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Störungen der Glukosetoleranz und Diabetes mellitus Typ 2

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Adipositas bei Kindern und Jugendlichen

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Zusammenfassung

Der Diabestes mellitus Typ 2 (T2DM), der sogenannte „Altersdiabetes“ wird zunehmend häufiger bei adipösen Jugendlichen beobachtet wird. Der T2DM tritt v. a. bei Afroamerikaner, Hispanier, Asiaten und Indianern und weitaus seltener bei Kaukasiern auf. Die Manifestation des T2DM ist meist asymptomatisch, sodass ein Screening in Risikogruppen wie extreme Adipositas, erstgradige Verwandten mit T2DM, Zeichen einer Insulinresistenz (arterieller Bluthochdruck, Fettstoffwechselstörung, polyzystisches Ovarsyndrom oder Acanthosis nigricans) sinnvoll erscheint. Die Behandlung der Wahl besteht in einer Lebensstilintervention, gefolgt von einer Behandlung mit Metformin. Neue Medikamente sind DPP-IV-Hemmer und GLP-1-Mimetika, welche jedoch für das Jugendalter noch nicht zugelassen sind. Ein großes klinisches Problem stellt fehlende Therapieadhärenz von Jugendlichen mit T2DM dar.

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Literatur

  • American Diabetes Association (2000) Type 2 diabetes in children and adolescents. Diabetes Care 23:381–389

    Article  Google Scholar 

  • Anonymous (2013) Diagnosis and classification of diabetes mellitus. Diabetes Care 36(Suppl 1):S67–S74

    Google Scholar 

  • Anonymous (2016) ISPAD clinical practice consensus guidelines 2014

    Google Scholar 

  • Arslanian S (2002) Type 2 diabetes in children: clinical aspects and risk factors. Horm Res 57(Suppl 1):19–28

    CAS  PubMed  Google Scholar 

  • Arslanian SA (2000) Type 2 diabetes mellitus in children: pathophysiology and risk factors. J Pediatr Endocrinol Metab 13(Suppl 6):1385–1394

    Article  Google Scholar 

  • Awa WL, Boehm BO, Rosinger S, Achenbach P, Ziegler AG, Krause S, Meissner T, Wiegand S, Reinehr T, Kapellen T, Karges B, Eiermann T, Schober E, Holl RW (2013) HLA-typing, clinical, and immunological characterization of youth with type 2 diabetes mellitus phenotype from the German/Austrian DPV database. Pediatr Diabetes

    Google Scholar 

  • Dabelea D, Bell RA, D’Agostino RB Jr, Imperatore G, Johansen JM, Linder B, Liu LL, Loots B, Marcovina S, Mayer-Davis EJ, Pettitt DJ, Waitzfelder B (2007) Incidence of diabetes in youth in the United States. JAMA 297:2716–2724

    Article  Google Scholar 

  • Drake AJ, Smith A, Betts PR, Crowne EC, Shield JP (2002) Type 2 diabetes in obese white children. Arch Dis Child 86:207–208

    Article  CAS  Google Scholar 

  • Ehehalt S, Wiegand S, Koerner A, Schweizer R, Liesenkoetter K, Partsch C, Blumenstock G, Spielau U, Denzer C, Wabitsch M, Ranke M, Neu A, Binder G, Kiess W, Reinehr T (2016) Diabetes screening in overweight and obese children and adolescents: choosing the right test. Eur J Pediatr. (im Druck)

    Google Scholar 

  • Fagot-Campagna A, Narayan KM, Hanson RL, Imperatore G, Howard BV, Nelson RG, Pettitt DJ, Knowler WC (1997) Plasma lipoproteins and incidence of non-insulin-dependent diabetes mellitus in Pima Indians: protective effect of HDL cholesterol in women. Atherosclerosis 128:113–119

    Article  CAS  Google Scholar 

  • Fagot-Campagna A, Pettitt DJ, Engelgau MM, Burrows NR, Geiss LS, Valdez R, Beckles GL, Saaddine J, Gregg EW, Williamson DF, Narayan KM (2000) Type 2 diabetes among North American children and adolescents: an epidemiologic review and a public health perspective. J Pediatr 136:664–672

