Abstract
Many cell-surface receptors control the activity of their effector, signal-generating, systems through specific members of a family of guanine nucleotide-binding regulatory proteins (G-proteins) (Birnbaumer et al. 1988; Spiegel 1990). These are heterotrimeric species consisting of α, β and γ subunits. It is the α subunits which are used to define the particular G-protein, and these are responsible for interaction with both the receptor and signal generator as well as binding and hydrolysing GTP. Upon the interaction of an occupied receptor with an appropriate G-protein, it binds GTP, dissociates, and the GTP-bound α-subunit subsequently interacts with the effector system. The “turn-off” reaction is effected by the hydrolysis of GTP to GDP and the reassociation of the G-protein complex.
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Houslay, M.D. (1993). Phosphorylation of Heterotrimeric G-Protein. In: Dickey, B.F., Birnbaumer, L. (eds) GTPases in Biology II. Handbook of Experimental Pharmacology, vol 108 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78345-6_10
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DOI: https://doi.org/10.1007/978-3-642-78345-6_10
Publisher Name: Springer, Berlin, Heidelberg
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