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The Role of Opiate Withdrawal in Addiction

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Neurobiological Mechanisms of Opiate Withdrawal

Part of the book series: Neuroscience Intelligence Unit ((NIU.LANDES))

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Abstract

The role of withdrawal in drug addiction has diminished in recent years as much research has shown the powerful effects of opiates to produce positive reinforcement. A major impetus for this conceptual framework was the observation that animals and humans could take opiates under limited access situations without any evidence of physical dependence.1 This view of a more limited role of withdrawal in addiction is reflected in the change of withdrawal being only one of seven criteria for a definition of addiction in DSM-IV2 rather than being an essential criteria for addiction.3

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Author information

Authors and Affiliations

  1. Pharmacochimie Moléculaire et Structurale, Paris, France

    Rafael Maldonado M.D., Ph.D.

  2. Université de Bordeaux II, Bordeaux Cédex, France

    Luis Stinus Ph.D.

  3. The Scripps Research Institute, La Jolla, California, USA

    George F. Koob Ph.D.

Authors
  1. Rafael Maldonado M.D., Ph.D.
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  2. Luis Stinus Ph.D.
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  3. George F. Koob Ph.D.
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© 1996 Springer-Verlag Berlin Heidelberg

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Maldonado, R., Stinus, L., Koob, G.F. (1996). The Role of Opiate Withdrawal in Addiction. In: Neurobiological Mechanisms of Opiate Withdrawal. Neuroscience Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22218-8_8

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  • DOI: https://doi.org/10.1007/978-3-662-22218-8_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-22220-1

  • Online ISBN: 978-3-662-22218-8

  • eBook Packages: Springer Book Archive

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