Abstract
A variety of peptides such as substance P, somatostatin, vasoactive intestinal peptide, gastrin, etc., have been reported to trigger the release of histamine from mast cells [1–5]. These cells are found in many tissues, notably skin, gingiva, lung and mesentery. They have prominent granules which contain histamine and other mediators of inflammation which can be released causing dilation of capillaries and increased vascular permeability. However, the finding by Schmidt et al. that a potent LHRH antagonist, [N-Ac-D-Nal(2)1,D-pF-Phe2, D-Trp3,D-Arg6]LHRH, produced transient edema of the face and extremities when administered subcutaneously to rats at 1.25 mg/kg, or 50–100 times the effective antiovulatory dose [6], had a significant impact on the development of LHRH antagonists as potential contraceptive agents. This observation suggested that LHRH analogs might release histamine and other inflammatory mediators from cells. Subsequently, accounts of in vitro histamine release by LHRH analogs were reported by Nekola et al.
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Karten, M.J. et al. (1987). In Vitro Histamine Release with LHRH Analogs. In: Vickery, B.H., Nestor, J.J. (eds) LHRH and Its Analogs. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3229-6_11
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DOI: https://doi.org/10.1007/978-94-009-3229-6_11
Publisher Name: Springer, Dordrecht
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