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Herpes-simplex-Virusinfektionen

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S2k-Leitlinie - Labordiagnostik schwangerschaftsrelevanter Virusinfektionen

Zusammenfassung

Zusammenfassung Herpes-simplex-Virusinfektionen während der Schwangerschaft können zu schweren neonatalen Infektionen führen. Im Mittelpunkt des vorliegenden Kapitels stehen Empfehlungen für die Labordiagnostik, die im Wesentlichen während sowie nach der Schwangerschaft und/oder beim Neugeborenen von Bedeutung sind.

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Literatur

  1. Anzivino E, Fioriti D, Mischitelli M et al (2009) Herpes simplex virus infection in pregnancy and in neonate: status of art of epidemiology, diagnosis, therapy and prevention. Virol J 6:40

    Article  PubMed Central  PubMed  Google Scholar 

  2. Anonymous (2004) Deutsches Herpes Management Forum. Chemother J 13:27–37

    Google Scholar 

  3. Ashley RL, Dalessio J, Burchett S et al (1992) Herpes simplex virus-2 (HSV-2) type-specific antibody correlates of protection in infants exposed to HSV-2 at birth. J Clin Invest 90:511–514

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  4. Barbi M, Binda S, Primache V et al (1998) Use of Guthrie cards for the early diagnosis of neonatal herpes simplex virus disease. Pediatr Infect Dis J 17:251–252

    Article  CAS  PubMed  Google Scholar 

  5. Bergström T, Trybala E (1996) Antigenic differences between HSV-1 and HSV-2 glycoproteins and their importance for type-specific serology. Intervirology 39:176–184

    PubMed  Google Scholar 

  6. Boucher FD Yasukawa LL, Bronzan RN et al (1990) A prospective evaluation of primary genital herpes simplex virus type 2 infections acquired during pregnancy. Pediatr Infect Dis J 9:499–504

    Article  CAS  PubMed  Google Scholar 

  7. Brown ZA, Selke S, Zeh J et al (1997) The acquisition of herpes simplex during pregnancy. N Engl J Med 337:509–515

    Article  CAS  PubMed  Google Scholar 

  8. Brown ZA, Wald A, Morrow RA, Selke S, Zeh J, Corey L (2003) Effect of serologic status and cesarean section on transmission rates of herpes simplex virus from mother to infant. JAMA 289:203–209

    Article  PubMed  Google Scholar 

  9. Eis-Hübinger AM, Däumer M, Matz B, Schneweis KE (1999) Evaluation of three glycoprotein G2-based enzyme immunoassays for detection of antibodies to herpes simplex virus type 2 in human sera. J Clin Microbiol 37:1242–1246

    PubMed Central  PubMed  Google Scholar 

  10. Eskild A, Jeansson S, Hagen JA, Jenum PA, Skrondal A (2000) Herpes simplex virus type-2 antibodies in pregnant women: the impact of the stage of pregnancy. Epidemiol Infect 125:685–692

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  11. Haddad J, Langer B, Astruc D, Messer J, Lokiec F (1993) Oral acyclovir and recurrent genital herpes during late pregnancy. Obstet Gynecol 82(1):102–104

    CAS  PubMed  Google Scholar 

  12. Ho DW, Field PR, Sjögren-Jansson E, Jeansson S, Cunningham AL (1992) Indirect ELISA for the detection of HSV-2 specific IgG and IgM antibodies with glycoprotein G (gG-2). J Virol Methods 36:249–264

    Article  CAS  PubMed  Google Scholar 

  13. Johansson AB, Rassart A, Blum D, Van Beers D, Liesnard C (2004) Lower-limb hypoplasia due to intrauterine infection with herpes simplex virus type 2: possible confusion with intrauterine varicella-zoster syndrome. Clin Infect Dis 38:e57–62

    Article  PubMed  Google Scholar 

  14. Kimberlin DW, Baley J (2013) Committee on Infectious Diseases and Committee on Fetus and Newborn. Pediatrics e635

    Google Scholar 

  15. Kimberlin DW, Lin CY, Jacobs RF et al (2001) Natural history of neonatal herpes simplex virus infections in the acyclovir era. Pediatrics 108:223–229

    Article  CAS  PubMed  Google Scholar 

  16. Lewensohn-Fuchs I, Österwall P, Forsgren M, Malm G (2003) Detection of herpes simplex virus DNA in dried blood spot making a retrospective diagnosis possible. J Clin Virol 26:39–48

    Article  PubMed  Google Scholar 

  17. Lipsitch M, Davis G, Corey L (2002) Potential benefits of a serodiagnostic test for herpes simplex virus type 1 (HSV-1) to prevent neonatal HSV-1 infection. Sex Transm Dis 29:399–405

