Zusammenfassung
Die Osteoporose ist laut WHO-Definition eine systemische Skeletterkrankung, die charakterisiert ist durch eine niedrige Knochenmasse und eine Störung der Mikroarchitektur des Knochengewebes mit konsekutiv erhöhter Knochenbrüchigkeit und erhöhtem Frakturrisiko. Sie wird zusätzlich operational auf Basis der Messung der Knochendichte durch den T-Score definiert. Die Leitlinie des Dachverbands Osteologie integriert in die Definition der Osteoporose klinische Aspekte und berücksichtigt insbesondere neben der Diagnose einer niedrigen Knochendichte die klinischen Risikofaktoren sowie den Einfluss medikamentöser Therapien auf das Frakturrisiko. Eine Ursache für die steigende Inzidenz der Osteoporose ist u. a. die tumor- bzw. therapieinduzierte Osteoporose, die in diesem Buchkapitel am Beispiel des Mammakarzinoms, welches die häufigste maligne Erkrankung der Frau ist, dargestellt wird.
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Kalder, M., Hadji, P. (2014). Pathophysiologie und Behandlung der therapieinduzierten Osteoporose. In: Stenzl, A., Fehm, T., Hofbauer, L., Jakob, F. (eds) Knochenmetastasen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-43471-0_12
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