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Molekulare Diagnostik bei nahrungsmittelabhängiger anstrengungsinduzierter Anaphylaxie

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Molekulare Allergiediagnostik

Zusammenfassung

Die nahrungsmittelabhängige anstrengungsinduzierte Anaphylaxie (food-dependent exercise-induced anaphylaxis, FDEIA) ist dadurch charakterisiert, dass Nahrungsmittel nur in Kombination mit Augmentationsfaktoren (u. a. körperliche Anstrengung) eine anaphylaktische Reaktion auslösen. Die am besten charakterisierte FDEIA-Entität ist die Weizen-abhängige anstrengungsinduzierte Anaphylaxie (WDEIA), bei der sich spezifische IgE-Antikörper gegen rekombinantes ω-5-Gliadin bei ca. 80 % der Patienten nachweisen lassen. Weitere Allergene bei WDEIA stellen HMW-Glutenin, α/β-Gliadin und γ-Gliadin dar. Eine Vielzahl weiterer Nahrungsmittel (u. a. Meeresfrüchte, Obst, Gemüse, Nüsse und Soja) wurden als Auslöser einer FDEIA beschrieben. Als Majorallergene fungieren in diesen Fällen Lipid-Transfer-Proteine (LTP; beispielsweise das Pfirsich-LTP Pru p 3), Speicherproteine (z. B. das β-Conglycinin Gly m 5 aus Soja) oder im Falle der FDEIA ausgelöst durch Meeresfrüchte das Tropomyosin Pen m 1. Eine Sonderrolle nimmt die meist verzögert auftretende Allergie gegenüber rotem Fleisch ein, die durch spezifische IgE-Antikörper gegen eine Kohlenhydratstruktur (Galaktose -α-1,3-Galaktose) induziert wird.

Der Beitrag basiert auf einer Publikation der Autoren, die 2013 im Allergo Journal erschienen ist (Hofmann SC, Jakob T: Molekulare Diagnostik bei nahrungsmittelabhängiger anstrengungsinduzierter Anaphylaxie. Allergo J 2013; 22: 308–311) und nun als Buchkapitel aktualisiert und erweitert wurde.

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Authors and Affiliations

  1. Universitätsklinikum Gießen u. Marburg, Standort Gießen, Direktor der Klinik für Dermatologie und Allergologie, Gießen, Deutschland

    Univ.-Prof. Dr. med. Thilo Jakob

  2. Zentrum für Dermatologie, Allergologie und Dermatochirurgie, HELIOS Klinikum Wuppertal, Universität Witten/Herdecke, Heusnerstraße 40, 42283, Wuppertal, Deutschland

    PD Dr. med. Silke C. Hofmann

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  1. PD Dr. med. Silke C. Hofmann
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  2. Univ.-Prof. Dr. med. Thilo Jakob
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Editors and Affiliations

  1. Allergie- und Asthma-Zentrum Westend, Praxis Hanf, Ackermann und Kleine-Tebbe, Berlin, Germany

    Jörg Kleine-Tebbe

  2. Universitätsklinikum Gießen und Marburg, Klinik für Dermatologie und Allergologie, Freiburg im Breisgau, Germany

    Thilo Jakob

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Hofmann, S.C., Jakob, T. (2015). Molekulare Diagnostik bei nahrungsmittelabhängiger anstrengungsinduzierter Anaphylaxie. In: Kleine-Tebbe, J., Jakob, T. (eds) Molekulare Allergiediagnostik. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45221-9_15

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  • DOI: https://doi.org/10.1007/978-3-662-45221-9_15

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