Abstract
Vascular malformations occur in such an enormous variety of forms and types that they have been a symbol of confusion among various vascular disorders through decades. Unfortunately even until today in many places, the differentiation of hemangiomas and vascular malformations is not precisely known or is not accurately used in daily clinical practice. A fundamental statement was the clear differentiation of vascular tumors and vascular malformations within the topic of vascular anomalies [1]. A concept of rational treatment of these different findings can only be gained on the basis of a classification referring to clear anatomic and pathological features [2].
Access provided by CONRICYT-eBooks. Download chapter PDF
Similar content being viewed by others
Vascular malformations occur in such an enormous variety of forms and types that they have been a symbol of confusion among various vascular disorders through decades. Unfortunately even until today in many places, the differentiation of hemangiomas and vascular malformations is not precisely known or is not accurately used in daily clinical practice. A fundamental statement was the clear differentiation of vascular tumors and vascular malformations within the topic of vascular anomalies [1]. A concept of rational treatment of these different findings can only be gained on the basis of a classification referring to clear anatomic and pathological features [2].
That is why in 1988 following an initiative of Prof. Dr. St. Belov, a consensus conference was performed in Hamburg, Germany (Fig. 9.1) under his leadership and guidance convening international scientists of different specialties. The only topic was to create a classification of congenital vascular malformations, which should be simple, clearly arranged, comprehensible, and implementable in clinical practice. The sessions unanimously resolved that the vascular tumors have to be discussed absolutely apart from the extensive group of the congenital vascular malformations. Following the proposals of Malan [3], those “vascular malformations were differentiated into a number of anatomo-clinical pictures, each with a precise definition of the vascular abnormality, of its evolution and of the therapeutic possibilities.” In addition, Malan introduced the concept of the “predominant type of the involved vessel” because he noticed that in vascular malformations, very rarely only one type of vessel alone is affected, but in most cases polyangiopathies have to be dealt with.
In order to define the vascular malformations which were formed extratruncular out of the primitive vascular network during the reticular stage of its embryonal development, the term extratruncular form was installed into the classification. Within this term the limited form is included as well as the infiltrating form which is specific for vascular malformations. In contrast, the vascular malformations which derive from a disturbance in the late phase of the vessel development affect the main vessels and such are called the truncular forms. Malan [3] and Belov [4, 5] are convinced of the idea that the truncular and the extratruncular forms are the result of a defect in the embryonic phase of development of the vessels. The latest results in molecular and genetic research and development demonstrate that this concept may be right [6].
The Hamburg classification [5] was adopted by this working group in 1988 (Table 9.1), and the conclusion in 1993 [4] was published as follows: “(1) the proposed classification of congenital vascular defects based on anatomic and pathological features has proved to be useful in clinical practice. It is valid for vascular defects in all locations (central, visceral, and peripheral), includes all types and anatomic forms of vascular malformations, yet is quite simplified. (2) A uniform and universal classification system is necessary for clear communication between the many different specialists dealing with congenital vascular defects. (3) It offers a clear and precise descriptive system to serve as the basis for diagnosis of congenital vascular defects. (4) A unified classification system offers the possibility of uniform analysis and comparative reporting between scientific investigators working in this field around the world” (see Table 9.1).
This conclusion, published by Belov [4], became true, and every specialist dedicated to congenital vascular malformations accepted this Hamburg classification and worked with it efficiently. However, soon the capillary/microvascular form was added, and in 2007 a modified Hamburg classification was proposed and worldwide accepted and recommended [7] (Table 9.2).