    Article  CAS  Google Scholar 

  • Florez JC (2008) Clinical review: the genetics of type 2 diabetes: a realistic appraisal in 2008. J Clin Endocrinol Metab 93:4633–4642

    Article  CAS  Google Scholar 

  • Hagman E, Reinehr T, Kowalski J, Ekbom A, Marcus C, Holl RW (2013) Impaired fasting glucose prevalence in two nationwide cohorts of obese children and adolescents. Int J Obes

    Google Scholar 

  • Hagman E, Danielsson P, Brandt L, Ekbom A, Marcus C (2016) Association between impaired fasting glycaemia in pediatric obesity and type 2 diabetes in young adulthood. Nutr Diabetes 6:e227

    Article  CAS  Google Scholar 

  • Han JC, Lawlor DA, Kimm SY (2010) Childhood obesity. Lancet 375:1737–1748

    Article  Google Scholar 

  • Hood KK, Beavers DP, Yi-Frazier J, Bell R, Dabelea D, Mckeown RE, Lawrence JM (2014) Psychosocial burden and glycemic control during the first 6 years of diabetes: results from the SEARCH for Diabetes in Youth study. J Adolesc Health 55:498–504

    Article  Google Scholar 

  • Kiess W, Bottner A, Raile K, Kapellen T, Muller G, Galler A, Paschke R, Wabitsch M (2003) Type 2 diabetes mellitus in children and adolescents: a review from a European perspective. Horm Res 59(Suppl 1):77–84

    CAS  PubMed  Google Scholar 

  • Kleber M, Desousa G, Papcke S, Wabitsch M, Reinehr T (2010a) Impaired glucose tolerance in obese white children and adolescents: three to five year follow-up in untreated patients. Exp Clin Endocrinol Diabetes

    Google Scholar 

  • Kleber M, Lass N, Papcke S, Wabitsch M, Reinehr T (2010b) One-year follow-up of untreated obese white children and adolescents with impaired glucose tolerance: high conversion rate to normal glucose tolerance. Diabet Med 27:516–521

    Article  CAS  Google Scholar 

  • Liese AD, D’Agostino RB Jr, Hamman RF, Kilgo PD, Lawrence JM, Liu LL, Loots B, Linder B, Marcovina S, Rodriguez B, Standiford D, Williams DE (2006) The burden of diabetes mellitus among US youth: prevalence estimates from the SEARCH for Diabetes in Youth Study. Pediatrics 118:1510–1518

    Article  Google Scholar 

  • Lobstein T, Frelut ML (2003) Prevalence of overweight among children in Europe. Obes Rev 4:195–200

    Article  CAS  Google Scholar 

  • May AL, Kuklina EV, Yoon PW (2012) Prevalence of cardiovascular disease risk factors among US adolescents, 1999–2008. Pediatrics 129:1035–1041

    Article  Google Scholar 

  • Moss A, Klenk J, Simon K, Thaiss H, Reinehr T, Wabitsch M (2012) Declining prevalence rates for overweight and obesity in German children starting school. Eur J Pediatr 171:289–299

    Article  Google Scholar 

  • Owada M, Hanaoka Y, Tanimoto Y, Kitagawa T (1990) Descriptive epidemiology of non-insulin dependent diabetes mellitus detected by urine glucose screening in school children in Japan. Acta Paediatr Jpn 32:716–724

    Article  CAS  Google Scholar 

  • Reinehr T (2005) Clinical presentation of type 2 diabetes mellitus in children and adolescents. Int J Obes 29(Suppl 2):S105–S110

    Article  Google Scholar 

  • Reinehr T (2013) Type 2 diabetes mellitus in children and adolescents. World J Diabetes 4:270–281

    Article  Google Scholar 

  • Reinehr T, Andler W, Kapellen T, Kiess W, Richter-Unruh A, Schonau E, Seewi O, Heinze E, Wabitsch M (2005) Clinical characteristics of type 2 diabetes mellitus in overweight European caucasian adolescents. Exp Clin Endocrinol Diabetes 113:167–170

