Abstract
G-protein-coupled receptors (GPCRs) are a diverse family of integral membrane proteins that are believed to share many structural and functional properties. Upon stimulation, these receptors can transmit a signal across the bilayer that results in the activation of enzymes or transport systems via a G-protein. The size of the family is increasing rapidly and includes the neurotransmitter receptors (e.g., adrenergic, muscarinic acetylcholine, neurokinins, dopamine, serotonin) as well as the visual and odorant receptors (e.g., rhodopsin).
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Findlay, J.B.C., Donnelly, D. (1993). The Superfamily: Molecular Modelling. In: Dickey, B.F., Birnbaumer, L. (eds) GTPases in Biology II. Handbook of Experimental Pharmacology, vol 108 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78345-6_2
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DOI: https://doi.org/10.1007/978-3-642-78345-6_2
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