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Vitaminmangel-Erkrankungen

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Neurologische Pathophysiologie
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Zusammenfassung

Vitaminmangel-Erkrankungen sind häufig auftretende Krankheitsbilder, die mit sehr heterogenen Symptomen einhergehen können. In diesem Kapitel werden beispielhaft die Folgen eines Vitamin-B1- als auch eines Vitamin-B12-Mangels erläutert und ihre pathophysiologischen Mechanismen dargestellt. Es wird auf die Rolle der beiden B-Vitamine im Zellstoffwechsel eingegangen und die Pathomechanismen infolge eines Mangels an den Vitaminen dargelegt. Zudem wird auf die Ursachen der Mangelerkrankungen verwiesen, die zumeist im Rahmen von Unter- oder Fehlernährung auftreten oder Folge gastrointestinaler Störungen sind. Die Ursachen typischer neurologischer Syndrome infolge des Vitaminmangels werden dargestellt und Komplikationen als auch die Prognose der Erkrankungen diskutiert.

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Literatur

Literatur zu Abschn. 5.1

  • Afadlal S, Labetoulle R, Hazell AS. Role of Astrocytes in thiamine deficiency (2014) Metab Brain Dis 29: 1061–1068

    Article  CAS  Google Scholar 

  • Baker KG, Harding AJ, Halliday GM, Kril JJ, Harper CG (1999) Neuronal loss in functional zones of the cerebellum of chronic alcoholics with and without Wernicke’s encephalopathy. Neuroscience 91 (2): 429–438

    Article  CAS  Google Scholar 

  • Desjardins P, Butterworth F (2005) Role of Mitochondrial Dysfunction and oxidative stress in the pathogenesis of selectve neuronal loss in Wernicke’s encephalopathy. Molecular Neurobiology 2005; 31: 17–25

    Article  CAS  Google Scholar 

  • Galvin R, Brathen G, Ivashynka A, Hillbom M, Tanasescu R, Leone MA (2010) EFNS guidelines for diagnosis, therapy and prevention of Wernicke encephalopathy. Eur J Neurol 17 (12): 1408–1418

    Article  CAS  Google Scholar 

  • Harper C. Wernicke’s encephalopathy: a more common disease than realised. (1979) A neuropathological study of 51 cases. J Neurol Neurosurg Psychiat 42 (3): 226–231

    Google Scholar 

  • Harper CG, Giles M, Finlay-Jones R (1986) Clinical signs in the Wernicke-Korsakoff complex: a retrospective analysis of 131 cases diagnosed at necropsy. J Neurol Neurosurg Psychiat 49 (4): 341–345

    Article  CAS  Google Scholar 

  • Hazell AS, Rama Rao KV, Canbolt NC, Pow DV, Butterworth RF (2001) Selective down-regulation of the astrocyte transporters GLT-1 and GLAST within the medial thalamus in experimental Wernicke’s encephalopathy. J Neurochem 78: 560–568

    Google Scholar 

  • Kröll D, Laimer M, Borbely MB, Laederach K, Candinas D, Nett PC (2015) Wernicke Encephalopathy: A future problem even after sleeve Gastrectomy? A systematic review. Obes Surg 26 (1): 2015–212

    Article  Google Scholar 

  • Latt N, Dore G (2014) Thiamine in the treatment of Wernicke encephalopathy in patients with alcohol use disorders. Intern Med J 44 (9): 911–5.

    Article  CAS  Google Scholar 

  • Manzanares W, Hardy G (2011) Thiamine supplementation in the critically ill. Curr Opin Clin Nutr Metab Care 14 (6): 610–617

    Article  CAS  Google Scholar 

  • Pittella JEH, Giannetti AV (1994) Morphometric study of the neurons in the medical mammillary nucleus in acute and chronic Wernicke’s encephalopathy. Clin Neuropathol 13 (1): 26–31

    Google Scholar 

  • Qin L, Crews FT (2014) Focal thalamic degeneration from ethanol and thiamine deficiency is associated with neuroimmune gene induction, microglial activation and lack of Monocarboxylic Acid Transporters. Alcohol Clin Exp Res 38, 3: 657–671

    Article  Google Scholar 

  • Rodríguez-Pardo J, Puertas-Muñoz I, Martínez-Sánchez P, Díaz de Terán J, Pulido-Valdeolivas I, Fuentes B (2015) Putamina involvement in Wernicke encephalopathy induced by Janus Kinase 2 inhibitor. Clin Neuropharmacol 38 (3): 117–8

    Google Scholar 

  • Scalzo SJ, Bowden SC, Ambrose ML, Whelan G, Cook MJ (2015) Wernicke-Korsakoff syndrome not related to alcohol use: a systematic review. J Neurol Neurosurg Psychiatry

    Google Scholar 

  • Schabelmann E, Kuo D (2012) Glucose before thiamine for Wernicke encephalopathy: A literature review. J Emerg Med 42 (4): 488–494

    Article  Google Scholar 

  • Sechi G, Serra A (2007) Wernicke’s encephalopathie: new clinical setting and recent advances in diagnosis and management. Lancet Neurol 6 (5): 442–55

    Article  CAS  Google Scholar 

  • Tran ND, Correale J, Schreiber SS, Fisher M (1999) Tranforming growth factor-beta mediates astrocyte-specific regulation of brain endothelial anticoagulant factors. Stroke 30: 1671–1678

