Zusammenfassung
Das Virus der lymphozytären Chroriomeningitis (LCMV) ist weltweit verbreitet, infiziert verschiedene Spezies von Wildmäusen und persistiert in diesen. Regional ist die Durchseuchung der Mausspezies unterschiedlich hoch. Die Viren werden im Urin der Tiere ausgeschieden und können auf andere Nagetierspezies (Goldhamster, Renn-/Springmäuse, Chincilla) übertragen werden, wenn diese in der Käfighaltung Kontakt zueinander haben. LCMV kann zoonotisch auf Menschen übertragen werden, die Kontakt mit infizierten Mäusen oder Nagetieren bzw. mit deren Exkrementen (Käfigeinstreu) haben. Die Infektionen verlaufen im Menschen meist ohne oder mit grippeähnlichen Symptomen. Werden Schwangere innerhalb infiziert, so kann die Infektion intrauterin auf deie Feten übertragen werden und eine Embryopathie (Mikroenzephalie) verursachen, die mit Spätfolgen (gesitige Entwicklungsstörungen) verbunden sein kann. Es existiert keine Impfung oder Therapieoption. Eine diagnostische Testung des Infektionsstatus wird nur bei Schwangeren empfohlen, die sehr häufig Kontakt mit potentiell infizierten Nagetieren bzw. deren Exkrementen haben. Die zoonotische Übertragung kann durch entsprechende Hygienemaßnahmen verhindert werden. Akute LCMV-Infektionen bei Schwangeren müssen in Deutschland als Rarität angesehen werden.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
Literatur
Ackermann R, Körver G, Turss R, Wönne R, Hochgesand P (1974) [Prenatal infection with the virus of lymphocytic choriomeningitis: report of two cases (author’s transl)]. Dtsch Med Wochenschr 99(13):629–632
Ackermann R (1977) [Risk to humans through contact with golden hamsters carrying lymphocytic choriomeningitis virus (author’s transl)]. Dtsch Med Wochenschr 102(39):1367–1370
Barton LL, Hyndman NJ (2000) Lymphocytic choriomeningitis virus: reemerging central nervous system pathogen. Pediatrics 2000 Mar;105(3):E35
Barton LL, Mets MB, Beauchamp CL (2002) Lymphocytic choriomeningitis virus: emerging fetal teratogen. Am J Obstet Gynecol 187(6):1715–1716
Barton LL, Mets MB (1999) Lymphocytic choriomeningitis virus: pediatric pathogen and fetal teratogen. Pediatr Infect Dis J 18(6):540–541; PubMed PMID: 10391186
Barton LL, Peters CJ, Ksiazek TG (1995) Lymphocytic choriomeningitis virus: an unrecognized teratogenic pathogen. Emerg Infect Dis 1(4):152–153
Becker SD, Bennett M, Stewart JP, Hurst JL (2003) Serological survey of virus infection among wild house mice (Mus domesticus) in the UK. Lab Anim 2007 Apr;41(2):229–38
Besselsen DG, Wagner AM, Loganbill JK (2003) Detection of lymphocytic choriomeningitis virus by use of fluorogenic nuclease reverse transcriptase-polymerase chain reaction analysis. Comp Med 53(1):65–69
Bonthius DJ, Wright R, Tseng B, Barton L, Marco E et al (2007) Congenital lymphocytic choriomeningitis virus infection: spectrum of disease. Ann Neurol 62(4):347–355
Centers for Disease Control and Prevention – CDC (2005) Lymphocytic choriomeningitis virus infection in organ transplant recipients–Massachusetts, Rhode Island, 2005. MMWR Morb Mortal Wkly Rep 54(21):537–539
Centers for Disease Control and Prevention – CDC (2005) Interim guidance for minimizing risk for human lymphocytic choriomeningitis virus infection associated with rodents. MMWR Morb Mortal Wkly Rep 54(30):747–9
Centers for Disease Control and Prevention – CDC (2006) Survey of lymphocytic choriomeningitis virus diagnosis and testing–Connecticut, 2005. MMWR Morb Mortal Wkly Rep 55(14):398–399
