Morphology of white matter, subcortical, dementia in Alzheimer’s disease

Summary

Dementing disorders are not only caused by grey matter alterations but also by white matter lesions, either together with grey matter changes or as the sole change. In dementia of Alzheimer’s type white matter disease in the nature of a selective incomplete white matter infarction was found in around 60% of cases. It was regarded as being most likely due to regional hypoperfusion of the white matter and might therefore be prevented, halted or even partly reversed by therapy.