Zusammenfassung
Das Vulvakarzinom ist selten und tritt bevorzugt zwischen dem 60. und 70. Lebensjahr auf. Im Vordergrund der Therapie stehen die weite Exzision des Primärtumors im Gesunden und die histologische Beurteilung der inguinalen Lymphknoten. Die systematische inguinale Lymphadenektomie wird bei T1- und T2-Tumoren bei Vorliegen negativer Sentinel-Lymphknoten zunehmend von einer alleinigen Sentinel-Lymphknoten-Biopsie abgelöst. Diese weist eine Treffsicherheit von > 95 % auf Ca. 70 % der Patientinnen mit Vulvakarzinom kann so eine systematische inguinale Lymphadenektomie, die mit einer signifikanten Morbidität wie Lymphödemen behaftet ist, erspart werden. Eine primäre Radio-(Chemo-)Therapie kann bei großen Primärtumoren und/oder inguinalen Lymphknotenmetastasen häufig den Tumor in Remission bringen und damit exenterative Therapien umgehen.
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Tamussino, K., Trutnovsky, G., Petru, E. (2019). Maligne Tumoren der Vulva. In: Petru, E., Fink, D., Köchli, O., Loibl, S. (eds) Praxisbuch Gynäkologische Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-57430-0_12
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