Zusammenfassung
Epileptische Anfälle sind ein häufiges klinisches Phänomen, und die Lebenszeitprävalenz beträgt bis zu 5%. Die Diagnose einer Epilepsie wird bei dauerhafter Neigung zur Entwicklung epileptischer Anfälle gestellt und zieht die Behandlung mit Antikonvulsiva nach sich. In diesem Kapitel werden die Einteilung in die häufigen Epilepsiesyndrome, die Diagnostik mittels Elektroenzephalographie und Magnetresonanztomographie, die Wirkungsweise von Antikonvulsiva sowie der Status epilepticus vorgestellt. Letzteres ist ein klinischer Notfall, da ab einer Dauer von 5 Minuten die Wahrscheinlichkeit für ein spontanes Sistieren der Anfälle sinkt.
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Literatur
Alldredge BK, Gelb AM, Isaacs SM et al. (2001) A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus. N Engl J Med 345: 631–637
Bancaud J (1969) Physiopathogenesis of generalized epilepsies of organic nature (stereoencephalographic study). In: Gastaut H, Jasper HH, Bancaud J et al. (eds) The Physiopathogenesis of the Epilepsies. Charles C Thomas, Springfield, IL:, pp 158–185
Barrese V, Miceli F, Soldovieri MV et al. (2010) Neuronal potassium channel openers in the management of epilepsy: role and potential of retigabine. Clin Pharmacol 2: 225–236
Bauer S, Norwood BA (2013) What can we learn from animal models of convulsive status epilepticus? Z Epileptol 26: 70–74
Blumenfeld H (2005) Cellular and network mechanisms of spike-wave seizures. Epilepsia 46 Suppl 9: 21–33
Brazel H, Reif PS, Bauer S et al. (2016) Erfolgreiche Epilepsiechirurgie bei seit über 20 Jahren therapierefraktärer Temporallappenepilepsie und multiplen Voreingriffen. Z Epileptol 29: 156–160
Brodie MJ, Barry SJ, Bamagous GA et al. (2012) Patterns of treatment response in newly diagnosed epilepsy. Neurology 78: 1548–1554
Bumanglag AV, Sloviter RS (2008) Minimal latency to hippocampal epileptogenesis and clinical epilepsy after perforant pathway stimulation-induced status epilepticus in awake rats. J Compar Neurol 510: 561–580
Buzsaki G (1991) The thalamic clock: emergent network properties. Neuroscience 41: 351–364
Cain SM, Snutch TP (2012) Voltage-Gated Calcium Channels in Epilepsy. In: Noebels JL, Avoli M, Rogawski MA et al. (eds) Jasper’s Basic Mechanisms of the Epilepsies 4th edition. Bethesda (MD): National Center for Biotechnology Information (US)
Chen JW, Wasterlain CG (2006) Status epilepticus: pathophysiology and management in adults. Lancet Neurol 2006; 5: 246–256
Chen Y, Lu J, Pan H et al. (2003) Association between genetic variation of CACNA1H and childhood absence epilepsy. Ann Neurol 54: 239–243
Conner KP, Woods C, Atkins WM (2011) Interactions of Cytochrome P450s with their Ligands. Arch Biochem Biophys 507: 56–65
Cossette P, Lachance-Touchette P, Rouleau GA (2012) Mutated GABAA receptor subunits in idiopathic generalized epilepsy. In: Noebels JL, Avoli M, Rogawski MA et al. (eds) Jasper’s Basic Mechanisms of the Epilepsies, 4th edn. National Center for Biotechnology Information (US), Bethesda (MD)
Dingledine R (2012) Glutamatergic Mechanisms Related to Epilepsy: Ionotropic Receptors. In: Noebels JL, Avoli M, Rogawski MA et al. (eds) Jasper’s Basic Mechanisms of the Epilepsies, 4th edn. National Center for Biotechnology Information (US), Bethesda (MD)
Duvernoy H, Cattin F, Risold P (2013) The Human Hippocampus. Functional Anatomy, Vascularization and Serial Sections with MRI, 4th edn. Springer, Berlin Heidelberg New York, p 18
French JA, Williamson PD, Thadani VM et al. (1993) Characteristics of medial temporal lobe epilepsy: I. Results of history and physical examination. Ann Neurol 34: 774–780
Gloor P, Avoli M, Kostopoulos G (1990) Thalamocortical relationships in generalized epilepsy with bilaterally synchronous spike-and-wave discharge. In: Avoli M, Gloor P, Kostopoulos G et al. (eds) Generalized epilepsy: neurobiological approaches. Birkhauser, Boston, MA:, pp 190–212
