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High-Voltage Activated Ca2+ Channel

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GTPases in Biology II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 108 / 2))

Abstract

Calcium channels are part of the signal system which is vital for intercellular communication in higher multicellular organisms. They transduce electrical or hormonal signals into a chemical second messenger, namely calcium. The cytosolic calcium concentration controls numerous cellular functions by binding to distinct calcium receptor binding proteins such as calmodulin, troponin, or calcium-activated potassium channels. Voltage-dependent calcium channels are of particular interest since their opening or closing determinates the cellular calcium concentration of many cells. In the normal heart they are essential to the generation of normal cardiac rhythm, to impulse propagation through the atrioventricular node, and to contraction in atrial and ventricular muscle. In vascular smooth muscle calcium channels provide part of the calcium that controls smooth muscle contraction and vascular tone. In skeletal muscle they are an essential part of the tubular excitation-contraction coupling mechanism. In neuronal and neuroendocrine cells they are essential for neurotransmitter release (for recent reviews see Bertolino and Llinas 1992; Brown and Birnbaumer 1990; Miller 1992; Rios et al. 1992; Trautwein and Hescheler 1990).

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Authors
  1. F. Hofmann
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  2. M. Biel
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  3. E. Bosse
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  4. R. Hullin
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  5. P. Ruth
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  6. A. Welling
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  7. V. Flockerzi
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Editors and Affiliations

  1. Baylor College of Medicine, Department of Medicine Cell Biology and Experimental Therapeutics, Houston VA Medical Center, Room 3C-385, 2002 Holcombe Boulevard, Houston, TX, 77030, USA

    Burton F. Dickey M.D.

  2. Department of Cell Biology, Molecular Physiology and Biophysics, Medicine and Neurosciences, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA

    Lutz Birnbaumer Ph.D.

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© 1993 Springer-Verlag Berlin Heidelberg

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Hofmann, F. et al. (1993). High-Voltage Activated Ca2+ Channel. In: Dickey, B.F., Birnbaumer, L. (eds) GTPases in Biology II. Handbook of Experimental Pharmacology, vol 108 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78345-6_14

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  • DOI: https://doi.org/10.1007/978-3-642-78345-6_14

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