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Molecular Diversity of Mammalian Adenylyl Cyclases: Functional Consequences

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GTPases in Biology II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 108 / 2))

Abstract

Adenylyl cyclase (EC 4.6.1.1) converts MgATP into 3′,5′-cyclic AMP (cAMP) and pyrophosphate. Since the initial characterization of the enzyme by Sutherland and coworkers in 1962 adenylyl cyclase activities have been identified in organisms ranging from bacteria to man. The structure and regulation of these adenylyl cyclase enzymes as well as the regulatory role of the cAMP produced varies considerably across this evolutionary distance.

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  1. R. T. Premont
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  2. J. Chen
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  3. O. Jacobowitz
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  4. R. Iyengar
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Editors and Affiliations

  1. Baylor College of Medicine, Department of Medicine Cell Biology and Experimental Therapeutics, Houston VA Medical Center, Room 3C-385, 2002 Holcombe Boulevard, Houston, TX, 77030, USA

    Burton F. Dickey M.D.

  2. Department of Cell Biology, Molecular Physiology and Biophysics, Medicine and Neurosciences, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA

    Lutz Birnbaumer Ph.D.

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© 1993 Springer-Verlag Berlin Heidelberg

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Premont, R.T., Chen, J., Jacobowitz, O., Iyengar, R. (1993). Molecular Diversity of Mammalian Adenylyl Cyclases: Functional Consequences. In: Dickey, B.F., Birnbaumer, L. (eds) GTPases in Biology II. Handbook of Experimental Pharmacology, vol 108 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78345-6_12

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  • DOI: https://doi.org/10.1007/978-3-642-78345-6_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78347-0

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