Gloor P (1969) Neurophysiological bases of generalized seizures termed centrencephalic. In: Gastaut H, Jasper HH, Bancaud J et al. (eds) The physiopathogenesis of the epilepsies. Charles C Thomas, Springfield, IL, pp 209–236
Hanada T, Hashizume Y, Tokuhara N et al. (2011) Perampanel: A novel, orally active, noncompetitive AMPA-receptor antagonist that reduces seizure activity in rodent models of epilepsy. Epilepsia 52: 1331–1340
Heron SE, Khosravani H, Varela D et al. (2007) Extended spectrum of idiopathic generalized epilepsies associated with CACNA1H functional variants. Ann Neurol 62: 560–568
Huguenard JR, McCormick DA (2007) Thalamic synchrony and dynamic regulation of global forebrain oscillations. Trends Neurosci 30: 350–356
Jallon P, Latour P (2005) Epidemiology of idiopathic generalized epilepsies. Epilepsia 46 Suppl 9: 10–14
Jasper HH, Droogleever-Fortuyn J (1946) Experimental studies on the functional anatomy of petit mal epilepsy. Res Publ Ass Res Nerv Ment Dis 26: 272–298
Jasper HH, Kershman J (1941) Electroencephalographic classification of the epilepsies. Arch Neurol Psychiat 45: 903–943
Kapur J, Macdonald RL (1997) Rapid seizure-induced reduction of benzodiazepine and Zn2+ sensitivity of hippocampal dentate granule cell GABAA receptors. J Neurosci 17: 7532–7540
Knake S, Rosenow F, Vescovi M et al. (2001) Incidence of status epilepticus in adults in Germany: a prospective, population-based study. Epilepsia 42: 714–718
Kwan P, Arzimanoglou A, Berg AT et al. (2010) Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia 51: 1069–1077
Lorente de Nó R (1934) Studies on the structure of the cerebral cortex. II. Continuation of the study of the Ammonic system. J Psychol Neurol 46: 113–177
Löscher W, Rogawaski MA (1994) Epilepsy. In: Lodge D, Danysz W, Parsons CG, Hrsg. Ionotropic glutamate receptors as therapeutic target. Graham Publ, Johnson City, TN, pp 91–132
Löscher W, Schmidt D (1994) Strategies in antiepileptic drug development: is rational drug design superior to random screening and structural variation? Epilepsy Res 17: 95–134
Löscher W (1989) GABA and the epilepsies. Experimental and clinical considerations. In: Bowery NG, Nisticò G (eds) Basic research and clinical applications. Pythagora Press, Rome, pp 260–300
Lowenstein DH, Alldredge BK (1993) Status epilepticus at an urban public hospital in the 1980s. Neurology 43: 483–488
Lowenstein DH, Bleck T, Macdonald RL (1999) It’s time to revise the definition of status epilepticus. Epilepsia 40: 120–122
Lu Y, Waltz S, Stenzel K et al. (2008) Photosensitivity in epileptic syndromes of childhood and adolescence. Epileptic Disorders: international epilepsy journal with videotape 10: 136–143
Mantegazza M, Catterall WA (2012) Voltage-Gated Na+ Channels: Structure, Function, and Pathophysiology. In: Noebels JL, Avoli M, Rogawski MA et al. (eds) Jasper’s Basic Mechanisms of the Epilepsies. 4th ednNational Center for Biotechnology Information (US), Bethesda (MD)
Meador KJ, Baker GA, Browning N et al. (2009) Cognitive Function at 3 Years of Age after Fetal Exposure to Antiepileptic Drugs. New Engl J Med 360: 1597–1605
Meencke HJ, Janz D (1985) The significance of microdysgenesia in primary generalized epilepsy: an answer to the considerations of Lyon and Gastaut. Epilepsia 26: 368–371
Meeren HK, Pijn JP, Van Luijtelaar EL et al. (2002) Cortical focus drives widespread corticothalamic networks during spontaneous absence seizures in rats. J Neurosci 22: 1480–1495
Meier C, Kraenzlin ME (2011) Epilepsie, Antiepileptika und Osteoporose. Epileptologie 28: 42–50
Morrow J, Russell A, Guthrie E et al. (2006) Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiat 77: 193–198
Noebels JL. (2003) The biology of epilepsy genes. Annu Rev Neurosci 26: 599–625
Penfield W, Jasper HH (1954) Epilepsy and the functional anatomy of the human brain. Little Brown & Co., Boston, MA.
