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Aluminium interaction with macromolecules and membranes

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Aluminum and renal failure

Part of the book series: Developments in Nephrology ((DINE,volume 26))

Abstract

In dilute aqueous solutions, at pH values below 3.5, aluminium salts dissolve to yield a triply-charged positive ion which interacts with solvent water to form the species [Al(H2O)6]3+, frequently written as Al3+. At physiological pH (7.4) in aqueous solution and in the absence of potential ligands other than water, the coordinated water molecules lose protons leading to the hydrolysed species [Al(OH)4]-, an aluminium ion tetrahedrally surrounded with four OH- groups. At intermediate pH values the species [Al(H2O)5(OH)]2+, [Al(H2O)4(OH)2]+ and [Al(OH)3] coexist. The exact proportions of each, which depend on the pH value of the solution, can in principle be calculated from their known stability constants [1]. However, at concentrations of Al3+ > 1 µM the low solubility of [Al(OH)3] in its amorphous form or as Gibbsite may be important.

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Authors
  1. Malcolm Cochran
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  2. John H. Coates
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  3. Daphne C. Elliott
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Editor information

Editors and Affiliations

  1. University of Antwerp, Department of Nephrology-Hypertension, University Hospital Antwerp, Wilrijkstraat 10, B-2520, Edegem, Belgium

    Marc E. de Broe

  2. Nephrology Section (W111L), VA Medical Center West Los Angeles, University of California, Wilshire and Sawtelle Blvds, Los Angeles, CA, 90073, USA

    Jack W. Coburn

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© 1990 Kluwer Academic Publishers

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Cochran, M., Coates, J.H., Elliott, D.C. (1990). Aluminium interaction with macromolecules and membranes. In: de Broe, M.E., Coburn, J.W. (eds) Aluminum and renal failure. Developments in Nephrology, vol 26. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1868-9_10

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  • DOI: https://doi.org/10.1007/978-94-009-1868-9_10

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7333-2

  • Online ISBN: 978-94-009-1868-9

  • eBook Packages: Springer Book Archive

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