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Experimental pancreas transplantation: a survey of relevant issues

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International Handbook of Pancreas Transplantation

Part of the book series: Developments in Surgery ((DISU,volume 10))

Abstract

The aim of pancreas transplantation is to provide for a source of endogenous insulin production in type 1 diabetics. The concept is that by this means normoglycemia will be maintained in a more physiologic fashion than by means of administration of exogenous insulin. This would ameliorate the quality of life not only by deleting the obligatory insulin injections and dietary restrictions, but also by yielding the best chance for the prevention or reduction of late complications such as retinopathy, nephropathy, neuropathy, and vascular disease.

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References

  1. Gayet R, Guillaume M: La régulation de la sécrétion interne pancréatique par un processus humoral, démontrée par des transplantations de pancréas. Expériences sur des animaux dépancréatés. C R Soc Biol 97: 1615 – 1618, 1927.

    CAS  Google Scholar 

  2. Brooks JR, Gifford GH: Pancreatic homotransplantation. Transplant Bull 6: 100 - 103, 1959.

    Article  PubMed  CAS  Google Scholar 

  3. DeJode LR, Howard JM: Studies in pancreaticoduodenal homotransplantation. Surg Gynec Obstet 114: 553 – 558, 1962.

    PubMed  CAS  Google Scholar 

  4. Reemtsma K, Lucas JF, Rogers RE, Schmidt FE, Davis FH: Islet cell function of the transplanted canine pancreas. Ann Surg 158: 645 – 654, 1963.

    Article  PubMed  CAS  Google Scholar 

  5. Bergan JJ, Hoehn JG, Porter N, Dry L: Total pancreatic allografts in pancreatectomized dogs. Arch Surg 90: 521 – 526, 1965.

    PubMed  CAS  Google Scholar 

  6. Largiader F, Lyons GW, Hidalgo F, Dietzman RH, Lillehei RC: orthotopic allotransplantation of the pancreas. Am J Surg 113: 70 – 76, 1967.

    Article  PubMed  CAS  Google Scholar 

  7. Mitchell RI, Rappaport AM, Davidson JK: Autotransplantation of the pancreas. Can J Surg 9: 192 – 198, 1966.

    PubMed  CAS  Google Scholar 

  8. Idezuki Y, Feemster JA, Dietzman RH, Lillehei RC: Experimental pancreaticoduodenal preservation and transplantation. Surg Gynec Obstet 126: 1002 – 1014, 1968.

    PubMed  CAS  Google Scholar 

  9. Aquino C, Ruiz JO, Schultz LS, Lillehei RC: Pancreatic transplantation without duodenum in the dog. Am J Surg 125: 240 – 244, 1973.

    Article  PubMed  CAS  Google Scholar 

  10. Toledo-Pereyra LH, Castellanos J, Lampe EW, Lillehei RC, Najarian JS: Comparative evaluation of pancreas transplantation techniques. Ann Surg 182: 567 – 571, 1975.

    Article  PubMed  CAS  Google Scholar 

  11. Cutfield RG, Kyriakides GK, Olson L, Condie RM, Mintz DH, Miller J: Late observations of canine segmental pancreatic autografts. Transplant Proc 16: 762 – 763, 1984.

    Google Scholar 

  12. Sutherland DER, Goetz FC, Najarian JS: One hundred pancreas transplants at a single institution. Ann Surg 200: 414 – 440, 1984

    Article  PubMed  CAS  Google Scholar 

  13. Idezuki Y, Goetz FC, Lillehei RC: Late effect of pancreatic duct ligation on beta cell function. Am J Surg 117: 33 – 39, 1969.

    Article  PubMed  CAS  Google Scholar 

  14. Dubernard JM, Traeger J, Neyra P, Touraine JL, Tranchant D, Blanc-Brunat N: A new method of preparation of segmental pancreatic grafts for transplantation: trials in dogs and in man. Surgery 84: 633 – 639, 1978.

    PubMed  CAS  Google Scholar 

  15. Sutherland DER: Pancreas and islet transplant registry statistics. Transplant Proc 16: 593 – 598, 1984.

    PubMed  CAS  Google Scholar 

  16. Van Schilfgaarde R, Lemkes HHPJ, Paul LC, Gooszen HG, Terpstra JL: Pancreas transplantation in The Netherlands: report of the first case. Neth J Surg 39: 29 – 31, 1987.

    PubMed  Google Scholar 

  17. Gooszen HG, Bosman FT, Van Schilfgaarde R: The effect of duct obliteration on the histology and endocrine function of the canine pancreas. Transplantation 38: 13 – 17, 1984.