    Article  PubMed  Google Scholar 

  18. Major CA, Towers CV, Lewis DF, Garite TJ (2003) Expectant management of preterm premature rupture of mambranes complicated by active recurrent genital herpes. Am J Obstet Gynecol 188:1551–1555

    Article  PubMed  Google Scholar 

  19. Meerbach A, Sauerbrei A, Meerbach W, Bittrich HJ, Wutzler P (2006) Fatal outcome of herpes simplex virus type 1-induced necrotic hepatitis in a neonate. Med Microbiol Immunol 195:101–105

    Article  PubMed  Google Scholar 

  20. Patel R, Alderson S, Geretti A et al (2011) European guideline for the management of genital herpes. Int J STD AIDS 22:1–10

    Article  CAS  PubMed  Google Scholar 

  21. Pasternak B, Hviid A (2010) Use of acyclovir, valacyclovir, and famciclovir in the first trimester of pregnancy and the risk of birth defects. JAMA 304:859–866

    Article  CAS  PubMed  Google Scholar 

  22. Pinninti SG, Kimberlin DW (2013) Maternal and neonatal herpes simplex virus infections. Am J Perinatol 30:113–120

    Article  PubMed  Google Scholar 

  23. Randolph AG, Washington AE, Prober CG (1993) Cesarean delivery for women presenting with genital herpes lesions. Efficacy, risks, and costs JAMA 270:77–82

    Article  CAS  PubMed  Google Scholar 

  24. Sauerbrei A, Eichhorn U, Hottenrott G, Wutzler P (2000) Virological diagnosis of herpes simplex encephalitis. J Clin Virol 17:31–36

    Article  CAS  PubMed  Google Scholar 

  25. Sauerbrei A, Schmitt S, Scheper T et al (2011) Seroprevalence of herpes simplex virus type 1 and type 2 in Thuringia, Germany, 1999 to 2006. Eurosurveillance 16 (44):pii=20005

    Google Scholar 

  26. Sauerbrei A, Wutzler P (2004) Serological detection of type-specific IgG to herpes simplex virus by novel ELISAs based on recombinant and highly purified glycoprotein G. Clin Lab 50:425–429

    CAS  PubMed  Google Scholar 

  27. Sauerbrei A, Wutzler P (2007) Herpes simplex and varicella-zoster virus infections during pregnancy – current concepts of prevention, diagnosis and therapy Part 1: Herpes simplex virus infections. Med Microbiol Immunol 196:89–94

    Article  CAS  PubMed  Google Scholar 

  28. Scott LL, Hollier LM, McIntire D et al (2001) Acyclovir suppression to prevent clinical recurrences at delivery after first episode genital herpes in pregnancy: an open-label trial. Infect Dis Obstet Gynecol 9:75–80

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  29. Scott LL, Hollier LM, McIntire D et al (2002) Acyclovir suppression to prevent recurrent genital herpes at delivery. Infect Dis Obstet Gynecol 10:71–77

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  30. Stone KM, Reiff-Eldridge R, White AD et al (2004) Pregnancy outcomes following systemic prenatal acyclovir exposure: conclusions from the international acyclovir pregnancy registry, 1984–1999. Birth Defects Res Clin Mol Teratol 70:201–207

    Article  CAS  Google Scholar 

  31. Swiss herpes management forum (2004) Swiss recommendations for the management of genital herpes and herpes simplex virus infection in the neonate. Swiss Med Wkly 134:205–214

    Google Scholar 

  32. Whitley R, Arvin A, Prober C et al (1991) A controlled trial comparing vidarabine with acyclovir in neonatal herpes simplex virus infection. N Engl J Med 324:444–449

    Article  CAS  PubMed  Google Scholar 

  33. Wutzler P, Doerr HW, Färber I et al (2000) Seroprevalence of herpes simplex virus type 1 and type 2 in selected German populations – Relevance for the incidence of genital herpes. J Med Virol 61:201–207

    Article  CAS  PubMed  Google Scholar 

  34. Záhumenskỳ J, Vlácil J, Holub M et al (2010) Antiviral prophylaxis of neonatal infection. Prague Med Rep 111:142–147

    PubMed  Google Scholar 

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  1. Institut für Virologie und Antivirale Therapie, Universitätsklinikum Jena, Hans-Knöll-Str. 2, 07745, Jena, Deutschland

    Andreas Sauerbrei

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    Sauerbrei, A. (2014). Herpes-simplex-Virusinfektionen. In: S2k-Leitlinie - Labordiagnostik schwangerschaftsrelevanter Virusinfektionen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-43481-9_14

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    • DOI: https://doi.org/10.1007/978-3-662-43481-9_14

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    • Publisher Name: Springer, Berlin, Heidelberg

    • Print ISBN: 978-3-662-43480-2

    • Online ISBN: 978-3-662-43481-9

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