    Article  CAS  Google Scholar 

  • Reinehr T, Schober E, Wiegand S, Thon A, Holl R (2006) Beta-cell autoantibodies in children with type 2 diabetes mellitus: subgroup or misclassification? Arch Dis Child 91:473–477

    Article  CAS  Google Scholar 

  • Reinehr T, Widhalm K, l’Allemand D, Wiegand S, Wabitsch M, Holl RW (2009) Two-year follow-up in 21,784 overweight children and adolescents with lifestyle intervention. Obesity (Silver Spring) 17:1196–1199

    Article  Google Scholar 

  • Reinehr T, Kiess W, Kapellen T, Wiegand S, Holl RW (2010) Children with diabetes mellitus type 2 in Europe: an underserved population. Arch Dis Child 95:954

    Article  CAS  Google Scholar 

  • Reinehr T, Karges B, Meissner T, Wiegand S, Fritsch M, Holl RW, Woelfle J (2015a) Fibroblast growth factor 21 and fetuin-A in obese adolescents with and without type 2 diabetes. J Clin Endocrinol Metab. https://doi.org/10.1210/jc.2015-2192

  • Reinehr T, Woelfle J, Wiegand S, Karges B, Meissner T, Nagl K, Holl RW (2015b) Leptin but not adiponectin is related to type 2 diabetes mellitus in obese adolescents. Pediatr Diabetes

    Google Scholar 

  • Reinehr T, Wolters B, Knop C, Lass N, Holl RW (2015c) Strong effect of pubertal status on metabolic health in obese children: a longitudinal study. J Clin Endocrinol Metab 100:301–308

    Article  CAS  Google Scholar 

  • Reinehr T, Karges B, Meissner T, Wiegand S, Stoffel-Wagner B, Holl RW, Woelfle J (2016) Inflammatory markers in obese adolescents with type 2 diabetes and their relationship to hepatokines and adipokines. J Pediatr 173:131–135

    Article  CAS  Google Scholar 

  • Rodriguez BL, Fujimoto WY, Mayer-Davis EJ, Imperatore G, Williams DE, Bell RA, Wadwa RP, Palla SL, Liu LL, Kershnar A, Daniels SR, Linder B (2006) Prevalence of cardiovascular disease risk factors in U.S. children and adolescents with diabetes: the SEARCH for diabetes in youth study. Diabetes Care 29:1891–1896

    Article  Google Scholar 

  • Rosenbloom AL, Silverstein JH, Amemiya S, Zeitler P, Klingensmith GJ (2008) ISPAD clinical practice consensus guidelines 2006–2007. Type 2 diabetes mellitus in the child and adolescent. Pediatr Diabetes 9:512–526

    Article  CAS  Google Scholar 

  • Rotteveel J, Belksma EJ, Renders CM, Hirasing RA, Delemarre-Van de Waal HA (2007) Type 2 diabetes in children in the Netherlands: the need for diagnostic protocols. Eur J Endocrinol 157:175–180

    Article  CAS  Google Scholar 

  • Schober E, Holl RW, Grabert M, Thon A, Rami B, Kapellen T, Seewi O, Reinehr T (2005) Diabetes mellitus type 2 in childhood and adolescence in Germany and parts of Austria. Eur J Pediatr 164:705–707

    Article  Google Scholar 

  • Schober E, Rami B, Grabert M, Thon A, Kapellen T, Reinehr T, Holl RW (2009a) Phenotypical aspects of maturity-onset diabetes of the young (MODY diabetes) in comparison with Type 2 diabetes mellitus (T2DM) in children and adolescents: experience from a large multicentre database. Diabet Med 26:466–473

    Article  CAS  Google Scholar 

  • Schober E, Waldhoer T, Rami B, Hofer S (2009b) Incidence and time trend of type 1 and type 2 diabetes in Austrian children 1999–2007. J Pediatr 155:190–193

