Summary
Since current techniques yield uncertain results on deafferentation pain, chronic brain Stimulation may presumably be a valuable alternative method, without deterrent side-effects. Disappointing results with stimulation of the somato-sensory structures prompted the selection of the medial posterior inferior thalamus and adjascent brain stem for chronic stimulation in pain states of central origin. Six such cases are reported. Abolition of the hyperpathia and marked reduction in the deep background pain was achieved in 2 cases, and disappearance of the hyperpathia and moderate reduction in the deep pain was obtained in another 2, but none had complete alleviation of pain. The follow-up time ranged between 6 and 42 months. Reversal of analgesia by naloxone was not observed. Acute experimentally-induced pain was not modified by Stimulation.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Adams, J. E., Naloxone reversal of analgesia produced by brain Stimulation in the human. Pain 2 (1976), 161–166.
Adams, J. E., Hosobuchi, Y., Linchitz, R., The present status of implantable intracranial stimulators for pain. In: Clinical Neurosurgery, Vol. 24, pp. 247–261. Baltimore: Williams and Wilkins. 1977.
Fields, H., Basbaum, A., Brain-stem control of spinal pain transmission neurons. Ann. Rev. Physiol. 40 (1978), 217–248.
Goodman, S. J., Holcomb, V., Selective and prolonged analgesia in monkeys resulting from brain Stimulation. In: Advances in Pain Research and Therapy, Vol. 1., pp. 495–502 (Bonica, J., Fessard, D., eds.). New York: Raven Press. 1976.
Gybels, J., Cosyns, P., Modulation of clinical and experimental pain in man by electrical Stimulation of thalamic periventricular gray. In: Sensory functions of the skin, pp. 521–530 (Zotterman, Y., ed.). Oxford: Pergamon Press. 1976.
Gybels, J., Electrical Stimulation of the central gray for pain relief in humans: A critical review. In: Advances in Pain Research and Therapy, Vol. 3, in press (Bonica, J., Liebeskind, J., Fessard, D., eds.). New York: Raven Press. 1979.
Hosobuchi, Y., Adams, J. E., Rutkin, B., Chronic thalamic and internal capsule Stimulation for the control of central pain. Surg. Neurol. 4 (1975), 91–93.
Hosobuchi, Y., Central gray Stimulation for pain suppression in humans. In: Advances in Pain Research and Therapy, Vol. 3, in press (Bonica, J., Liebeskind, J., Fessard, D., eds.). New York: Raven Press. 1979.
Liebeskind, J. C., Guilbrand, G., Besson, J. M., Oliveras, J. L., Analgesia from electrical Stimulation of the periaqueductal gray matter in the cat: be- havioral observations and inhibitory effects on spinal cord interneurons. Brain Res.50 (1973), 441–446.
Martin Rodriguez, J. G., Obrador, S., Therapeutic electrical Stimulation of the brain. Biochemical changes induced in the ventricular cerebrospinal fluid with regard to opiate-like substances. In: Modern Concepts in Psychiatric Surgery, pp. 47–56 (Hitchcock, E. R., Ballantine, H. T., Meyerson, B. A., eds.). Amsterdam: Elsevier. 1979.
Mayer, D. J., Wolfle, T. L., Akil, H., Carder, B., Liebeskind, J. C., Analgesia from electrical Stimulation in the brainstem of the rat. Science 174 (1971), 1351–1354.
Mayer, D. J., Prince, D. D., Central nervous mechanisms of analgesia. Pain 2 (1976), 379–404.
Mazars, G. L., Intermittent Stimulation of nucleus ventralis posterolateralis for intractable pain. Surg. Neurol.4 (1975), 93–95.
Meyerson, B. A., Boethius, J., Carlsson, A. M., Percutaneous central gray Stimulation for cancer pain. Appl. Neurophysiol. 41 (1978), 57–65.
Meyerson, B. A., Boethius, J., Carlsson, A. M., Alleviation of malignant pain by electrical Stimulation in the periventricular-periaqueductal region. Pain relief as related to Stimulation sites. In: Advances in Pain Research and Therapy, Vol. 3, in press (Bonica, J., Liebeskind, J., Fessard, D., eds.). New York: Raven Press. 1979.
Nashold, B. S., Wilson, W. P., Slaughter, D., Sensations evoked by Stimulation in the midbrain of man. J. Neurosurg. 30 (1969), 14–24.
Reynolds, D. V., Surgery in the rat during electrical analgesia induced by focal brain Stimulation. Science 164 (1969), 444–445.
Richardson, D. E., Akil, H., Pain reduction by electrical brain Stimulation in man. Chronic self-administration in the periventricular gray matter. J. Neurosurg.47 (1977), 184–194.
Richardson, D. E., Akil, H., Long term results of periventricular gray self- stimulation. Neurosurg. 1 (1977), 199–202.
Schvarcz, J. R., Estimulacion cerebral cronica. Bol. Asoc. Argent. Neurocir.20 (1976), 60.
Schvarcz, J. R., Para-aqueductal mesencephalotomy for facial central pain. In: Neurosurgical Treatment in Psychiatry, Pain and Epilepsy, pp. 661–667 (Sweet, W. H., Obrador, S., Martin, J., eds.). Baltimore: University Park Press. 1977.
Schvarcz, J. R., Postherpetic craneofacial dysaesthesiae. Their management by stereotactic trigeminal nucleotomy. Acta Neurochir. (Wien) 39 (1977), 65–72.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1980 Springer-Verlag
About this paper
Cite this paper
Schvarcz, J.R. (1980). Chronic Self-Stimulation of the Medial Posterior Inferior Thalamus for the Alleviation of Deafferentation Pain. In: Gillingham, F.J., Gybels, J., Hitchcock, E., Rossi, G.F., Szikla, G. (eds) Advances in Stereotactic and Functional Neurosurgery 4. Acta Neurochirurgica Supplementum, vol 30. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8592-6_36
Download citation
DOI: https://doi.org/10.1007/978-3-7091-8592-6_36
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-81591-5
Online ISBN: 978-3-7091-8592-6
eBook Packages: Springer Book Archive