Centers for Disease Control and Prevention – CDC (2005) Update: interim guidance for minimizing risk for human lymphocytic choriomeningitis virus infection associated with pet rodents. MMWR Morb Mortal Wkly Rep 54(32):799–801
Childs JE, Glass GE, Korch GW, Ksiazek TG, Leduc JW (1992) Lymphocytic choriomeningitis virus infection and house mouse (Mus musculus) distribution in urban Baltimore. Am J Trop Med Hyg 47(1):27–34
Childs JE, Glass GE, Ksiazek TG, Rossi CA, Oro JG, Leduc JW (1991) Human-rodent contact and infection with lymphocytic choriomeningitis and Seoul viruses in an inner-city population. Am J Trop Med Hyg 44(2):117–121
Cordey S, Sahli R, Moraz ML, Estrade C, Morandi L et al (2011) Analytical validation of a lymphocytic choriomeningitis virus real-time RT-PCR assay. J Virol Methods 177(1):118–122
Deibel R, Woodall JP, Decher WJ, Schryver GD (1975) Lymphocytic choriomeningitis virus in man. Serologic evidence of association with pet hamsters. JAMA 232(5):501–504
de Lamballerie X, Fulhorst CF, Charrel RN (2007) Prevalence of antibodies to lymphocytic choriomeningitis virus in blood donors in southeastern France. Transfusion 47(1):172–173
Dobec M, Dzelalija B, Punda-Polic V, Zoric I (2006) High prevalence of antibodies to lymphocytic choriomeningitis virus in a murine typhus endemic region in Croatia. J Med Virol 78(12):1643–1647
Enders G, Varho-Göbel M, Löhler J, Terletskaia-Ladwig E, Eggers M (1999) Congenital lymphocytic choriomeningitis virus infection: an underdiagnosed disease. Pediatr Infect Dis J 18(7):652–655
Foster ES, Signs KA, Marks DR, Kapoor H, Casey M et al (2006) Lymphocytic choriomeningitis in Michigan. Emerg Infect Dis 12(5):851–853
Fritz CL, Fulhorst CF, Enge B, Winthrop KL, Glaser CA, Vugia DJ (2002) Exposure to rodents and rodent-borne viruses among persons with elevated occupational risk. J Occup Environ Med 44(10):962–967
Fulhorst CF, Milazzo ML, Armstrong LR, Childs JE, Rollin PE et al (2007) Hantavirus and arenavirus antibodies in persons with occupational rodent exposure. Emerg Infect Dis 13(4):532–538
Greenhow TL, Weintrub PS (2003) Your diagnosis, please. Neonate with hydrocephalus. Pediatr Infect Dis J 22(12):1099, 1111–1112
Hochgesand P, Turss R, Ackermann R (1975) [Prenatal chorio-retinitis transmitted by golden hamsters (author’s transl)]. Klin Monbl Augenheilkd 166(2):190–195
Homberger FR, Romano TP, Seiler P, Hansen GM, Smith AL (1995) Enzyme-linked immunosorbent assay for detection of antibody to lymphocytic choriomeningitis virus in mouse sera, with recombinant nucleoprotein as antigen. Lab Anim Sci 45(5):493–496
Juncker-Voss M, Prosl H, Lussy H, Enzenberg U, Auer H et al (2004) [Screening for antibodies against zoonotic agents among employees of the Zoological Garden of Vienna, Schönbrunn, Austria]. Berl Munch Tierarztl Wochenschr 117(9–10):404–409
Kallio-Kokko H, Laakkonen J, Rizzoli A, Tagliapietra V, Cattadori I et al (2006) Hantavirus and arenavirus antibody prevalence in rodents and humans in Trentino, Northern Italy. Epidemiol Infect 134(4):830–836
Knust B, Macneil A, Wong SJ, Backenson PB, Gibbons A et al (2011) Exposure to lymphocytic choriomeningitis virus, New York, USA. Emerg Infect Dis 17(7):1324–1325
Ledesma J, Fedele CG, Carro F, Lledó L, Sánchez-Seco MP et al (2009) Independent lineage of lymphocytic choriomeningitis virus in wood mice (Apodemus sylvaticus), Spain. Emerg Infect Dis 15(10):1677–1680
Marrie TJ, Saron MF (1998) Seroprevalence of lymphocytic choriomeningitis virus in Nova Scotia. Am J Trop Med Hyg 58(1):47–49
