Skip to main content

Abstract

The most widespread and common human filarial parasite is Wuchereria bancrofti, which currently infects around 100 million people in the humid tropics. The most common vector in towns is the ubiquitous tropical house mosquito, Culex quinquefasciatus; however, anopheline mosquitoes are important vectors in rural areas. The other major filarial parasite of humans transmitted by mosquitoes is Brugia malayi, which is patchily distributed in India and Southeast Asia. Mosquito-borne filariasis, widely known for the disfiguring elephantiasis which occurs in a proportion of cases, is still a major public health problem in the tropics. Considerable research effort has been expended on developing improved methods of chemotherapy, on immunodi-agnosis and on understanding the factors that influence transmission by mosquitoes.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  • Ash, L.R. and Riley, J.M. (1970) Development of Brugia pahangi in the jird, Meriones unguiculatus, with notes on infections in other rodents. J. Parasit.56, 962–968.

    Article  PubMed  CAS  Google Scholar 

  • Bosworth, W., Sullivan, J.J. and Chernin, E. (1976) Infective larvae of Brugia: Escape from mosquitoes into water and subsequent oral infectivity in jirds. Am. J. Trop. Med. Hyg.25, 700–703.

    PubMed  CAS  Google Scholar 

  • Crans, W.J. (1971) Mass separation of infective stage larvae from suspected mosquito vectors. Preliminary results of tests conducted in coastal Tanzania. WHO/FIL/71.96 (mimeographed document).

    Google Scholar 

  • Curtis, C.F., Ellis, D.S., Doyle, P.E., Ramji, B.D., Hill, N., Irungu, L.W. and Townson, H. (1983) Susceptibility of aposymbiotic Culex quinquefasciatus to Wuchereria bancrofti. J. Invert. Pathol.41, 214–223.

    Article  CAS  Google Scholar 

  • Denham, D.A., Dennis, D.T., Ponnudurai, T., Nelson, G.S. and Guy, F. (1971) Comparison of a counting chamber and thick smear methods of counting microfilariae. Trans. R. Soc. Trop. Med. Hyg.65, 521–526.

    Article  PubMed  CAS  Google Scholar 

  • Gerberg, E.J., Barnard, D.R. and Ward, R.A. (1994) Manual for mosquito rearing and experimental techniques. American Mosquito Control Association Bulletin No. 5 (revised.),

    Google Scholar 

  • Jin, L.Z. and Xu, J.J. (1991) Observations on the development of quantitatively inoculated Brugia malayi microfilariae in Anopheles sinensis and Culex quinquefasciatus. Chung Kuo Chi Sheng Chung Hsueh Yu Chi Sheng Chung Ping Tsa Chih9, 106–109 (in Chinese).

    Google Scholar 

  • Kilama, W.L. (1976) Variation in susceptibility of East African Aedes aegypti strains to Wuchereria bancrofti infection. E. African J. Med. Res.3, 127–132.

    Google Scholar 

  • Klowden, M.J. (1981) Infection of Aedes aegypti with Brugia pahangi administered by enema: results of quantitative infection and loss of infective larvae during blood feeding. Trans. R. Soc. Trop. Med. Hyg.75, 354–358.

    Article  PubMed  CAS  Google Scholar 

  • Lindsay, S J. and Denham, D.A. (1986) The ability of Aedes aegypti to survive and transmit infective larvae of Brugia pahangi over successive blood meals. J. Helminth.60, 159–168.

    Article  PubMed  CAS  Google Scholar 

  • McCall, J.W., Malone, J.B., Ah, H.S. and Thompson, P.E. (1973) Mongolian jirds (Meriones unguiculatus) infected with Brugia pahangi by the intraperitoneal route: a rich source of developing larvae, adult filariae and microfilariae. J. Parasitol.59, 436.

    Article  PubMed  CAS  Google Scholar 

  • Macdonald, W.W. (1971) The maintenance of vectors of filariasis. In Isolation and Maintenance of Parasites in vivo (A.E.R. Taylor and R. Muller, eds). Symp. Brit. Soc. Parasitol.9, 123–149.

