Abstract
The most obvious hazard from the microbial contamination of medicines is infection, but more subtle degradative changes can occur which may also be clinically significant. These changes can include the biodegradation of formulation excipients leading to an alteration in the physicochemical characteristics of a product, or metabolism of the drug itself. Such drug transformations, while infrequently found in contaminated pharmaceutical products, are known to occur in the laboratory and after drug administration in vivo through the action of commensal organisms.
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© 1988 Elsevier Science Publishers Ltd
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Denyer, S.P. (1988). Clinical Consequences of Microbial Action on Medicines. In: Houghton, D.R., Smith, R.N., Eggins, H.O.W. (eds) Biodeterioration 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1363-9_19
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DOI: https://doi.org/10.1007/978-94-009-1363-9_19
Publisher Name: Springer, Dordrecht
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