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Structural Determinants of Receptor Function

  • Chapter
G Protein-Coupled Receptors

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

Investigation of structure-function relationships in G protein-coupled receptors has been directed towards identification of residues and do mains of the receptors which are of significance in ligand binding, functional activation, G protein coupling and desensitization of receptor activity. Much attention has been focused on rhodopsin, and the adrenergic and muscarinic acetylcholine receptor subtypes, since these were among the first members of the receptor superfamily to be isolated. Determination of structural determinants of function in these receptors has provided a valuable framework for delineation of structure-function relationships in other members of the receptor superfamily. It is becoming increasingly apparent that structural determinants of function are contributed by sequence features which are discontinuous within the primary protein sequence and which arise from the three-dimensional structure of the receptor protein and the molecular species with which it interacts, namely its extracellular ligand(s) and intracellular G proteins.

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Authors
  1. Tiina P. Iismaa Ph.D.
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  2. Trevor J. Biden Ph.D.
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  3. John Shine Ph.D.
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© 1995 Springer-Verlag Berlin Heidelberg

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Iismaa, T.P., Biden, T.J., Shine, J. (1995). Structural Determinants of Receptor Function. In: G Protein-Coupled Receptors. Molecular Biology Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-21930-0_3

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  • DOI: https://doi.org/10.1007/978-3-662-21930-0_3

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