Skip to main content
SpringerLink
Log in

Pathology of cholangiocellular carcinoma

  • Chapter
Primary Liver Cancer in Japan

Abstract

Cholangiocellular carcinoma (CCC) is an intrahepatic malignant tumor composed of cells resembling the biliary epithelium [1, 2]. A majority of CCC arise in the biliary lining epithelial cells, but it can also occur in the intrahepatic peribiliary glands [3] and also in Hering’s ductules [4, 5]. Carcinoma arising under pre-existing pathologic conditions or anomalies of biliary epithelial cells, such as von Meyenburg’s complexes or benign cysts, is also included in CCC [6–9].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Gibson JB, Sobin LH (1978) Histological typing of tumours of the liver, biliary tract and pancreas. World Health Organization, Geneva

    Google Scholar 

  2. Sugihara S, Kojiro M (1987) Pathology of cholangiocarcinoma. In: Okuda K, Ishka K (eds) Neoplasms of the liver. Springer-Verlag, Tokyo, pp 143–158

    Google Scholar 

  3. Terada T, Nakanuma Y (1990) Pathological observations of intrahepatic peribiliary glands in 1000 consecutive autopsy livers: A possible source of cholangiocarcinoma. Hepatology 12: 92–97

    Article  Google Scholar 

  4. Steiner PE, Higginson J (1959) Cholangiocellular carcinoma. Cancer 12: 753–759

    Article  PubMed  CAS  Google Scholar 

  5. Craig JR, Peters RL, Edmondson HA (1989) Tumors of the liver and intrahepatic bile ducts. Armed Forces Institute of Pathology, Washington DC, vol 26 pp 197–222

    Google Scholar 

  6. Nakanuma Y, Terada T, Tanaka Y, Ohta G (1985) Are hepatolithiasis and cholangiocarcinoma etiologically related? A morphological study of 12 cases of hepatolithiasis with cholangiocarcinoma. Virchows Arch [A] 406: 45–58

    Article  CAS  Google Scholar 

  7. Imamura M, Miyashita T, Tani T, Naito A, Tobe T, Takahashi K (1984) Cholangiocellular carcinoma associated with multiple liver cysts. Am J Gastroenterol 79: 790–795

    PubMed  CAS  Google Scholar 

  8. Flavell DJ (1981) Liver-fluke infection as an etiological factor in bile-duct carcinoma of man. Trans R Soc Trop Med Hyg 75: 814–824

    Article  PubMed  CAS  Google Scholar 

  9. Homer LW, White HJ, Read RC (1968) Neoplastic transformation of von Meyenburg complexes of the liver. J Pathol Bact 96: 499–502

    Article  CAS  Google Scholar 

  10. Anthony PP (1979) Hepatic neoplasms. In: RNM MacSween, PP Anthony, PJ Scheuer (eds) Pathology of the liver. Churchill Livingstone, Edinburgh, pp 387–413

    Google Scholar 

  11. The Liver Cancer Study Group of Japan (1980) Primary liver cancers in Japan. Cancer 45: 2663–2669

    Article  Google Scholar 

  12. Mori W, Nagasako K (1976) Cholangiocarcinoma and related lesions. In: Okuda K, Peters RL (eds) Hepatocellular carcinoma. Wiley, New York, pp 227–246

    Google Scholar 

  13. Okuda K, Kubo Y, Okazaki N, Arishima T, Hashimoto M, Jinnouchi S, Sawa Y, Shimokawa Y, Nakajima Y, Noguchi T, Nakano M, Kojiro M, Nakashima T (1977) Clinical aspects of intrahepatic bile duct carcinoma including hilar carcinoma. A study of 57 autopsy-proven cases. Cancer 39: 232–246

    Article  PubMed  CAS  Google Scholar 

  14. Kamiyama Y, Tobe T (1987) Treatment of primary liver cancer in Japan. In: Okuda K, and Ishak K (eds) Neoplasms of the liver. Springer-Verlag, Tokyo, pp 375–380

    Google Scholar 

  15. Healey JE, Schroy PC (1953) Anatomy of the biliary ducts within the human lives. Arch Surg 66: 599–616

    Article  Google Scholar 

  16. Terada T, Nakanuma Y, Ohta G (1987) Glandular elements around the intrahepatic bile ducts in man; their morphology and distribution in normal livers. Liver 7: 1–8

    PubMed  CAS  Google Scholar 

  17. Nakanuma Y, Ohta G (1979) Histometric and serial section observations of the intrahepatic bile ducts in primary biliary cirrhosis. Gastroenterology 76: 1326–1332

    PubMed  CAS  Google Scholar 

  18. Japanese Biliary Surgical Society (1981) General rules for surgical studies on cancer of biliary tract. Kanehara, Tokyo

    Google Scholar 

  19. Liver Cancer Study Group of Japan (1987) The general rules for the clinical and pathological study of primary liver cancer (2nd edn) Kanehara, Tokyo

    Google Scholar 

  20. Klatskin G (1965) Adenocarcinoma of the hepatic duct at its bifurcation within the porta hepatis. Am J Med 38: 241–256

    Article  PubMed  CAS  Google Scholar 

  21. Bosma A (1990) Surgical pathology of cholangiocarcinoma of the liver hilus (Klatskin tumor). Semin Liver Dis 10: 85–90

    Article  PubMed  CAS  Google Scholar 

  22. Eggel H (1901) Uber das Carcinom der Leber. Beitr. z Path Anat u z allgem Pathol 30: 506–604

    Google Scholar 

  23. Nakajima T, Kondo Y, Miyazaki M, Okui K (1988) A histopathologic study of 102 cases of intrahepatic cholangiocarcinoma: Histologic classification and modes of spreading. Hum Pathol 19: 1228–1234

    Google Scholar 

  24. Nakajima T, Kondo Y (1990) A clinicopathologic study of intrahepatic cholangiocarcinoma containing a component of squamous cell carcinoma. Cancer 65: 1401–1404

    Article  PubMed  CAS  Google Scholar 

  25. Hayashi M, Sugiura H, Ohta G, Shimazaki H, Kyoui Y, Nakanuma Y (1988) Cholangiocellular carcinoma with negative mucin staining (in Japanese). Jap J Gastroenterol 85: 1555–1558

    CAS  Google Scholar 

  26. Ho JCI (1980) Two cases of mucoepidermoid carcinoma of the liver. Pathology 12: 123–128

    Article  PubMed  CAS  Google Scholar 

  27. Arase Y, Endo Y, Kumada H, Ikeda K, Yoshiba A (1988) Hepatic squamous cell carcinoma with hypercalcemia in liver cirrhosis. Acta Pathol Jpn 38: 643–650

    PubMed  CAS  Google Scholar 

  28. Sasaki M, Nakanuma Y, Nagai Y, Nonomura A (1991) An autopsy case of intrahepatic cholangiocarcinoma with sarcomatous transformation. J Clin Gastroenterol 13: 220–225

    Article  PubMed  CAS  Google Scholar 

  29. Terada T, Sasaki M, Nakanuma Y, Takeda Y, Masunaga T (in press) Hilar cholangiocarcinoma (Klatskin tumor) probably arising from intrahepatic peribiliary glands. J Clin Gastroenterol

    Google Scholar 

  30. Nakashima T, Kojiro M, Kawano Y, Shirai F, Takemoto N, Tomimatsu H, Kawasaki H, Okuda K (1982) Histologic growth pattern of hepatocellular carcinoma. Relationship to orcein (hepatitis B surface-antigen)-positive cells in cancer tissue. Hum Pathol 13: 563–568

    Google Scholar 

  31. Gold JA, Sostman HD, Burrell MI (1979) Cholangiocarcinoma with portal vein obstruction. Radiology 130: 15–20

    PubMed  CAS  Google Scholar 

  32. Terada T, Hoso M, Nakanuma Y, Ohta T, Makino Y (1989) Extrahepatic portal venous obstruction of different pathogenesis in pancreatic diseases: Report of 4 autopsy cases with chronic pancreatitis and pancreatic carcinoma. Gastroenterol Jpn 24: 414–420

    PubMed  CAS  Google Scholar 

  33. Wang J, Dhillon AP, Sankey EA, Wightman AK, Lewin JF, Scheuer PJ (1990) “Neuroendocrine” differentiation in primary neoplasms of the liver. J Pathol 163:61–67

    Article  Google Scholar 

  34. Nakajima T, Kondo Y (1989) Well-differentiated cholangiocarcinoma: diagnostic significance of morphologic and immunohistochemical parameters. Am J Surg Pathol 13: 569–573

    Article  PubMed  CAS  Google Scholar 

  35. Hurlimann J, Gardiol D (1991) Immunohistochemistry in the differential diagnosis of liver carcinomas. Am J Surg Pathol 15: 280–288

    Article  PubMed  CAS  Google Scholar 

  36. Zhang S, Wu W, Chen H, Zhang X, Cong W, Sho H (1989) Characteristics of the distribution of lectin receptors in intrahepatic cholangiocellular carcinoma. Histochem J 21: 296–300

    Article  PubMed  CAS  Google Scholar 

  37. Nakanuma Y, Unoura M, Noto H, Ohta G (1986) Human chorionic gonadotropin in primary liver carcinoma in adults: An immunohistochemical study. Virchows Arch [A] 409: 365–373

    Google Scholar 

  38. Nonomura A, Mizukami Y, Matsubara F, Izumi R, Nakanuma Y, Hayashi M, Watanabe K, Takayanagi N (1989) Human chorionic gonadotropin and alpha-fetoprotein in cholangiocarcinoma in relation to expression of p21: An immunohistochemical study. Liver 9: 205–215

    PubMed  CAS  Google Scholar 

  39. Goodman ZD, Ishak KG, Longloss JM, Sesterhenn IA, Rabin LL (1985) Combined hepatocellular–cholangiocarcinoma. A histologic and immunohistochemical study. Cancer 55: 124–135

    Article  PubMed  CAS  Google Scholar 

  40. Nakanuma Y, Sasaki M (1989) Expression of blood group-related antigens in the intrahepatic biliary tree and hepatocytes in normal livers and various hepatobiliary diseases. Hepatology 10: 174–178.

    Article  PubMed  CAS  Google Scholar 

  41. Hurliman J, Gardiol D (1991) Immunohistochemistry in the differential diagnosis of liver carcinomas. Am J Surg Pathol 15: 280–288

    Article  Google Scholar 

  42. Lai YS, Thung SN, Gerber MA, Chen ML, Schaffner F (1989) Expression of cytokeratins in normal and diseased livers and primary liver carcinoma. Arch Pathol Lab Med 113: 134–138

    PubMed  CAS  Google Scholar 

  43. Nakanuma Y, Yamaguchi K, Ohta G, Terada T, Japanese Study Group of Hepatolithiasis (1988) Pathologic features of hepatolithiasis in Japan. Hum Pathol 19: 1181–1186

    Article  PubMed  CAS  Google Scholar 

  44. Chou ST, Chan CW, Ng WL (1976) Mucin histochemistry of human cholangiocarcinoma. J Pathol 118: 165–170

    Article  PubMed  CAS  Google Scholar 

  45. Qualman SJ, Haupt HM, Bauer TW, Taxy JB (1984) Adenocarcinoma of the hepatic duct junction: A reappraisal of the histologic criteria of malingancy. Cancer 53: 1545–1551

    Article  PubMed  CAS  Google Scholar 

  46. Scheuer PJ (1988) Liver biopsy interpretation. 4th ed., Bailliere Tindall, London, Philadelphia, Toronto, Sydney, Tokyo

    Google Scholar 

  47. Weibern K, Mutum SS (1983) Pathological aspects of cholangiocarcinoma. J Pathol 139: 217–238

    Article  Google Scholar 

  48. Koga A, Ichimiya H, Yamaguchi K, Miyazaki K, Nakayama F (1985) Hepatolithiasis associated with cholangiocarcinoma. Possible etiologic signifiance. Cancer 55: 2826–2829

    Article  PubMed  CAS  Google Scholar 

  49. Terada T, Ishida F, Nakanuma Y (1989) Intrahepatic cholesterol stones associated with peripheral cholangiocellular carcinoma: An autopsy case. Am J Gastroenterol 84: 1434–1436

    PubMed  CAS  Google Scholar 

  50. Mizumoto R, Kawarada Y (1987) Diagnosis and treatment of cholangiocarcinoma and cystic adenocarcinoma of the liver. In: Okuda K, and Ishka K (eds) Neoplasms of the liver. Springer-Verlag, Tokyo, pp 381–396

    Google Scholar 

  51. Terada T, Nakanuma Y, Saito K, Kono N (1990) Biliary sludge and microcalculi in intrahepatic bile ducts. Morphologic and X-ray microanalytical observations in 18 among 1,179 consecutively autopsied livers. Acta Pathol Jpn 40: 894–901

    PubMed  CAS  Google Scholar 

  52. Kurumaya H, Terada T, Nakanuma Y (1990) ‘Metaplastic lesions’ in intrahepatic bile ducts in hepatolithiasis: A histochemical and immunohistochemical study. J Gastroenterol Hepatol 5: 532–538

    Article  Google Scholar 

  53. Rubel LR, Ishak KM (1982) Thorotrast-associated cholangiocarcinoma. An epidemiologic and clinicopathologic study. Cancer 50: 1408–1415

    Article  PubMed  CAS  Google Scholar 

  54. Kim YI, Yu ES, Kim ST (1989) Intraductal variant of peripheral cholangiocarcinoma of the liver with Clonorchis sinensis infection. Cancer 63: 187–197

    Google Scholar 

  55. Azizah N, Oaradubas FJ (1980) Cholangiocarcinoma coexisting with developmental liver cysts: A distinct entity different from liver cystadenocarcinoma. Histopathology 4: 391–400

