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Neurodegenerative Erkrankungen

  • Chapter
Neurologische Pathophysiologie

Zusammenfassung

Neurodegenerative Erkrankungen sind progredient verlaufende Krankheiten des Nervensystems. In diesem Kapitel werden die drei Hauptformen neurodegenerativer Erkrankungen – die amyotrophe Lateralsklerose (ALS), die Demenzen sowie Parkinson-Syndrome – dargestellt und hinsichtlich ihrer zugrundeliegenden Pathomechanismen besprochen. Grundlegende Veränderungen, wie das Auftreten abnorm gefalteter und aggregierter Proteine, die sich in Zellen des Nervensystems anreichern und zum Funktionsverlust und schließlich Niedergang unterschiedlicher Zellpopulationen führen, werden besprochen. Zudem werden genetische Grundlagen sowie unterschiedliche Hypothesen zur Ausbreitung der Neurodegeneration behandelt und die wesentlichen beteiligten neuroanatomischen Strukturen aufgezeigt.

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Authors and Affiliations

  1. St.-Josef-Hospital, Klinik für Neurologie, Ruhr-Universität Bochum, Bochum, Deutschland

    Dr. med. A.-S. Biesalski

  2. Klinik für Neurologie, Neurozentrum, Universitätsklinikum Schleswig-Holstein, Kiel, Deutschland

    Dr. med. J. Becktepe & Prof. Dr. med. T. Bartsch

  3. Klinik für Neurologie mit experimenteller Neurologie, Universitätsmedizin Berlin, Berlin, Deutschland

    Dr. med. C. Franke

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  1. Dr. med. A.-S. Biesalski
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Correspondence to A.-S. Biesalski , J. Becktepe , T. Bartsch , C. Franke , A.-S. Biesalski , J. Becktepe , T. Bartsch or C. Franke .

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  1. Agaplesion Bethesda KH Wuppertal, Wuppertal, Deutschland

    Dietrich Sturm

  2. Ruhr-Universität Bochum, Bochum, Deutschland

    Anne-Sophie Biesalski  & Oliver Höffken  & 

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Biesalski, AS., Becktepe, J., Bartsch, T., Franke, C. (2019). Neurodegenerative Erkrankungen. In: Sturm, D., Biesalski, AS., Höffken, O. (eds) Neurologische Pathophysiologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-56784-5_4

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