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Signaling Through G Protein-Coupled Receptors

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G Protein-Coupled Receptors

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

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Abstract

Gprotein-coupled receptors are now defined in molecular terms and rightly so. Their most salient characteristic is the possession of a number of structural motifs the most important of which is the hydrophobicity profile diagnostic of seven membrane-spanning domains. Accordingly some investigators have advanced the terms serpentine or heptahelical as alternative, and more structurally descriptive, names for this class of receptor. These have not caught on and probably won’t. Although undoubtedly clumsy, the term G protein-coupled receptor is of both historical and functional significance. It encapsulates what is still the most relevant characteristic of this class of receptor: its ability to couple to G proteins.

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Authors
  1. Tiina P. Iismaa Ph.D.
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Iismaa, T.P., Biden, T.J., Shine, J. (1995). Signaling Through G Protein-Coupled Receptors. In: G Protein-Coupled Receptors. Molecular Biology Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-21930-0_2

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  • DOI: https://doi.org/10.1007/978-3-662-21930-0_2

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