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Molecularly Imprinted Polymers as Recognition Elements in Sensors

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Ultrathin Electrochemical Chemo- and Biosensors

Part of the book series: Springer Series on Chemical Sensors and Biosensors ((SSSENSORS,volume 2))

Abstract

The technique of molecular imprinting allows for the formation of specific recognition sites in synthetic polymers through the use of templates or imprint molecules. These recognition sites mimic the binding sites of biological receptor molecules such as antibodies and enzymes. Molecularly imprinted polymers can therefore be used in applications based on specific molecular binding events, such as affinity separation, assays and sensors, and in organic synthesis and catalysis. The stability, ease of preparation, and low cost of these materials make them particularly attractive. This review focuses on recent developments and advances in the molecular imprinting technique with special emphasis on applications in sensors.

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Abbreviations

MIP:

Molecularly imprinted polymer

SAW:

Surface acoustic wave

QCM:

Quartz crystal microbalance

2,4-D:

2,4-Dichlorophenoxyacetic acid

FTIR:

Fourier-transform infrared

References

  1. Sellergren B (2001) Molecularly imprinted polymers - Man-made mimics of antibodies and their applications in analytical chemistry. Elsevier, Amsterdam

    Google Scholar 

  2. Mosbach K, Ramström O (1996) Biotechnology (NY) 14: 163

    Article  CAS  Google Scholar 

  3. Wulff G (1995) Angew Chem Int Ed 34: 1812

    Article  CAS  Google Scholar 

  4. Klein JU, Whitcombe MJ, Mulholland F, Vulfson EN (1999) Angew Chem Int Ed 38: 2057

    Article  CAS  Google Scholar 

  5. Yilmaz E, Mosbach K, Haupt K (1999) Anal Commun 36: 167

    Article  CAS  Google Scholar 

  6. Steinke JHG, Dunkin IR, Sherrington DC (1999) Trends Anal Chem 18: 159

    Article  CAS  Google Scholar 

  7. Spivak D, Shea KJ (1999) J Org Chem 64: 4627

    Article  CAS  Google Scholar 

  8. Wulff G, Gross T, Schönfeld R (1997) Angew Chem Int Ed 36: 1962

    Article  CAS  Google Scholar 

  9. Yano K, Tanabe K, Takeuchi T, Matsui J, Ikebukuro K, Karube I (1998) Anal Chim Acta 363: 111

    Article  CAS  Google Scholar 

  10. Lübke C, Lübke M, Whitcombe MJ, Vulfson EN (2000) Macromolecules 33: 5098

    Article  Google Scholar 

  11. Mallik S, Johnson RD, Arnold FH (1994) J Am Chem Soc 116: 8902

    Article  CAS  Google Scholar 

  12. Hart BR, Shea KJ (2001) J Am Chem Soc 123: 2072

    Article  CAS  Google Scholar 

  13. Kempe M, Glad M, Mosbach K (1995) J Mol Recognit 8: 35

    Article  CAS  Google Scholar 

  14. Takeuchi T, Fukuma D, Matsui J (1999) Anal Chem 71: 285

    Article  CAS  Google Scholar 

  15. Lanza F, Sellergren B (1999) Anal Chem 71: 2092

    Article  CAS  Google Scholar 

  16. Panasyuk TL, Mirsky VM, Piletsky SA, Wolfbeis OS (1999) Anal Chem 71: 4609

    Article  CAS  Google Scholar 

  17. Piletsky SA, Piletska EV, Chen B, Karim K, Weston D, Barrett G, Lowe P, Turner APF (2000) Anal Chem 72: 4381

    Article  CAS  Google Scholar 

  18. Malitesta C, Losito I, Zambonin PG (1999) Anal Chem 71: 1366

    Article  CAS  Google Scholar 

  19. Peng H, Liang C, Zhou A, Zhang Y, Xie Q,Yao S (2000) Anal Chim Acta 423: 221–228

    Article  CAS  Google Scholar 

