Abstract
A variety of agonists interact with surface receptors on their target cells to stimulate inositol phospholipid-specific phospholipase C (PLC; Rana and Hokin 1990; Majerus 1992). Activated PLC catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate two second messenger molecules, diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol is the physiological activator of protein kinase C (PKC) and IP3 induces the release of Ca2+ from internal stores (Rana and Hokin 1990).
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Park, D. (1993). Phospholipase C-β Isozymes Activated by Gαq Members. In: Dickey, B.F., Birnbaumer, L. (eds) GTPases in Biology II. Handbook of Experimental Pharmacology, vol 108 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78345-6_15
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DOI: https://doi.org/10.1007/978-3-642-78345-6_15
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