    Article  Google Scholar 

  • Sinha R, Fisch G, Teague B, Tamborlane WV, Banyas B, Allen K, Savoye M, Rieger V, Taksali S, Barbetta G, Sherwin RS, Caprio S (2002) Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. N Engl J Med 346:802–810

    Article  CAS  Google Scholar 

  • Springer SC, Silverstein J, Copeland K, Moore KR, Prazar GE, Raymer T, Shiffman RN, Thaker VV, Anderson M, Spann SJ, Flinn SK (2013) Management of type 2 diabetes mellitus in children and adolescents. Pediatrics 131:e648–e664

    Article  Google Scholar 

  • Taksali SE, Caprio S, Dziura J, Dufour S, Cali AM, Goodman TR, Papademetris X, Burgert TS, Pierpont BM, Savoye M, Shaw M, Seyal AA, Weiss R (2008) High visceral and low abdominal subcutaneous fat stores in the obese adolescent: a determinant of an adverse metabolic phenotype. Diabetes 57:367–371

    Article  CAS  Google Scholar 

  • Wabitsch M, Hauner H, Hertrampf M, Muche R, Hay B, Mayer H, Kratzer W, Debatin KM, Heinze E (2004) Type II diabetes mellitus and impaired glucose regulation in Caucasian children and adolescents with obesity living in Germany. Int J Obes Relat Metab Disord 28:307–313

    Article  CAS  Google Scholar 

  • Weiss R, Dziura J, Burgert TS, Tamborlane WV, Taksali SE, Yeckel CW, Allen K, Lopes M, Savoye M, Morrison J, Sherwin RS, Caprio S (2004) Obesity and the metabolic syndrome in children and adolescents. N Engl J Med 350:2362–2374

    Article  CAS  Google Scholar 

  • Wiegand S, l’Allemand D, Hubel H, Krude H, Burmann M, Martus P, Gruters A, Holl RW (2010) Metformin and placebo therapy both improve weight management and fasting insulin in obese insulin-resistant adolescents: a prospective, placebo-controlled, randomized study. Eur J Endocrinol 163:585–592

    Article  CAS  Google Scholar 

  • Zeitler P, Hirst K, Pyle L, Linder B, Copeland K, Arslanian S, Cuttler L, Nathan DM, Tollefsen S, Wilfley D, Kaufman F (2012) A clinical trial to maintain glycemic control in youth with type 2 diabetes. N Engl J Med 366:2247–2256

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Endokrinologie und Diabetologie, Vestische Kinderklinik, Datteln, Deutschland

    Thomas Reinehr

  2. Sektion Pädiatrische Endokrinologie u. Diabetologie, Universitätsklinik für Kinder- und Jugendmedizin, Ulm, Deutschland

    Eberhard Heinze & Martin Wabitsch

Authors
  1. Thomas Reinehr
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  2. Eberhard Heinze
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  3. Martin Wabitsch
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Correspondence to Thomas Reinehr .

Editor information

Editors and Affiliations

  1. Sektion Pädiatrische Endokrinologie u. Diabetologie, Universitätsklinik für Kinder- und Jugendmedizin, Ulm, Deutschland

    Martin Wabitsch

  2. Kinder- und Jugendpsychiatrie, Rheinische Kliniken der Universität Duisburg-Essen, Essen, Deutschland

    Johannes Hebebrand

  3. Klinik und Poliklinik für Kinder- und Jugendmedizin, Universitätsklinikum Leipzig, Leipzig, Deutschland

    Wieland Kiess

  4. Endokrinologie und Diabetologie, Vestische Kinderklinik, Datteln, Deutschland

    Thomas Reinehr

  5. Sozialpädiatrisches Zentrum, Charité – Universitätsmedizin Berlin, Berlin, Deutschland

    Susanna Wiegand

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Reinehr, T., Heinze, E., Wabitsch, M. (2022). Störungen der Glukosetoleranz und Diabetes mellitus Typ 2. In: Wabitsch, M., Hebebrand, J., Kiess, W., Reinehr, T., Wiegand, S. (eds) Adipositas bei Kindern und Jugendlichen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-59216-8_23

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  • DOI: https://doi.org/10.1007/978-3-662-59216-8_23

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