Zusammenfassung
»Cancer of unknown primary« (CUP) ist charakterisiert als eine Tumorerkrankung mit (zunächst) unbekanntem bzw. vielfach sehr spät detektiertem Primärtumor. Die Heilungschancen stehen in Abhängigkeit von dem Zeitpunkt, zu dem dieser identifiziert und behandelt werden kann sowie von der Anzahl der (resektablen) Metastasen. Erfahrungsgemäß sind in der Gruppe der CUP-Tumoren die Kopf-Hals-Tumoren die größte Tumorentität. Für die Behandlungsplanung und die Abschätzung der Prognose des Patienten ist es erforderlich, nicht nur die gesamte Tumorausdehnung, sondern auch die Herkunft der Metastasen zu ermitteln. Die PET/CT leistet bei der Primärdiagnostik von CUP-Syndromen einen entscheidenden Beitrag.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
Literatur
Assar OS, Fischbein NJ, Caputo GR et al. (1999) Metastatic head and neck cancer: role and usefulness of FDG PET in locating occult primary tumors. Radiology 210: 177–181
Bristow RE, del Carmen MG, Pannu HK et al. (2003) Clinically occult recurrent ovarian cancer: patient selection for secondary cytoreductive surgery using combined PET/CT. Gynecol Oncol 90: 519–528
Burell SC, Van den Abbeele AD (2018) 2-deoxy-2-[F-18]fluoro-Dglucose- positron emission tomography of the head and neck: an atlas of the normal uptake and variants. Mol Imaging Biol 7: 244–256
Czernin J, Auerbach (2018) Clinical PET/CT imaging: promises and misconceptions. Nuklearmedizin 44 (suppl 1): S18–23
Gambhir SS, Czernin J, Schwimmer J et al. (2001) A tabulated summary of the FDG PET literature. J Nucl Med (suppl) 42: 1–93
Greco FA, Hainsworth JD (1993) Cancer of unknown primary site. In: Devita VT Jr, Hellma NS, Rosenberg SA (Hrsg) Cancer: principles and practice of oncology. Lippincott-Raven, Philadelphia, S 2072–2092
Gutzeit A, Antoch G, Kühl H et al. (2018) Unknown primary tumors: detection with dual modality PET/CT-initial experience. Radiology 234: 227–234
Hör G, Mantaka P (1998) Application of PET in clinical oncology. In: Limouris GS, Shukla SK, Bender HF, Biersack HJ (Hrsg) Radionuclides for oncology—current status and future aspects. Mediterra, Athens, S 107–111
Israel O, Mor M, Guralnik L et al. (2004) Is 18F-FDG PET/CT useful for imaging and management of patients with suspected and occult recurrence of cancer? J Nucl Med 45: 2045–2051
Kazmierczak PM, Nikolaou K, Rominger A, Graser A, Reiser MF, Cyran CC (2014) Radiological diagnostics in CUP syndrome. Radiologe 54(2): 117–123
Lee JR, Kim JS, Roh JL, Lee JH, Baek JH, Cho KJ, Choi SH, Nam SY, Kim SY (2015) Detection of Occult Primary Tumors in Patients with Cervical Metastases of Unknown Primary Tumors: Comparison of (18)F FDG PET/CT with Contrast-enhanced CT or CT/MR Imaging-Prospective Study. Radiology 274(3): 764–771
Makaiova I, Vesely J, Kovacova S et al. (2002) False positive uptake of 18FDG-fluorodeoxyglukose in the axillary brown fat lipoma (hibernoma)—case report. EANM, Abstract
Manolidis S, Donald PJ, Volk P, Pounds TR (1998) The use of positron emission tomography scanning in occult and recurrent head and neck cancer. Acta Otolaryngol 534 (suppl): 1–11
Mantaka P, Hertel A, Adams S et al. (1998) Contribution of PETFDG in the diagnosis of cancer of unknown primary. In: Limouris GS, Shukla SK, Bender HF, Biersack HJ (Hrsg) Radionuclides for oncology—current status and future aspects. Mediterra, Athens, S 121–131
Regelink G, Brouwer J, de Bree R et al. (2002) Detection of unknown primary tumours and distant metastases in patients with cervical metastases: value of FDG-PET versus conventional modalities. Eur J Nucl Med 29: 1024–1030
Scott CL, Kudaba I, Stewart JM et al. (2018) The utility of 2-deoxy- 2-[F-18]fluoro-D-glucose positron emission tomography in the investigation of patients with disseminated carcinoma of unknown primary origin. Mol Imaging Biol 7: 236–243
Sengupta MS, Lee SJ, Hoh CK et al. (1995) Utility and cost effectiveness of FDG whole body PET in patients with unknown primary malignancies. J Nucl Med 36: 56
Wahl RL (2004) Why nearly all PET of abdominal and pelvic cancers will be performed as PET/CT. J Nucl Med 45 (suppl 1): S81–95
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Mohnike, W., Hör, G., Lampe, M. (2016). CUP-Tumoren. In: Mohnike, W., Hör, G., Hertel, A., Schelbert, H. (eds) PET/CT-Atlas. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-48842-3_18
Download citation
DOI: https://doi.org/10.1007/978-3-662-48842-3_18
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-48841-6
Online ISBN: 978-3-662-48842-3
eBook Packages: Medicine (German Language)