Abstract
Positron emission tomography (PET) and suitable radioligands have been used to determine D2 dopamine receptor occupancy in the basal ganglia of patients undergoing neuroleptic drug treatment. The dopamine hypothesis of antipsychotic drug action has been supported by consistent PET findings of a high D2 dopamine receptor occupancy in patients treated with conventional clinical doses of chemically distinct classes of antipsychotic drugs (Farde et al. 1988; Smith et al. 1988; Baron et al. 1989).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Andén NE, Stock G (1973) Effect of clozapine on the turnover of dopamine in the corpus striatum and the limbic system. J Pharm Pharmacol 25: 346
Baron JC, Martinot JL, Cambon H, Boulenger JP, Poirier MF, Caillard V, Blin J, Huret JD, Loc’h C, Maziére B (1989) Striatal dopamine receptor occupancy during and following withdrawal from neuroleptic treatment: correlative evaluation by positron emission tomography and plasma prolactine levels. Psychopharmacology (Berl) 99: 463–472
Barnes TRE (1989) A rating scale for drug-induced akathisia. Br J Psychiatry 154: 672–676
Bergström M, Boethius J, Eriksson L, Greitz T, Ribbe T, Widen L (1981) Head fixation device for reproducible positron alignment in transmission CT and positron emission tomography. J Comput Assist Tomogr 8: 74–87
Bing R (1923) Über einige bemerkenswerte Begleiterscheinigungen der extrapyramidalen Rigidität (Akathesie - Mocrographie - Kinesia paradoxica). Schweiz Med Wochenschr 53: 167–171
Cortés R, Camps M, Gueye B, et al. (1989) Dopamine receptors in human brain: autoradiographic distribution of D1 and D2 sites in Parkinson syndrome of different etiology. Brain Res 483: 30–38
ECDEU (1976) Assessment manual for psychopharmacology. US Department of Health, Education and Welfare, Washington
Farde L, Ehrin E, Eriksson L, Greitz T, Hall H, Hedström C-G, Litton J-E, Sedvall G (1985) Substituted benzamides as ligands for visualization of dopamine-D2 receptor binding in the living human brain by poistron emission tomography. Proc Natl Acad Sci USA 82: 3863–3867
Farde L, Hall H, Ehrin E, Sedvall G (1986) Quantitative analysis of dopamine-D2 receptor binding in the living human brain by positron emission tomography. Science 231: 258–261
Farde L, Wiesel F-A, Halldin C, Sedvall G (1988) Central D2-dopamine receptor occupancy in schizophrenic patients treated with antipsychotic drugs. Arch Gen Psychiatry 45: 71–78
Farde L, Wiesel F-A, Halldin C, Stone-Elander S, Nordström A-L, Hall H, Sedvall G (1990) D2-dopamine receptor characteristics in neuroleptic-naive patients with schizophrenia - a PET-study with [llCJraclopride. Arch Gen Psychiatry 47: 213–219
Farde L, Nordström A-L, Wiesel F-A, Pauli S, Halldin C, Sedvall G (1992) PET-analysis of central Dl- and D2-dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine - relation to extrapyramidal side effects. Arch Gen Psychiatry 49: 538–544
Halldin C, Farde L, Högberg T, Hall H, Stöm P, Ohlberger A, Solin O (1991) A comparative PET-study of five carbon-11 or fluorine-18 labelled salicylamides: preparation and in vitro dopamine D2 receptor binding. Nucl Med Biol 8: 871–881
Litton J, Bergström L, Eriksson L, Bohm C, Blomqvist G, Kesselberg M (1984) Performance study of the PC-384 positron camera system for emission tomography of the brain. J Comput Assist Tomogr 8: 74–87
Ryan F, Joiner L, Ryan A Jr (1985) The minitab handbook, 2nd edn. Duxbury Boston, pp 185–190
Shapiro SS, Wilk MB (1972) An analysis of variance test for normality (complete samples). Biometrika 52: 591
Simpson GM, Angus JWS (1970) A rating scale for extrapyramidal side effects. Acta Psychiatr Scand 45 Suppl 212: 11–19
Smith M, Wolf AP, Brodie JD, Arnett CD, Barouche F, Shiue CY, Fowler JS, Russell JAG, MacGregor RR, Wolkin A, Angrist B, Rotrosen J, Peselow E (1988) Serial [18F]N-methylspiperone PET studies to measure changes in antipsychotic drug D-2 receptor occupancy in schizophrenic patients. Biol Psychiatry 23: 653–663
Sokoloff P, Giros B, Martres MP, Bouthenet ML, Schwartz JC (1990) Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics. Nature 347: 146–151
Van Tol H, Bunzow J, Guan H, Sunahara R, Seeman P, Niznik H, Civelli O (1991) Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine. Nature 350: 610–614
Wilson SA, Kinnier JW (1940) Encephalitis. In: Bruce AN (ed) Neurology, vols 1 and 2. A William Wood book. Williams and Wilkins, Baltimore, pp 118, (vol 1), 793 (vol 2 )
Wong DF, Gjedde A, Wagner HN Jr (1986) Quantification of neuroreceptors in the living human brain. I. Irreversible binding of ligands. J Cereb Blood Flow Metab 6: 137–146
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Farde, L., Nordström, AL. (1993). PET Examination of Central D2 Dopamine Receptor Occupancy in Relation to Extrapyramidal Syndromes in Patients Being Treated with Neuroleptic Drugs. In: Gram, L.F., Balant, L.P., Meltzer, H.Y., Dahl, S.G. (eds) Clinical Pharmacology in Psychiatry. Psychopharmacology Series, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78010-3_9
Download citation
DOI: https://doi.org/10.1007/978-3-642-78010-3_9
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-78012-7
Online ISBN: 978-3-642-78010-3
eBook Packages: Springer Book Archive