    Article  CAS  Google Scholar 

Literatur zu Abschn. 5.2

  • Andrès E, Loukili NH, Noel E, Kaltenbach G, Abdelgheni MB, Perrin AE, Noblet-Dick M, Maloisel F, Schlienger JL, Blicklé JF (2004) Vitamin B12 (cobalamin) deficiency in elderly patients. CMAJ 171 (3): 251–259

    Article  Google Scholar 

  • Biesalski HK, Fürst P, Kasper H et al. (2004) Ernährungsmedizin. Nach dem Curriculum Ernährungsmedizin der Bundesärztekammer, 3. Aufl. Georg Thieme Verlag, Stuttgart

    Google Scholar 

  • Biesalski HK, Köhrle J, Schümann K (2002) Vitamine, Spurenelemente und Mineralstoffe. Prävention und Therapie mit Mikronährstoffen. Georg Thieme Verlag, Stuttgart

    Google Scholar 

  • Carmel R, Melnyk S, James SJ (2003) Cobalamin deficiency with and without neurologic abnormalities: differences in homocysteine and methionine metabolism. Blood 101 (8), 3302–3308

    Article  CAS  Google Scholar 

  • Durga J, van Boxtel MP et al. (2006) Folate and the methylenetetrahydrofolate reductase 677C -> T mutation correlate with cognitive performance. Neurobiol Aging 27 (2),334–343

    Article  CAS  Google Scholar 

  • Guéant JL, Caillerez-Fofou M, Battaglia-Hsu S, Alberto JM, Freund JN, Dulluc I, Adjalla C, Maury F, Merle C, Nicolas JP, Namour F, Daval JL (2013) Molecular and cellular effects of vitamin B12 in brain, myocardium and liver through its role as co-factor of methionine synthase. Biochimie 95 (5): 1033–40

    Article  Google Scholar 

  • Healton, EB, Savage, DG, Brust, JC, Garrett, TJ, Lindenbaum, J (1991) Neurologic aspects of cobalamin deficiency. Medicine70 (4), 229–245

    Google Scholar 

  • Hacke W (Hrsg) (2016) Neurologie, 14. Auflage. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Heinrich PC, Müller M, Graeve L (Hrsg) (2014) Löffler/Petrides: Biochemie und Pathobiochemie, 9. Aufl. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Herrmann W, Lorenzl S, Obeid R (2007) Hyperhomocysteinämie und B-Vitaminmangel bei neurologischen und psychiatrischen Erkrankungen. Aktueller Kenntnisstand und vorläufige Empfehlungen. Fortschr Neurol Psychiatr 75 (9): e1-e18

    Article  Google Scholar 

  • Lindenbaum J, Healton EB et al. (1988) Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or acrocytosis. New Engl J Med 318 (26): 1720–1728

    Article  CAS  Google Scholar 

  • Linn J, Wiesmann M, Brückmann H (Hrsg) (2011) Atlas der klinischen Neuroradiologie des Gehirns. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Mattson MP, Shea TB (2003) Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci 26 (3): 137–146

    Article  CAS  Google Scholar 

  • Renard D, Dutray A, Remy A, Castelnovo G, Labauge P (2009) Subacute combined degeneration of the spinal cord caused by nitrous oxide anaesthesia. Neurological Sci 30 (1), 75–76

    Article  Google Scholar 

  • Reynolds E (2006) Vitamin B12, folic acid, and the nervous system. Lancet Neurol 5 (11): 949–60

    Article  CAS  Google Scholar 

  • Saperstein DS, Wolfe GI, Gronseth GS, Nations SP, Herbelin LL, Bryan WW, Barohn RJ (2003). Challenges in the identification of cobalamin-deficiency polyneuropathy. Archives of neurology,60 (9)1296–1301

    Google Scholar 

  • Scalabrino G (2005) Cobalamin (vitamin B 12) in subacute combined degeneration and beyond: traditional interpretations and novel theories. Exp Neurol 192 (2): 463–479

    Google Scholar 

  • Singer MA, Lazaridis C, Nations SP, Wolfe GI (2008) Reversible nitrous oxide-induces myelinopathy with pernicious anemia: case report and literature review. Muscle Nerve 37: 125–129

    Article  Google Scholar 

  • Solomon LR (2007) Disorders of cobalamin (vitamin B12) metabolism: emerging concepts in pathophysiology, diagnosis and treatment. Blood Rev 21: 113–130

    Article  CAS  Google Scholar 

  • Troen AM (2005) The central nervous system in animal models of hyperhomocysteinemia. Prog Neuro-Psychopharmacol Biol Psychiat 29 (7):1140–1151

    Article  CAS  Google Scholar 

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Correspondence to A.-S. Biesalski , D. Sturm , A.-S. Biesalski , D. Sturm or A.-S. Biesalski .

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© 2019 Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature

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Biesalski, AS., Sturm, D. (2019). Vitaminmangel-Erkrankungen. In: Sturm, D., Biesalski, AS., Höffken, O. (eds) Neurologische Pathophysiologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-56784-5_5

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  • DOI: https://doi.org/10.1007/978-3-662-56784-5_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-56783-8

  • Online ISBN: 978-3-662-56784-5

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