Pitkänen A, Schwartzkroin PA, Moshe SL (2006) Models of seizures and epilepsy. Elsevier, London
Powell KL, Cain SM, Ng C et al. (2009) A Cav3.2 T-type calcium channel point mutation has splice-variant-specific effects on function and segregates with seizure expression in a polygenic rat model of absence epilepsy. J Neurosci 29: 371–380
Reimers A, Brodtkorb E, Sabers A (2015) Interactions between hormonal contraception and antiepileptic drugs: Clinical and mechanistic considerations. Seizure 28: 66–70
Rivera C, Voipio J, Kaila K (2005) Two developmental switches in GABAergic signalling: the K+-Cl- cotransporter KCC2 and carbonic anhydrase CAVII. J Physiol 562: 27–36
Rogawski MA (2011) Revisiting AMPA Receptors as an Antiepileptic Drug Target. Epilepsy Curr 11: 56–63
Rossetti AO, Logroscino G, Milligan TA et al. (2008) Status Epilepticus Severity Score (STESS): a tool to orient early treatment strategy. J Neurol 255: 1561–1566
Scharrer E (1940) Vascularization and vulnerability of the cornu ammonis in the opossum. Arch Neurol Psychiat 44: 483–506
Scheffer IE, Berkovic S, Capovilla G et al. (2017) ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology. Epilepsia 58: 512–521
Schmidt RF, Lang F, Heckmann M (Hrsg) (2010) Physiologie des Menschen, 31. Aufl. Springer, Berlin Heidelberg New York, S 165
Singh B, Monteil A, Bidaud I et al. (2007) Mutational analysis of CACNA1G in idiopathic generalized epilepsy. Mutation in brief #962. Online. Human Mutation 28: 524–525
Strzelczyk A, Ansorge S, Hapfelmeier J et al. (2017) Costs, length of stay, and mortality of super-refractory status epilepticus: A population-based study from Germany. Epilepsia 58: 1533–1541
Strzelczyk A, Gaul C, Rosenow F et al. (2017) Visuelle Auren im Grenzgebiet zwischen Epilepsie und Migräne. Z Epileptol 30: 21–27
Strzelczyk A, Kay L, Kellinghaus C et al. (2017) Concepts for Prehospital and Initial In-hospital Therapy of Status Epilepticus. Neurol Int Open 01: E217-E223
Talley EM, Solorzano G, Depaulis A et al. (2000) Low-voltage-activated calcium channel subunit expression in a genetic model of absence epilepsy in the rat. Brain Res Mol Brain Res 75: 159–165
Trinka E, Cock H, Hesdorffer D et al. (2015) A definition and classification of status epilepticus – Report of the ILAE Task Force on Classification of Status Epilepticus. Epilepsia 56: 1515–1523
Tsakiridou E, Bertollini L, de Curtis M et al. (1995) Selective increase in T-type calcium conductance of reticular thalamic neurons in a rat model of absence epilepsy. J Neurosci 15:3110–3117
Walker MC, Kullmann DM (2012) Tonic GABAA Receptor-Mediated Signaling in Epilepsy. In: Noebels JL, Avoli M, Rogawski MA et al. (eds) Jasper’s Basic Mechanisms of the Epilepsies, 4th edn. National Center for Biotechnology Information (US), Bethesda (MD)
Weber YG, Sander T, Lerche H (2011) Idiopathische generalisierte Epilepsien. Z Epileptol 24: 100–107
Wellmer J, Quesada CM, Rothe L et al. (2013) Proposal for a magnetic resonance imaging protocol for the detection of epileptogenic lesions at early outpatient stages. Epilepsia 54: 1977–1987
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Geithner, J., von Podewils, F., Strzelczyk, A., von Rüden, EL. (2019). Epilepsien. In: Sturm, D., Biesalski, AS., Höffken, O. (eds) Neurologische Pathophysiologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-56784-5_3
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