Further modifications of the Hamburg classification were proposed by the ISSVA (International Society for the Study of Vascular Anomalies) in 1996 and in 2014. While the 1996 modification was elegant in its simplicity, but did not adequately and sufficiently reflect the current understanding of vascular malformations [8], several details were missing. That is why in 2014 another updated and expanded modification was published basing on the original Hamburg classification [9] (Table 9.3). Again capillary (i.e., microvascular), lymphatic, venous and arteriovenous malformations, and arteriovenous fistulas are differentiated. Malformations of the main named vessels are specified again as truncal, and combined extratruncular forms are also considered. In addition, subgroups like “vascular malformations associated with other anomalies” or “provisionally unclassified vascular anomalies” are mentioned. As an appendix the causal genes of vascular anomalies as they are known today are also completely included [10, 11].
Table 9.3 ISSVA classification of 2014
Overview table | |
---|---|
Vascular tumors | Simple vascular malformations (extratruncal) |
Benign v.t. | Capillary m. (CM) |
Locally aggressive or borderline v.t. | Lymphatic m. (LM) primary lymphedema |
Malignant v.t. | Venous m. (VM) |
Arteriovenous m. (AVM) AV fistulas (AVF) | |
Combined vascular malformations (extratruncular) | |
Truncular vascular malformations of major named vessels | |
Lymphatics | |
Veins | |
Arteries |
References
Mulliken JB, Glowacki J. Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. Plast Reconstr Surg. 1982;69:412–22.
Malan E, Puglionisi A. Congenital angiodysplasias of the extremities. Note I: generalities and classification; venous dysplasias. J Cardiovasc Surg (Torino). 1964;5:87–130.
Malan E. Vascular malformations (Angiodysplasias). Milan: Carlo Erba Foundation; 1974.
Belov S. Anatomopathological classification of congenital vascular defects. Semin Vasc Surg. 1993;6(4):219–24.
Belov St. Classification, terminology and nosology of congenital vascular defects. In: Belov St, Loose DA, Weber J, editors. Vascular malformations. Einhorn-Presse Verlag Reinbek; 1989. p. 25–8.
Limaye N, Vikkula M. Molecular and genetic aspects of hemangiomas and vascular malformations. In: Mattassi R, Loose DA, Vaghi M, editors. Hemangiomas and vascular malformations: an atlas of diagnosis and treatment. 2nd ed. Milano: Springer; 2015. p. 21–38.
Lee BB, Bergan J, Gloviczki P, Laredo J, Loose DA, Mattassi R, Parsi K, Villavicencio JL, Zamboni P. Diagnosis and treatment of venous malformations. Consensus document of the International Union of Phlebology (IUP)-2009. Int Angiol. 28(6):434–51.
Enjolras O, Mulliken JB. Vascular tumors and vascular malformations (new issues). Adv Dermatol. 1997;13:375–423.
Michel Wassef, Francine Blei, Denise Adams, Ahmad Alomari, Eulalia Baselga, Alejandro Berenstein, Patricia Burrows, Ilona J. Frieden, Maria C. Garzon, Juan-Carlos Lopez-Gutierrez, David J.E. Lord, Sally Mitchel, Julie Powell, Julie Prendiville, Miikka Vikkula ISSVA Board and Scientific Committee. Vascular anomalies classification: recommendations from the International Society for the Study of Vascular Anomalies. Pediatrics. 2015. doi:10.1542/peds.2014–3673. Originally published online June 8 2015.
Mattassi R, Loose DA. Classification of vascular malformations. In: Mattassi R, Loose DA, Vaghi M, editors. Hemangiomas and vascular malformations. 2nd ed. Italia: Springer; 2015. p. 181–6.
Green AK. Vascular anomalies. Classification, diagnosis and management. Quality Medical Publishing Inc., St.Louis, 2013 9-18
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Loose, D.A., Mattassi, R.E. (2017). Hamburg Classification: Vascular Malformation. In: Kim, YW., Lee, BB., Yakes, W., Do, YS. (eds) Congenital Vascular Malformations. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-46709-1_9
Download citation
DOI: https://doi.org/10.1007/978-3-662-46709-1_9
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-46708-4
Online ISBN: 978-3-662-46709-1
eBook Packages: MedicineMedicine (R0)