Zusammenfassung
Enuresis nocturna wird als Einnässen im Schlaf, funktionelle Harninkontinenz als Einnässen tags ab einem Alter von 5 Jahren nach Ausschluss organischer Ursachen definiert. Viele verschiedene Subtypen können differenziert werden. Eine genaue Diagnostik ist für eine spezifische, wirksame Therapie entscheidend. Für alle Formen der Enuresis nocturna und der funktionellen Harninkontinenz sind symptomorientierte, nichtpharmakologische Interventionen wegen der besseren Wirksamkeit zu bevorzugen. Eine Indikation zur Pharmakotherapie ergibt sich nur bei der Enuresis nocturna (vor allem mit Desmopressin), bei der Dranginkontinenz (Anticholinergika) und in den seltenen Fällen der Lachinkontinenz (Psychostimulanzien). Komorbide psychische Störungen, die 20–40 % der Kinder mit Enuresis und/oder Harninkontinenz betreffen, sind zu beachten.
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Literatur
Alloussi S, Mürtz G, Braun R et al. (2009) Efficacy, tolerability and safety of propiverine hydrochloride in comparison to oxbutinine in children with urge incontinence due to overactive bladder: results of a multicentre observational cohort study. BJU Int 106:550–556
Austin P, Bauer S, Bower W et al. (2016) The standardization of terminology of lower urinary tract function in children and adolescents: update report from the standardization committee of the international children’s continence society (ICCS). Neurourol Urodyn 35:471–481
Barroso U, Tourinho R, Lordelo P, Hoebeke P, Chase J (2011) Electrical stimulation for lower urinary tract dysfunction in children: a systematic review of the literature. Neurolurol Urodynam 30:1429–1436
Berry AK, Zderik S, Carr M (2009) Methylphenidate for giggle incontinence. J Urol 182(4 Suppl):2028–2032
Biederman J, Thisted RA, Greenhill LL, Ryan ND (1995) Estimation of the association between desipramine and the risk for sudden death in 5- to 14-year-old children. J Clin Psychiatry 56:87–93
Blais AS, Nadeau G, Moore K, Genois L, Bolduc S (2016) Prosepctive pilot study of mirabegron in pediatric patients with overactive bladder. Eur Urol 70:9–13
Bolduc S, Moore K, Nadeau G et al. (2010) Prospective open label study of solifenacin for overactive bladder in children. J Urol 184(4 Suppl):1668–1673
Caldwell PHY, Nankivell G, Sureshkumar P (2013) Simple behavioural interventions for nocturnal enuresis in children. Cochrane Database Syst Rev 7:Art No CD003637. https://doi.org/10.1002/14651858.CD003637.pub3
Caldwell PHY, Sureshkumar P, Wong WCF (2016) Tricyclic and related drugs for nocturnal enuresis in children. Cochrane Database Syst Rev 1:Art No CD002117. https://doi.org/10.1002/14651858.CD002117.pub2
Caldwell PHY, Codarini M, Stewart F, Hahn D, Sureshkumar P (2020) Alarm interventions for nocturnal enuresis in children. Cochrane Database Syst Rev 5:Art No CD002911. https://doi.org/10.1002/14651858.CD002911.pub3
Chang JH, Lee KY, Kim TB et al. (2011) Clinical and urodynamic effect of methylphenidate for the treatment of giggle incontinence. Neurourol Urodynam 30:1338–1342
Claßen M, von Gontard A et al (2021) S2k-Leitlinie Funktionelle (nicht-organische) Obstipation und Stuhlinkontinenz im Kindes- und Jugendalter (AWMF Registernummer 068-019) (AWMF-online)
De Bruyne P, De Guchtenare A, Van Herzeele Ch et al. (2014) Pharmacokinetics of desmopressin administered as tablet and oral lyophilisate formulation in children with monosymptomatic nocturnal enuresis. Eur J Pediatr 173:223–228
Deshpande AV, Caldwell PHY, Sureshkumar P (2012) Drugs for nocturnal enuresis in childrten (other than desmopressin). Cochrane Database Syst Rev 12:Art No CD002238. https://doi.org/10.1002/14651858.CD002238.pub2
Equit M, Sambach H, Niemczyk J, von Gontard A (2013) Ausscheidungsstörungen bei Kindern und Jugendlichen – ein Therapieprogramm zur Blasen- und Darmschulung. Hogrefe, Göttingen
Falkai P, Wittchen H-U (2015) American Psychiatric Association. Diagnostisches und Statistisches Manual Psychischer Störungen DSM-5. Hogrefe, Göttingen
