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BCG Vaccination in the Control of Tuberculosis

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Tuberculosis

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 215))

Abstract

The history of the bacillus of Calmette and Guérin (BCG) begins in 1908 when Calmette and Guérin began their work with Lait Nocard, a virulent bovine strain of Mycobacterium tuberculosis isolated by Nocard from a cow that had tuberculous mastitis. Calmette and Guérin subcultured the organism every 3 weeks on a glycerinated beef-bile-potato medium. In 1921, after 13 years and 230 subcultures, BCG had lost its virulence for animals (Grange et al. 1983; Gardner 1932; Crispen 1989). The first child immunized with BCG in July 1921 was a newborn whose grandmother had tuberculosis. Since then more than 1 billion children in more than 182 countries throughout the world have been vaccinated with BCG.

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Authors and Affiliations

  1. Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, 1600 Clifton Road, Mailstop E10, Atlanta, 30333, USA

    R. E. Huebner

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  1. Department of Health and Human Services, Immunology and Molecular Pathogenesis Section, Division of AIDS, STD and TB Laboratory Research, Centers for Disease Control and Prevention, 30333, Atlanta, GA, USA

    Thomas M. Shinnick Ph.D. (Chief) (Chief)

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Huebner, R.E. (1996). BCG Vaccination in the Control of Tuberculosis. In: Shinnick, T.M. (eds) Tuberculosis. Current Topics in Microbiology and Immunology, vol 215. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80166-2_12

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  • DOI: https://doi.org/10.1007/978-3-642-80166-2_12

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