Meritet JF, Krivine A, Lewin F, Poissonnier MH, Poizat R et al (2009) A case of congenital lymphocytic choriomeningitis virus (LCMV) infection revealed by hydrops fetalis. Prenat Diagn 29(6):626–627
McIver CJ, Jacques CF, Chow SS, Munro SC, Scott GM et al (2005) Development of multiplex PCRs for detection of common viral pathogens and agents of congenital infections. J Clin Microbiol 43(10):5102–5110
Mets MB, Barton LL, Khan AS, Ksiazek TG (2000) Lymphocytic choriomeningitis virus: an underdiagnosed cause of congenital chorioretinitis. Am J Ophthalmol 130(2):209–215
Mets MB (1999) Childhood blindness and visual loss: an assessment at two institutions including a "new" cause. Trans Am Ophthalmol Soc 97:653–696
Moll van Charante AW, Groen J, Osterhaus AD (1994) Risk of infections transmitted by arthropods and rodents in forestry workers. Eur J Epidemiol 10(3):349–351
Park JY, Peters CJ, Rollin PE, Ksiazek TG, Katholi CR et al (1997) Age distribution of lymphocytic choriomeningitis virus serum antibody in Birmingham, Alabama: evidence of a decreased risk of infection. Am J Trop Med Hyg 57(1):37–41
Park JY, Peters CJ, Rollin PE, Ksiazek TG, Gray B et al (1997) Development of a reverse transcription-polymerase chain reaction assay for diagnosis of lymphocytic choriomeningitis virus infection and its use in a prospective surveillance study. J Med Virol 51(2):107–114
Parker JC, Igel HJ, Reynolds RK, Lewis AM Jr, Rowe WP (1976) Lymphocytic choriomeningitis virus infection in fetal, newborn, and young adult Syrian hamsters (Mesocricetus auratus). Infect Immun 13(3):967–981
Riera L, Castillo E, Del Carmen Saavedra M, Priotto J, Sottosanti J et al (2005) Serological study of the lymphochoriomeningitis virus (LCMV) in an inner city of Argentina. J Med Virol 76(2):285–289
Sheinbergas MM, Verikene VV, Maslinskas VY, Lyubetsky VB (1978) Sepcific immunofluorescent IgG, IgM, and IgA antibodies in lymphocytic choriomeningitis. Acta Virol 22(3):218–224
Sheinbergas MM (1975) Antibody to lymphocytic choriomeningitis virus in children with congenital hydrocephalus. Acta Virol 19(2):165–166
Sheinbergas MM (1976) Hydrocephalus due to prenatal infection with the lymphocytic choriomeningitis virus. Infection 4(4):185–191
Skinner HH, Knight EH, Buckley LS (1976) The hamster as a secondary reservoir host of lymphocytic choriomeningitis virus. J Hyg (Lond) 76(2):299–306
Stephensen CB, Blount SR, Lanford RE, Holmes KV, Montali RJ et al (1992) Prevalence of serum antibodies against lymphocytic choriomeningitis virus in selected populations from two U.S. cities. J Med Virol 38(1):27–31
Turković B, Ljubicić M (1992) ELISA and indirect immunofluorescence in the diagnosis of LCM virus infections. Acta Virol 36(6):576–580
Vieth S, Drosten C, Lenz O, Vincent M, Omilabu S et al (2007) RT-PCR assay for detection of Lassa virus and related Old World arenaviruses targeting the L gene. Trans R Soc Trop Med Hyg 101(12):1253–1264
Welsh RM, Seedhom MO (2008) Lymphocytic choriomeningitis virus (LCMV): propagation, quantitation, and storage. Curr Protoc Microbiol Chapter 15:Unit 15A.1
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 DVV, GfV
About this chapter
Cite this chapter
Modrow, S. (2014). Lymphozytäre Choriomeningitis. In: S2k-Leitlinie - Labordiagnostik schwangerschaftsrelevanter Virusinfektionen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-43481-9_15
Download citation
DOI: https://doi.org/10.1007/978-3-662-43481-9_15
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-43480-2
Online ISBN: 978-3-662-43481-9
eBook Packages: Medicine (German Language)