  20. Dickert FL, Tortschanoff M, Bulst WE, Fischerauer G (1999) Anal Chem 71: 4559

    Article  CAS  Google Scholar 

  21. Deore B, Chen Z, Nagaoka T (2000) Anal Chem 72: 3989

    Article  CAS  Google Scholar 

  22. Dai S, Shin Y, Barnes CE, Toth LM (1997) Chem Mater 9: 2521

    Article  CAS  Google Scholar 

  23. Glad M, Norrlöw O, Sellergren B, Siegbahn N, Mosbach K (1985) J Chromatogr 347: 11

    Article  CAS  Google Scholar 

  24. Makote R, Collinson MM (1998) Chem Commun 3: 425

    Article  Google Scholar 

  25. Sasaki DY, Rush DJ, Daitch CE, Alam TM, Assink RA, Ashley CS, Brinker CJ, Shea KJ (1998) ACS Symp Ser 703: 314

    Article  CAS  Google Scholar 

  26. Markowitz MA, Kust PR, Deng G, Schoen PE, Dordick JS, Clark DS, Gaber BP (2000) Langmuir 16: 1759

    Article  CAS  Google Scholar 

  27. Sasaki DY, Alam TM (2000) Chem Mater 12: 1400

    Article  CAS  Google Scholar 

  28. Katz A, Davis ME (2000) Nature 403: 286

    Article  CAS  Google Scholar 

  29. Lulka MF, Chambers JP, Valdes ER, Thompson RG, Valdes JJ (1997) Anal Lett 30: 2301

    Article  CAS  Google Scholar 

  30. Lulka MF, Iqbal SS, Chambers JP, Valdes ER, Thompson RG, Goode MT, Valdes JJ (2000) Mat Sci Eng C-Bio S 11: 101–105

    Article  Google Scholar 

  31. Igbal SS, Lulka MF, Chambers JP, Thompson RG, Valdes JJ (2000) Mat Sci Eng C-Bio S 7: 77–81

    Article  Google Scholar 

  32. Lahav M, Kharitonov AB, Katz O, Kunitake T, Willner I (2001) Anal Chem 73: 720

    Article  CAS  Google Scholar 

  33. Lee SW, Ichinose I, Kunitake T (1998) Langmuir 14: 2857

    Article  CAS  Google Scholar 

  34. Lee SW, Ichinose I, Kunitake T (1998) Chem Lett 12: 1193

    Article  Google Scholar 

  35. Kato M, Nishide H, Tsuchida E, Sasaki T (1981) J Polym Sci Polym Chem 19: 1803

    CAS  Google Scholar 

  36. Kido H, Miyama T, Tsukagoshi K, Maeda M, Takagi M (1992) Anal Sci 8: 749

    Article  CAS  Google Scholar 

  37. Chen H, Olmstead MM, Albright RL, Devenyi J, Fish RH (1997) Angew Chem Int Ed 36: 642

    Article  CAS  Google Scholar 

  38. Aherne A, Alexander C, Payne MJ, Perez N, Vulfson EN (1996) J Am Chem Soc 118: 8771

    Article  CAS  Google Scholar 

  39. D’Souza SM, Alexander C, Carr SW, Waller AM, Whitcombe MJ, Vulfson EN (1999) Nature 398: 312

    Article  Google Scholar 

  40. Shi HQ, Tsai WB, Garrison MD, Ferrari S, Ratner BD (1999) Nature 398: 593

    Article  CAS  Google Scholar 

  41. Ye L, Weiss R, Mosbach K (2000) Macromolecules 33: 8239

    Article  CAS  Google Scholar 

  42. Ye L, Cormack PAG, Mosbach K (1999) Anal Commun 36: 35

    Article  CAS  Google Scholar 

  43. Surugiu I, Ye L, Yilmaz E, Dzgoev A, Danielsson B, Mosbach K, Haupt K (2000) Analyst 125: 13

    Article  CAS  Google Scholar 

  44. Biffis A, Graham NB, Siedlaczek G, Stalberg S, Wulff G (2001) Macromol Chem Phys 202: 163–171

    Article  CAS  Google Scholar 

  45. Ishii T, Nakashima K, Shinkai S (1998) Chem Commun 9: 1047

    Article  Google Scholar 

  46. Zimmerman SC, Wendland MS, Rakow NA, Zharov I, Suslick KS (2002) Nature 418: 399

    Article  CAS  Google Scholar 

  47. Pérez N, Whitcombe MJ, Vulfson EN (2001) Macromolecules 34: 830

    Article  Google Scholar 

  48. Yilmaz E, Haupt K, Mosbach K (2000) Angew Chem Int Ed 39: 2115

    Article  CAS  Google Scholar 

  49. Piletsky SA, Matuschewski H, Schedler U, Wilpert A, Piletska EV, Thiele TA, Ulbricht M (2000) Macromolecules 33: 3092

