Abstract
The CD44 transmembrane glycoprotein of 90 kDa has been known for more than 10 years under such diverse designations as lymphocyte homing receptor (gp90Hermes), phagocytic glycoprotein (Pgp-1), extracellular matrix receptor III (ECMRIII) and hyaluronate receptor (H-CAM) (see reviews by Haynes et al. 1989 and 1991). Studies with monoclonal antibodies revealed similarity, and most likely identity, among these molecules (Omary etal. 1988; Gallatin et al. 1989; Picker et al. 1989; Aruffo et al. 1990; Miyake et al. 1990; Culty et al. 1990). When the human, baboon and murine cDNA sequences were established identity was confirmed. However, the cDNA sequence codes only for about 360 amino acids, revealing a 37 kDa protein core (Stamenkovic et al. 1989; Goldstein et al. 1989; Idzerda et al. 1989; Nottenburg et al. 1989; Zhou et al. 1989; Wolffe et al. 1990). This protein core is highly glycosylated by N- and O-linked sugars to yield a 85–90 kDa form and is sometimes additionally linked to chondroitin sulfate side chains to produce a 180–220 kDa form (Jalkanen et al. 1988; Stamenkovic et al. 1989).
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© 1993 Springer-Verlag Berlin · Heidelberg
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Günthert, U. (1993). CD44: A Multitude of Isoforms with Diverse Functions. In: Dunon, D., Mackay, C.R., Imhof, B.A. (eds) Adhesion in Leukocyte Homing and Differentiation. Current Topics in Microbiology and Immunology, vol 184. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78253-4_4
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DOI: https://doi.org/10.1007/978-3-642-78253-4_4
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