    Article  PubMed  CAS  Google Scholar 

  18. Gooszen HG: Canine segmental pancreatic autotransplantation. An analysis of the effects of duct obliteration. Thesis, Leiden University. Pasmans,-s-Gravenhage, 1984. (ISBN 90- 9000830-6).

    Google Scholar 

  19. Gooszen HG, Van Schilfgaarde R, Frölich M, Van der Burg MPM: The effects of duct obliteration and of autotransplantation on the endocrine function of canine pancreatic segments. Diabetes 34: 1008 – 1013, 1985.

    Article  PubMed  CAS  Google Scholar 

  20. Gooszen HG, Van Schilfgaarde R, Terpstra JL: Arterial blood supply of the left lobe of the canine pancreas. II. Electromagnetic flow measurements. Surgery 93: 549 – 553, 1983.

    PubMed  CAS  Google Scholar 

  21. Van Schilfgaarde R, Gooszen HG: The persisting capability for vasodilatation in duct- occluded canine pancreatic segments. Horm Metab Res Suppl 13: 12 - 15, 1983.

    PubMed  Google Scholar 

  22. Dragstedt LR: Some physiologic problems in surgery of the pancreas. Ann Surg 118: 576 – 593, 1943.

    Article  PubMed  CAS  Google Scholar 

  23. Tydén G, Brattström C, Lundgren G, Ost L, Gunnarsson R, Ostman J, Groth CG: Pancreas transplantation in type 1 diabetes mellitus. Transplant Proc 18: 1753 – 1754, 1986.

    Google Scholar 

  24. Sollinger HW, Cook K, Kamps D, Glass NR, Belzer FO: Clinical and experimental experience with pancreaticocystostomy for exocrine pancreatic drainage in pancreas transplantation. Transplant Proc 16: 749 – 751, 1984.

    PubMed  CAS  Google Scholar 

  25. Sollinger HW, Kalayoglu M, Hoffman RM, Deierhoi MH, Belzer FO: Quadruple immunosuppressive therapy in whole pancreas transplantation. Transplant Proc 19: 2297 – 2299, 1987.

    PubMed  CAS  Google Scholar 

  26. Collin J: Current state of transplantation of the pancreas. Ann Roy Coll Surg 60: 21 – 27, 1978.

    CAS  Google Scholar 

  27. Florack G, Sutherland DER, Cavallini M, Najarian JS: Technical aspects of segmental pancreatic autotransplantation in dogs. Am J Surg 146: 565 – 574, 1983.

    Article  PubMed  CAS  Google Scholar 

  28. Van Schilfgaarde R, Gooszen HG, Overbosch EH, Terpstra JL: The arterial blood supply of the left lobe of the canine pancreas. I. Anatomical variations relevant to segmental transplantation. Surgery 93: 545 – 548, 1983.

    PubMed  Google Scholar 

  29. Calne RY, McMaster P, Rolles K, Duffy TJ: Technical observations in segmental pancreas allografting: observations on pancreatic blood flow. Transplant Proc 12 (suppl 2): 51 – 57, 1980.

    PubMed  CAS  Google Scholar 

  30. Bewick M, Mundy AR, Eaton B, Watson F: Endocrine function of the heterotopic pancreatic allotransplant in dogs. III. The cause of hyperinsulinemia. Transplantation 31: 23 – 25, 1981.

    Article  PubMed  CAS  Google Scholar 

  31. Pozza G, Traeger J, Dubernard JM, Secchi A, Pontiroli AE, Bosi E, Malik MC, Ruiton A, Blanc-Brunat N: Endocrine responses of type 1 (insulin-dependent) diabetic patients following successful pancreas transplantation. Diabetologia 24: 244 – 248, 1983.

    Article  PubMed  CAS  Google Scholar 

  32. Van Goor Hm, Slooff MJH, Sluiter WJ, Wijffels RTM: Changes in beta-cell response after segmental pancreatic autotransplantation. Transplant Proc 18: 1790 – 1791, 1986.

    Google Scholar 

  33. Brons IGM, Calne RY, Rolles K, Lobo A, Evans DB: Paratopic segmental pancreas with simultaneous kidney transplantation in diabetics. Transplant Proc 18: 1757 – 1758, 1986.

    Google Scholar 

  34. Idezuki Y, Goetz FC, Kaufman SE, Lillehei RC: In vitro insulin productivity of the preserved pancreas: a simple test to assess the viability of pancreatic allografts. Surgery 64: 940 – 947, 1968.

    PubMed  CAS  Google Scholar 

  35. Idezuki Y, Goetz FC, Lillehei RC: Experimental allotransplantation of the preserved pancreas and duodenum. Surgery 65: 485 – 493, 1969.