    Article  CAS  Google Scholar 

  50. Sulitzky C, Ruckert B, Hall AJ, Lanza F, Unger K, Sellergren B (2002) Macromolecules 35: 79

    Article  CAS  Google Scholar 

  51. Panasyuk-Delaney T, Mirsky VM, Ulbricht M, Wolfbeis OS (2001) Anal Chim Acta 435: 157

    Article  CAS  Google Scholar 

  52. Xia Y, Whitesides GM (1998) Angew Chem Int Ed 37: 550

    Article  CAS  Google Scholar 

  53. Yan M, Kapua A (2000) Polymer Prepr 41: 264–265

    CAS  Google Scholar 

  54. Haupt K (2001) Analyst 126: 747–756

    Article  CAS  Google Scholar 

  55. Andersson L, Mandenius CF, Mosbach K (1988) Tetrahedron Lett 29: 5437

    Article  CAS  Google Scholar 

  56. Andersson LI, Miyabayashi A, O’Shannessy DJ, Mosbach K (1990) J Chromatogr 516: 323

    Article  CAS  Google Scholar 

  57. Piletsky SA, Parhometz YP, Lavryk NV, Panasyuk TL, El’skaya AV (1994) Sens Actuators B Chem 18–19: 629

    Article  Google Scholar 

  58. Hedborg E, Winquist F, Lundström I, Andersson LI, Mosbach K (1993) Sens Actuators A Phys 36–38: 796

    Article  Google Scholar 

  59. Benes E, Groschl M, Burger W, Schmidt M (1995) Sens Actuators A Phys 48: 1

    Article  Google Scholar 

  60. Tom-Moy M, Baer RL, Spira-Solomon D, Doherty TP (1995) Anal Chem 67: 1510

    Google Scholar 

  61. Dickert FL, Hayden O, Halikias KP (2001) Analyst 126: 766–771

    Article  CAS  Google Scholar 

  62. Haupt K, Noworyta K, Kutner W (1999) Anal Commun 36: 391

    Article  CAS  Google Scholar 

  63. Liang C, Peng H, Bao X, Nie L,Yao S (1999) Analyst 124: 1781

    Article  CAS  Google Scholar 

  64. Dickert FL, Forth P, Lieberzeit P, Tortschanoff M (1998) Fresenius J Anal Chem 360: 759

    Article  CAS  Google Scholar 

  65. Ji H-S, McNiven S, Ikebukuro K, Karube I (1999) Anal Chim Acta 390: 93

    Article  CAS  Google Scholar 

  66. Dickert FL, Hayden 0 (2002) Anal Chem 74: 1302

    Article  CAS  Google Scholar 

  67. Kugimiya A, Takeuchi T (1999) Electroanal 11: 1158

    Article  CAS  Google Scholar 

  68. Panasyuk-Delaney T, Mirsky VM, Wolfbeis OS (2002) Electroanal 14: 221

    Article  CAS  Google Scholar 

  69. Sergeyeva TA, Piletsky SA, Brovko AA, Slinchenko EA, Sergeeva LM, Panasyuk TL, Elskaya AV (1999) Analyst 124: 331

    Article  CAS  Google Scholar 

  70. Weber A, Dettling M, Brunner H, Tovar GEM (2002) Macromol Rapid Commun 23: 824

    Article  CAS  Google Scholar 

  71. Xie B, Ramanathan K, Danielsson B (1999) Adv Biochem Eng Biotechnol 64: 1

    CAS  Google Scholar 

  72. Kriz D, Ramström O, Svensson A, Mosbach K (1995) Anal Chem 67: 2142

    Article  CAS  Google Scholar 

  73. Andersson LI, Paprica A, Arvidsson T (1997) Chromatographia 46: 57

    Article  CAS  Google Scholar 

  74. Levi R, McNiven S, Piletsky SA, Cheong SH, Yano K, Karube I (1997) Anal Chem 69: 2017

    Article  CAS  Google Scholar 

  75. Haupt K, Mayes AG, Mosbach K (1998) Anal Chem 70: 3936

    Article  CAS  Google Scholar 

  76. Haupt K (1999) React Funct Polym 41: 125

    Article  CAS  Google Scholar 

  77. Piletsky SA, Terpetschnik E, Andersson HS, Nicholls IA, Wollbeis OS (1999) Fresenius J Anal Chem 364: 512

    Article  CAS  Google Scholar 

  78. Kriz D, Mosbach K (1995) Anal Chim Acta 300: 71

    Article  CAS  Google Scholar 

  79. Kröger S, Turner APF, Mosbach K, Haupt K (1999) Anal Chem 71: 3698

    Article  Google Scholar 

  80. Turkewitsch P, Wandelt B, Darling GD, Powell WS (1998) Anal Chem 70: 2025

    Article  CAS  Google Scholar 

  81. Liao Y, Wang W, Wang B (1999) Bioorg Chem 27: 463

    Article  CAS  Google Scholar 

  82. Matsui J, Higashi M, Takeuchi T (2000) J Am Chem Soc 122: 5218

    Article  CAS  Google Scholar 

  83. Jenkins AL, Uy OM, Murray GM (1999) Anal Chem 71: 373

    Article  CAS  Google Scholar 

  84. Jakusch M, Janotta M, Mizaikoff B, Mosbach K, Haupt K (1999) Anal Chem 71: 4786

    Article  CAS  Google Scholar 

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Haupt, K. (2004). Molecularly Imprinted Polymers as Recognition Elements in Sensors. In: Mirsky, V.M. (eds) Ultrathin Electrochemical Chemo- and Biosensors. Springer Series on Chemical Sensors and Biosensors, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05204-4_2

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  • DOI: https://doi.org/10.1007/978-3-662-05204-4_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-05961-2

  • Online ISBN: 978-3-662-05204-4

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