to Achieve Antagonists of LHRH of Increasing Effectiveness in Therapeutic Activity. In: Vickery, B.H., Nestor, J.J. (eds) LHRH and Its Analogs. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3229-6_3
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DOI: https://doi.org/10.1007/978-94-009-3229-6_3
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