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Pathophysiologic mechanisms of aluminum toxicity: Aluminum-induced bone disease

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Aluminum and renal failure

Part of the book series: Developments in Nephrology ((DINE,volume 26))

Abstract

The accumulation of aluminum in tissues has been implicated in the pathogenesis of several clinical disorders of the musculoskeletal, central nervous, and hematologic systems [1–4]. Early clinical reports suggested that aluminum deposition in brain was related to the development of a progressive and lethal encephalopathy in patients receiving maintenance hemodialysis. Many patients with the syndrome of dialysis encephalopathy, or dialysis dementia, also exhibited clinical manifestations of a severe form of osteomalacia characterized by recurrent fractures and progressive muscle weakness [5,6]. This disorder was usually refractory to treatment with active vitamin D sterols, and several clinical and biochemical features distinguished it from other types of renal osteodystrophy [7–9]. Subsequent investigations documented that patients with concurrent manifestations of dialysis- associated osteomalacia and encephalopathy had extensive deposits of aluminum in bone [10, 11]. Water that contained aluminum and that was used for the preparation of hemodialysis solutions was the predominant source of aluminum loading in these patients [2, 12, 13].

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Authors
  1. William G. Goodman
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Editors and Affiliations

  1. University of Antwerp, Department of Nephrology-Hypertension, University Hospital Antwerp, Wilrijkstraat 10, B-2520, Edegem, Belgium

    Marc E. de Broe

  2. Nephrology Section (W111L), VA Medical Center West Los Angeles, University of California, Wilshire and Sawtelle Blvds, Los Angeles, CA, 90073, USA

    Jack W. Coburn

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© 1990 Kluwer Academic Publishers

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Goodman, W.G. (1990). Pathophysiologic mechanisms of aluminum toxicity: Aluminum-induced bone disease. In: de Broe, M.E., Coburn, J.W. (eds) Aluminum and renal failure. Developments in Nephrology, vol 26. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1868-9_7

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  • DOI: https://doi.org/10.1007/978-94-009-1868-9_7

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7333-2

  • Online ISBN: 978-94-009-1868-9

  • eBook Packages: Springer Book Archive

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