    Google Scholar 

  • Macdonald, W.W. (1976) Mosquito genetics in relation to filarial infections. In Genetic aspects of Host-Parasite Relationships (A.E.R. Taylor and R. Muller, eds). Symp. Brit. Soc. Parasitol.14, 1–24.

    Google Scholar 

  • Macdonald, W.W. and Ramachandran, C.P. (1965) The influence of the gene fm (filarial susceptibility, Brugia malayi) on the susceptibility of Aedes aegypti to seven strains of Brugia, Wuchereria and Dirofilaria. Ann. Trop. Med. Parasitol.59, 64–73.

    PubMed  CAS  Google Scholar 

  • Macdonald, W.W. and Sheppard, P.M. (1965) Cross-over values in the sex chromosomes of the mosquito Aedes aegypti and evidence of the presence of inversions. Ann. Trop. Med. Parasitol.59, 74–87.

    PubMed  CAS  Google Scholar 

  • Minjas, J.N. and Townson, H. (1980) The successful cryopreservation of microfilariae with hydroxyethyl starch as cryoprotectant. Ann. Trop. Med. Parasitol.74, 571–573.

    PubMed  CAS  Google Scholar 

  • Munstermann, L.E. (1990) Gene map of the yellow fever mosquito Aedes (Stegomyia) aegypti. In Genetic Maps. Locus Maps of Complex Genomes (S.J. O’Brien, ed.), 5th edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.

    Google Scholar 

  • Paige, C.J. and Craig, G.B. (1975) Variation of filarial susceptibility among East African populations of Aedes aegypti. J. Med. Ent.12, 485–493.

    CAS  Google Scholar 

  • Rodriguez, P.H. and Craig, G.B. (1973) Susceptibility to Brugia pahangi in geographic strains of Aedes aegypti. Am. J. Trop. Med. Hyg.22, 53–61.

    PubMed  CAS  Google Scholar 

  • Schrater, A.F., Rossignol, P.A., Hamill, B., Piessens, W.F. and Spielman, A. (1982) Brugia malayi microfilariae from the peritoneal cavity of jirds vary in their ability to penetrate the mosquito midgut. Am. J. Trop. Med. Hyg.31, 292–296.

    PubMed  CAS  Google Scholar 

  • Southgate, B.A. (1973) Studies on filariasis in the Pacific: 1. A field trial of a counting-chamber technique for the determination of microfilarial rates and densities. South-east Asian J. Trop. Med. Hyg.4, 172–178.

    CAS  Google Scholar 

  • Terwedow and Rodriquez (1973) Development of Brugia pahangi in male mosquitoes. J. Parasitol.59, 222–223.

    Article  PubMed  Google Scholar 

  • Townson, H. (1974) The development of Brugia pahangi in male Aedes aegypti of ‘refractory’ genotype. Ann. Trop. Med. Parasitol.68, 239–240.

    PubMed  CAS  Google Scholar 

  • Townson, H. and Chaithong, U. (1991) Mosquito host influences on development of filariae. Ann. Trop. Med. Parasitol.85, 149–163.

    PubMed  CAS  Google Scholar 

  • Trpis, M. (1994) Aedes (Gymnometopa) mediovittatus (Diptera: Culicidae) as an experimental vector of Brugia pahangi and B.malayi (Spiruridae: Filariidae). J. Med. Ent.31, 442–444.

    CAS  Google Scholar 

  • Wade, J.O. (1976) A new design of membrane feeder incorporating an electrical blood stirring device. Ann. Trop. Med. Parasitol.70, 113–120.

    PubMed  CAS  Google Scholar 

  • Yates, J.A., Schmitz, K.A. and Rajan, T.V. (1994) Infectivity and normal development of third stage Brugia malayi maintained in vitro. J. Parasitol.80, 891–894.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Chapman & Hall

About this chapter

Cite this chapter

Townson, H. (1997). Infection of mosquitoes with filaria . In: Crampton, J.M., Beard, C.B., Louis, C. (eds) The Molecular Biology of Insect Disease Vectors. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1535-0_9

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-1535-0_9

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7185-7

  • Online ISBN: 978-94-009-1535-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics