Summary
Objectives: Interferon (IFN) therapy is ineffective in about 20%–30% of chronic hepatitis C (CH-C) patients with low hepatitis C virus (HCV) RNA levels. Besides the serum HCV RNA level or HCV genotype, hepatic iron concentrations are thought to be correlated with the subsequent response to IFN therapy. In the present study, we evaluated serum iron, ferritin, and hepatic iron staining in patients with low HCV RNA levels as a predictive marker for IFN therapy. Methods: We evaluated 75 CH-C patients whose serum HCV RNA levels were below 1 million genome equivalent/ml as shown by a branched DNA signal amplification assay. Results: There were no significant differences with regards to age, sex, serum alanine aminotransferase levels, or serum iron concentrations between responders and nonresponders. The total iron score (TIS) was significantly higher in responders (P < 0.01), and multivariate analysis showed that TIS was an independent factor relating to the response to IFN therapy (P = 0.0062). The TIS correlated significantly with serum ferritin levels (r = 0.637, P < 0.001), but not with any other parameter. Conclusions: Among CH-C patients with low HCV RNA levels, the TIS of the liver may be used as a predictive marker for IFN therapy.
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References
Arber N, Konikoff FM, Moshkowitz M, Baratz M, Hallak A, Santo M, Halpern Z, Weiss H, Gilat T (1994) Increased serum iron and iron saturation without liver iron accumulation distinguish chronic hepatitis C from other chronic liver diseases. Dig Dis Sci 39: 2656–2659
Di Bisceglie A, Axiotis CA, Hoofnagle JH, Bacon BR (1992) Measurements of iron status in patients with chronic hepatitis [see comments]. Gastroenterology 102: 21082113
DAlba R, Piperno A, Fargino S, Roffi L, Fracanzani AL, Pozzi M, Morena R, Fiorelli G (1993) Increased iron stores are a common findings in chronic viral hepatitis. Hepatology 18: 228A
Van Thiel D, Friedlander L, Fagiuoli S, Wright HI, Irish W, Gavaler JS (1994) Response to interferon alpha therapy is influenced by the iron content of the liver. J Hepatol 20: 410–415
Clemente MG, Congia M, Lai ME, Lilliu F, Lampis R, Frau F, Frau MR, Faa G, Diana G, Dessi C, Melis A, Mazzoleni AP, Cornacchia G, Cao A, De Virgiliis S (1994) Effect of iron overload on the response to recombinant interferon-alfa treatment in transfusion-dependent patients with thalassemia major and chronic hepatitis C. J Pediatr 125: 123–128
Martinot PM, Marcellin P, Pouteau M, Castelnau C, Boyer N, Poliquin M, Degott C, Descombes I, Le Breton V, Milotova V, Benhamou JP, Erlinger S (1995) Pretreatment serum hepatitis C virus RNA levels and hepatitis C virus genotype are the main and independent prognostic factors of sustained response to interferon alfa therapy in chronic hepatitis C. Hepatology 22: 1050–1056
Orito E, Mizokami M, Nakano T, Terashima H, Nojiri O, Sakakibara K, Mizuno M, Ogino M, Nakamura M, Matsumoto Y, Miyata K, Lau JYN (1994) Serum hepatitis C virus RNA level as a predictor of subsequent response to interferon-alpha therapy in Japanese patients with chronic hepatitis C. J Med Virol 44: 410–414
Desmet VJ, Gerber M, Hoofnagle JH, Manns M, Scheuer PJ (1994) Classification of chronic hepatitis: diagnosis, grading and staging. Hepatology 19: 1513–1520
Deugnier YM, Turlin B, Powell LW, Summers KM, Moirand R, Fletcher L, Loreal O, Brissot P, Halliday JW (1993) Differentiation between heterozygotes and homozygotes in genetic hemochromatosis by means of a histological hepatic iron index: a study of 192 cases. Hepatology 17: 30–34
Olynyk JK, O’neill R, Britton RS, Bacon BR (1994) Determination of hepatic iron concentration in fresh and paraffin-embedded tissue: diagnostic implications. Gastroenterology 106: 674–677
Schwarz KB, Larroya S, Vogler C, Sippel CJ, Homan S, Cockrell R, Schulze I (1991) Role of influenza B virus in hepatic steatosis and mitochondrial abnormalities in a mouse model of Reye syndrome. Hepatology 13: 96–103
Farinati F, Cardin R, De Maria N, Della Libera G, Marafin C, Lecis E, Burra P, Floreani A, Cecchetto A, Naccarato R (1995) Iron storage, lipid peroxidation and glutathione turnover in chronic anti-HCV positive hepatitis. J Hepatol 22: 449–456
Bacon BR, Park CH, Brittenham GM, O’Neill R, Tavill AS (1985) Hepatic mitochondrial oxidative metabolism in rats with chronic dietary iron overload. Hepatology 5: 789–797
Bresters D, Cuypers HT, Reesink HW, Mauser-Bunschoten EP, Vanden Berg HM, Schaasberg WP, Wiber JC, Urdea MS, Neuwald P, Lelie PN (1994) Comparison of quantitative cDNA-PCR with the branched DNA hybridization assay for monitoring plasma hepatitis C virus RNA levels in haemophilia patients participating in a controlled interferon trial. J Med Virol 43: 262–268
Olynyk JK, Reddy KR, Di Bisceglie AM, Jeffers LJ, Parker TI, Radick JL, Schiff ER, Bacon BR (1995) Hepatic iron concentration as a predictor of response to interferon alfa therapy in chronic hepatitis C. Gastroenterology 108: 1104–1109
Barton AL, Banner BF, Cable EE, Bonkovsky HL (1995) Distribution of iron in the liver predicts the response of chronic hepatitis C infection to interferon therapy. Am J Clin Pathol 103: 419–424
Deugnier YM, Loreal O, Turlin B, Guyader D, Jouanolle H, Moirand R, Jacquelinet C, Brissot P (1992) Liver pathology in genetic hemochromatosis: a review of 135 homozygous cases and their bioclinical correlations. Gastroenterology 102: 2050–2059
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Ide, T., Akiyoshi, F., Sata, M., Uchimura, Y., Suzuki, H., Tanikawa, K. (2003). Hepatic Iron Staining in Chronic Hepatitis C Patients with Low HCV RNA Levels as a Predictive Marker for Interferon Therapy. In: Okita, K. (eds) HCV/Oxidative Stress and Liver Disease. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67005-6_8
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DOI: https://doi.org/10.1007/978-4-431-67005-6_8
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