    Article  PubMed  CAS  Google Scholar 

  56. Bloustein PA, Silverberg SG (1976) Squamous cell carcinoma originating in a hepatic cyst: Case report with a review of the hepatic cyst-carcinoma association. Cancer 38: 2002–2005

    Article  PubMed  CAS  Google Scholar 

  57. Wee A, Ludwig J, Coffey RJ, LaRusso NF, Wiesner RH (1985) Hepatobiliary carcinoma associated with primary sclerosing cholangitis and chronic ulcerative colitis. Hum Pathol 16: 719–726

    Article  PubMed  CAS  Google Scholar 

  58. Haworth AC, Manely PN, Groll A, Pace R (1989) Bile duct carcinoma and biliary tract dysplasia in chronic ulcerative colitis. Arch Pathol Lab Med 113: 434–436

    PubMed  CAS  Google Scholar 

  59. Wheeler DA, Edmondson HA (1985) Cystadenoma with mesenchymal stroma (CMS) in the liver and bile ducts. A clinicopathological study of 17 cases, 4 with malignant change. Cancer 56: 1434–1445

    Article  PubMed  CAS  Google Scholar 

  60. Okulski EG, Dolin BJ, Kandawalla NM (1979) Intrahepatic biliary papillomatosis. Arch Pathol Lab Med 103: 647–649

    PubMed  CAS  Google Scholar 

  61. Terada T, Mitsui T, Nakanuma Y, Miura S, Toya D (in press) Intrahepatic papillomatosis in nonobstructive intrahepatic biliary dilatations confined to the hepatic left lobe. Am J Gastroenterol

    Google Scholar 

  62. Ohta T, Konishi K, Higashino Y, Asano A, Izumi R, Nagakawa T, Kinami Y, Miyazaki I, Okada Y (1983) A case of mucinous biliary obstruction associated with multiple cholangiocarcinoma (in Japanese). Tan To Sui 4: 687–692

    Google Scholar 

  63. Kim YI, Kim ST, Lee GK, Choi BI (1990) Papillary cystic tumor of the liver. A case report with ultrastructural observation. Cancer 65: 2740–2746

    Article  PubMed  CAS  Google Scholar 

  64. Terada T, Nakanuma Y, Kakita A (1990) Pathologic observations of intrahepatic peribiliary glands in 1,000 consecutive autopsy livers: Heterotropic pancreas in the liver. Gastroenterology 98: 1333–1337

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Second Department of Pathology, Kanazawa University School of Medicine, 920, Kanazawa, Ishikawa, Japan

    Yasuni Nakanuma, Hiroshi Minato, Tetsuji Kida & Tadashi Terada

Authors
  1. Yasuni Nakanuma
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hiroshi Minato
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tetsuji Kida
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Tadashi Terada
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. 1st Department of Surgery, Faculty of Medicine, Kyoto University, 54-Shogoin Kawara-cho, 606, Sakyo-ku, Kyoto, Japan

    Takayoshi Tobe M. D. (Chairman and Professor) (Chairman and Professor)

  2. The First Department of Internal Medicine, Jikei University School of Medicine, 105, Minato-ku, Tokyo, Japan

    Haruo Kameda

  3. Department of Pathology, School of Medicine, Kitasato University, 228, Sagamihara, Japan

    Masahiko Okudaira

  4. First Department of Medicine, School of Medicine, Chiba University, 280, Chiba, Japan

    Masao Ohto

  5. Sanraku Hospital, 2-5 Kanda Surugadai, 101, Chiyoda-ku, Tokyo, Japan

    Yasuo Endo

  6. The Second Department of Surgery, Asahikawa Medical College, Nishikagura 4-5, 078, Asahikawa, Hokkaido, Japan

    Michio Mito

  7. The First Department of Surgery, Hyogo College of Medicine, 663, Nishinomiya, Hyogo, Japan

    Eizo Okamoto

  8. Second Department of Medicine, Kurume University School of Medicine, 830, Kurume, Japan

    Kyuichi Tanikawa

  9. First Department of Pathology, Kurume University School of Medicine, 830, Fukuoka, Japan

    Masamichi Kojiro

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer-Verlag Tokyo

About this chapter

Cite this chapter

Nakanuma, Y., Minato, H., Kida, T., Terada, T. (1992). Pathology of cholangiocellular carcinoma. In: Tobe, T., et al. Primary Liver Cancer in Japan. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68177-9_5

Download citation

  • DOI: https://doi.org/10.1007/978-4-431-68177-9_5

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68179-3

  • Online ISBN: 978-4-431-68177-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation