Summary
Serotonin (5-hydroxytryptamine; 5-HT) excites neurons in the hypoglossal and solitary tract nuclei through 5-hydroxytryptamine 2 (5-HT2) receptors, and contributes to genioglossal muscle activation, hypotension and bradycardia. This study investigated the influence of 5-HT2 receptor-mediated 5-HT action in the hypoglossal and solitary tract nuclei on respiratory variables, particularly airway resistance. Adult male mice were subjected to microdialysis and placed in a double-chamber plethysmograph. 5-HT release and respiratory variables were assessed in response to fluoxetine perfusion or fluoxetine plus LY-53857 coperfusion of the dorsomedial medulla oblongata (DMM), which includes the hypoglossal and solitary tract nuclei. 5-HT release in the DMM was increased but respiratory rate was not affected by fluoxetine perfusion with or without LY-53857. Specific airway resistance was significantly larger with fluoxetine plus LY-53857 coperfusion than at baseline or during perfusion with fluoxetine. Conversely, tidal volume was significantly lower with fluoxetine plus LY-53857-coperfusion than at baseline. These results suggest that 5-HT release in the DMM is regulated by a suppressive effect of local 5-HT transporter activity, which elicits airway dilation and increases tidal volume through local 5-HT2 receptors without affecting respiratory rate.
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Kanamaru, M., Homma, I. (2009). Serotonin release acts on 5-HT2 receptors in the dorsomedial medulla oblongata to elicit airway dilation in mice. In: Shioda, S., Homma, I., Kato, N. (eds) Transmitters and Modulators in Health and Disease. Springer, Tokyo. https://doi.org/10.1007/978-4-431-99039-0_9
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DOI: https://doi.org/10.1007/978-4-431-99039-0_9
Publisher Name: Springer, Tokyo
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