    PubMed  CAS  Google Scholar 

  36. De Gruyl J, Westbroek DL, MacDicken I, Ridderhoff E, Verschoor L, Van Strik R: Cryoprecipitated plasma perfusion preservation and cold storage preservation of duct-ligated pancreatic allografts. Br J Surg 64: 490 – 493, 1977.

    Article  PubMed  Google Scholar 

  37. Florack G, Sutherland DER, Heil J, Zweber B, Najarian JS: Long-term preservation of segmental pancreas autografts. Surgery 92: 260 – 269, 1982.

    PubMed  CAS  Google Scholar 

  38. Florack G, Sutherland DER, Heil J, Squifflet JP, Najarian JS: Preservation of canine segmental pancreatic autografts: cold storage versus pulsatile machine perfusion. J Surg Res 34: 493 – 504, 1983.

    Article  PubMed  CAS  Google Scholar 

  39. Largiader F, Baumgartner D, Uhlschmid G: Ischemia tolerance of human pancreatic transplants. Transplant Proc 16: 1285 – 1286, 1984.

    Google Scholar 

  40. Dafoe DC, Campbell DA, Marks WH, Borgstrom A, Marion RM, Berlin RE, Turcotte JG: Detrimental effects of four hours of cold storage on porcine pancreaticoduodenal transplantation. Surgery 99: 170 – 177, 1986.

    PubMed  CAS  Google Scholar 

  41. De Gruyl J, Westbroek DL, Dijkhuis CM, Vriesendorp HM, MacDicken I, Elion-Gerritsen W, Verschoor L, Hulsmans HAM, Horchner P: Influence of DLA-matching, ALS, and 24-hour preservation on isolated pancreas allograft survival. Transplant Proc 5: 755 – 759, 1973.

    PubMed  Google Scholar 

  42. Kyriakides GK, Rabinovitch A, Mintz D, Olson L, Rappaport FT, Miller J: Long-term study of vascularized free-draining intraperitoneal pancreatic segmental allografts in beagle dogs. J Clin Invest 67: 292 – 303, 1981.

    Article  PubMed  CAS  Google Scholar 

  43. Klempnauer J, Hoins L, Steiniger B, Gunther E, Wonigeit K, Pichlmayr R: Evidence for a differential importance of MHC and non-MHC alloantigens in pancreas and heart transplantation in the rat. Transplant Proc 16: 778 – 780, 1984.

    Google Scholar 

  44. Woehrle M, Markman JF, Silvers WK, Barker CF, Naji A: Effect of temperature of pretransplant culture on islet allografts in BB rats. Transplant Proc 18: 1845 – 1847, 1986.

    Google Scholar 

  45. Schulk JA, Drevyanko TF: Experimental pancreas allograft rejection: correlation between histologic and functional rejection and the efficacy of antirejection therapy. Surgery 98: 330 – 337, 1985.

    Google Scholar 

  46. Prieto M, Sutherland DER, Fernandez-Cruz L, Heil J, Najarian JS: Early diagnosis and treatment of rejection in pancreas transplantation. Transplant Proc 18: 1805 – 1806, 1986.

    Google Scholar 

  47. Severyn W, Olson L, Miller J, Kyriakides G, Rabinovitch A, Flaa C, Mintz D: Studies on the survival of simultaneous canine renal and segmental pancreatic allografts. Transplantation 33: 606 – 612, 1982.

    Article  PubMed  CAS  Google Scholar 

  48. Steiner E, Hammer C, Land W, Gruner P, Schneeberger H, Stangl M, Steimer W: Fine needle biopsy of canine pancreas graft: an attempt at cytologic diagnosis in graft rejection. Transplant Proc 16: 789 – 790, 1984.

    Google Scholar 

  49. Sollinger HW, Lieberman LM, Kamps D, Warner T, Cook K: Diagnosis of early pancreas allograft rejection with indium-lll-oxine-labeled platelets. Transplant Proc 16: 785 – 788, 1984.

    PubMed  CAS  Google Scholar 

  50. Jurewicz WA, Buckels JAC, Dykes JGA, Gunson BK, Hawker RJ, Chandler ST, McCollum CN, McMaster P: Indium-Ill labeled platelets in monitoring pancreatic transplants in humans. Transplant Proc 16: 720 – 723, 1984.

    PubMed  CAS  Google Scholar 

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© 1989 Kluwer Academic Publishers

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Schilfgaarde, R.V. (1989). Experimental pancreas transplantation: a survey of relevant issues. In: Dubernard, J.M., Sutherland, D.E.R. (eds) International Handbook of Pancreas Transplantation. Developments in Surgery, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1083-6_3

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  • DOI: https://doi.org/10.1007/978-94-009-1083-6_3

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6977-9

  • Online ISBN: 978-94-009-1083-6

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