Fernandes L, Martin D, Hum S (2018) A case of the giggles: diagnosis and management of giggle incontinence. Can Fam Physician 64:445–447
Ferring (2011) Fachinformation Minirin Lyophilisat. Rote Liste Service GmbH, Fachinfoservice, Berlin
Franco I (2007) Overactive bladder in children. Part I: pathophysiology. J Urol 178:761–768
Franco I, Austin P, Bauer S, von Gontard A, Homsy Y (ed) (2015) Pediatric incontinence: evaluation and clinical management. Wiley-Blackwell, Oxford, Hoboken
Franco I, Hiebeke P, Baka-Ostrowska M et al. (2020) Long-term efficacy and safety of solifenacin in pediatric patients aged 6 months to 18 years with neurogenic detrusor overactivity: results from the phase 3 prospective open-label studies. J Ped Urol 16:180.e1–180.e8
Gepertz S, Neveus T (2004) Imipramine for therapy resistant enuresis: a retrospective evaluation. J Urol 171:2607–2610
Glazener CMA, Evans JHC (2002) Desmopressin for nocturnal enuresis in children. Cochrane Database Syst Rev 3:Art No CD002112. https://doi.org/10.1002/14651858.CD002112
Hjälmas K, Hellström A, Mogren G, Läckgren G, Stenberg A (2001) The overactive bladder in children: a potential future indication for tolterodine. BJU Intern 87:569–574
Hoebeke P, De Pooter J, De Caestecker K et al. (2009) Solifenacin for therapy resistant overactive bladder. J Urol 182:2040–2044
Houts AC, Berman JS, Abramson H (1994) Effectiveness of psychological and pharmalogical treatments for nocturnal enuresis. J Consult Clin Psychol 62:737–745
Joinson C, Heron J, von Gontard A, the ALSPAC study team (2006) Psychological problems in children with daytime wetting. Pediatrics 118:1985–1993
Juul KV, Van Herzele C, De Bruyne P et al. (2013) Desmopressin melt improves response and compliance compared with tablet in treatment of primary monosymptomatic enuresis. Eur J Pediatr 172:1235–1242
Kilic N, Balkan E, Akgoz S, Sen N, Dogruyol H (2006) Comparison of the effectiveness and side-effects of tolterodine and oxybutynin in children with detrusor overactivity. Int J Urol 13:105–108
Kuwertz-Bröking E, von Gontard A (2021) S2k-Leitlinie Enuresis und nicht-organische (funktionelle) Harninkontinenz bei Kindern und Jugendlichen (AWMF Registriernummer 028-026) (AWMF online)
Kwak KW, Lee YS, Park KH, Baek M (2010) Efficacy of Desmopressin and enuresis alarm as first and second line treatment for primary monosymptomatic nocturnal enuresis: prospective randomized crossover study. J Urol 185:2521–2526
Lopez Pereira P, Miquelez C, Caffarati J, Estornell F, Anquera A (2003) Trospium chloride for the treatment of detrusor instablity in children. J Urol 170:1978–1981
Lundmark E, Neveus T (2009) Reboxetine in therapy-resistant enuresis: a retrospective evaluation. Scan J Urol Nephrol 43:365–368
Marschall-Kehrel D, Feustel C, Persson de Geeter C et al. (2009) Treatment of propiverine in children suffering from nonneurogenic overactive bladder and urinary incontinence: results from a randomized placebo-controlled phase 3 clinical trial. Eur Urol 55:729–738
Medhi B, Mittal N, Bansal D et al. (2013) Comparison of tolterodine with standard treatment in pediatric patients with non-neurogenic dysfunctional voiding/overactive bladder: a systematic review. Indian J Physiol Pharmacol 57:1511–1517
Nevéus T, Fonseca E, Franco I et al. (2020) Management and treatment of nocturnal enuresis – an updated standardization document from the International Children’s Continence Society. J Pediatr Urol 16:10–19
Neveus T, Tullus K (2008) Tolterodine and imipramine in refractory enuresis: a placebo-controlled cross-over study. Pediatr Nephrol 23:262–267
Newgreen D, Bosman B, Hollestein-Havelaar A et al. (2017) Solifenacin in children and adolescents with overactive bladder: results of a phase 3 randomised clinical trial. Eur Urol 71(3):483–490
NICE clinical guideline 111 (2010) Nocturnal enuresis – the management of bedwetting in children and young people. National Institute for Health and Clinical Excellence, London
Nieuwhof-Leppink AJ, Hussong J, Chase J et al. (2021) Definitions, indications and practice of urotherapy in children and adolescents: a standardization document of the International Children’s Continence Society (ICCS). J Pediatr Urol 17:172–181. https://doi.org/10.1016/j.jpurol.2020.11.006
Nijman RJ, Borgstein NG, Ellsworth P, Djurhuss JC (2005) Tolterodine treatment for children with symptoms or urinary urge incontinence suggestive of detrusor overactivity: results from 2 randomized, placebo controlled trials. J Urol 173:1334–1339
Nijman RJ, Borgstein NG, Ellsworth P, Siggard C (2007) Long-term tolerability of tolterodine extended release in children 5–11 years of age: results from a 12-month, open-label study. Eur Urol 52:1511–1516
Ohtomo Y (2017a) Atomoxetine ameliorates nocturnal enuresis with subclinical attention-deficit/hyperactivity disorder. Pediatr Int 59:181–184
Ohtomo Y (2017b) Clonidine may have a beneficial effect on refractory nocturnal enuresis. Pediatr Int 59:711–713
Rovner ES (2004) Trospium chloride in the management of overactive bladder. Drugs 64:2443–2446
Schäfer SK, Niemczyk J, von Gontard A et al. (2017) Standard urotherapy as first-line intervention for daytime incontinence: a meta-analysis. Eur Child Adolesc Psychiatry 27:949–964
Schatzberg AF, Cole JO, DeBattista C (2003) Manual of clinical psychopharmacology. American Psychiatric Publishing, Washington
Sher PK, Reinberg Y (1996) Successful treatment of giggle incontinence with methylphenidate. J Urol 156:656–658
Staskin D, Kay G, Tannenbaum C et al. (2010) Trospiumchloride has no effect on memory testing and is undectable in the central nervous system of older patients with overactive bladder. Int J Clin Pract 64:1294–1300
Sumner SR, Schuh KJ, Sutton VK, Lipetz R, Kelsey DK (2006) Placebo-controlled study of the effects of atomoxetine on bladder control in children with nocturnal enuresis. J Child Adolesc Psychopharmacol 16:699–671
van Kerrebroeck PEV (2002) Experience with the long-term use of desmopressin for nocturnal enuresis in children and adolescents. BJU Int 89:420–425
van Londen A, van Londen-Barensten M, van Son M, Mulder G (1995) Relapse rate and parental reaction after successful treatment of children suffering from nocturnal enuresis: a 2 ½ year follow-up of bibliotherapy. Beh Res Ther 33:309–311
von Gontard A (2013) The impact of DSM-5 and guidelines for assessment and treatment of elimination disorders. Eur Child Adolesc Psychiat 22(Suppl 1):S61–S67
von Gontard A (2014) Klassifikation der Enuresis/Enkopresis in der DSM-5. Z Kinder Jugendpsychiatr Psychother 42:109–113
von Gontard A (2018) Leitfaden Enuresis, 3. Aufl. Hogrefe, Göttingen
von Gontard A (2021) Ausscheidungsstörungen – Klassifikation und Definition nach ICD-11. Z Kinder Jugendpsychiatr Psychother 49:421–428
von Gontard A, Equit M (2015) Comorbidity of ADHD and incontinence in children. Eur Child Adolesc Psychiat 24:127–140
von Gontard A, Baeyens D, Van Hoecke E, Warzak W, Bachmann C (2011) Psychological and psychiatric issues in urinary and fecal incontinence. J Urol 185:1432–1437
WHO (2020) International Classification of Diseases – 11th edition (ICD-11). https://www.who.int/standards/classifications/classification-of-diseases
Wright A, Haddad M (2017) Electroneurostimulation for the management of bladder bowel dysfunction in childhood. Eur J Ped Neurol 21:67–74
Yang St, Chua ME, Bauer St et al. (2018) Diagnosis and management of bladder bowel dysfunction in children with urinary tract infections: a position statement from the International Children’s Continence Society. Ped Nephrol 33:2207–2219
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von Gontard, A. (2023). Enuresis und funktionelle Harninkontinenz. In: Gerlach, M., Mehler-Wex, C., Romanos, M., Walitza, S., Wewetzer, C. (eds) Neuro-/Psychopharmaka im Kindes- und Jugendalter. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-65267-1_16
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